| Full name: coagulation factor II, thrombin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 2147 | HGNC ID: HGNC:3535 | Ensembl Gene: ENSG00000180210 | OMIM ID: 176930 |
| Drug and gene relationship at DGIdb | |||
F2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of F2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | F2 | 2147 | 205754_at | -0.0044 | 0.9908 | |
| GSE20347 | F2 | 2147 | 205754_at | -0.0258 | 0.7531 | |
| GSE23400 | F2 | 2147 | 205754_at | -0.1245 | 0.0004 | |
| GSE26886 | F2 | 2147 | 205754_at | 0.3573 | 0.0268 | |
| GSE29001 | F2 | 2147 | 205754_at | -0.1539 | 0.3003 | |
| GSE38129 | F2 | 2147 | 205754_at | -0.0743 | 0.3146 | |
| GSE45670 | F2 | 2147 | 205754_at | 0.2039 | 0.0285 | |
| GSE53622 | F2 | 2147 | 44442 | 0.1536 | 0.0983 | |
| GSE53624 | F2 | 2147 | 44442 | 0.1819 | 0.0060 | |
| GSE63941 | F2 | 2147 | 205754_at | 0.2727 | 0.1238 | |
| GSE77861 | F2 | 2147 | 205754_at | -0.1326 | 0.3625 | |
| GSE97050 | F2 | 2147 | A_23_P94879 | -0.0327 | 0.8874 | |
| TCGA | F2 | 2147 | RNAseq | -2.9848 | 0.0547 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by F2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of F2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | F2 | 2147 | 3 | 7 | 20 | |
| GSE20123 | F2 | 2147 | 3 | 6 | 21 | |
| GSE43470 | F2 | 2147 | 2 | 4 | 37 | |
| GSE46452 | F2 | 2147 | 8 | 5 | 46 | |
| GSE47630 | F2 | 2147 | 3 | 9 | 28 | |
| GSE54993 | F2 | 2147 | 3 | 0 | 67 | |
| GSE54994 | F2 | 2147 | 1 | 10 | 42 | |
| GSE60625 | F2 | 2147 | 0 | 0 | 11 | |
| GSE74703 | F2 | 2147 | 2 | 2 | 32 | |
| GSE74704 | F2 | 2147 | 2 | 4 | 14 | |
| TCGA | F2 | 2147 | 12 | 19 | 65 |
Total number of gains: 39; Total number of losses: 66; Total Number of normals: 383.
Somatic mutations of F2:
Generating mutation plots.
Highly correlated genes for F2:
Showing top 20/911 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| F2 | FAM171A2 | 0.833918 | 3 | 0 | 3 |
| F2 | MAGEA8 | 0.79395 | 3 | 0 | 3 |
| F2 | ACSM5 | 0.7516 | 4 | 0 | 4 |
| F2 | IL17RE | 0.747414 | 3 | 0 | 3 |
| F2 | ADAMTS2 | 0.747032 | 3 | 0 | 3 |
| F2 | CPNE9 | 0.744464 | 3 | 0 | 3 |
| F2 | C4BPA | 0.738703 | 3 | 0 | 3 |
| F2 | CALCA | 0.738218 | 4 | 0 | 4 |
| F2 | AICDA | 0.73662 | 3 | 0 | 3 |
| F2 | LCN8 | 0.730545 | 3 | 0 | 3 |
| F2 | ADAM21 | 0.726903 | 3 | 0 | 3 |
| F2 | ISLR2 | 0.725924 | 3 | 0 | 3 |
| F2 | GPD1 | 0.725278 | 4 | 0 | 4 |
| F2 | SPATA2L | 0.724542 | 3 | 0 | 3 |
| F2 | IGFN1 | 0.723957 | 3 | 0 | 3 |
| F2 | P2RY4 | 0.720769 | 4 | 0 | 4 |
| F2 | TREH | 0.709463 | 3 | 0 | 3 |
| F2 | CDH4 | 0.709204 | 5 | 0 | 5 |
| F2 | AIRE | 0.708753 | 6 | 0 | 6 |
| F2 | FOXB1 | 0.707837 | 6 | 0 | 5 |
For details and further investigation, click here
