| Full name: autoimmune regulator | Alias Symbol: PGA1|APS1 | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 326 | HGNC ID: HGNC:360 | Ensembl Gene: ENSG00000160224 | OMIM ID: 607358 |
| Drug and gene relationship at DGIdb | |||
Expression of AIRE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AIRE | 326 | 208090_s_at | 0.0088 | 0.9801 | |
| GSE20347 | AIRE | 326 | 208090_s_at | -0.0966 | 0.2602 | |
| GSE23400 | AIRE | 326 | 208090_s_at | -0.1547 | 0.0000 | |
| GSE26886 | AIRE | 326 | 208090_s_at | 0.3234 | 0.0157 | |
| GSE29001 | AIRE | 326 | 208090_s_at | -0.1358 | 0.3295 | |
| GSE38129 | AIRE | 326 | 208090_s_at | -0.1210 | 0.0816 | |
| GSE45670 | AIRE | 326 | 208090_s_at | -0.1062 | 0.1846 | |
| GSE53622 | AIRE | 326 | 10979 | -0.0499 | 0.4005 | |
| GSE53624 | AIRE | 326 | 10979 | -0.1917 | 0.0030 | |
| GSE63941 | AIRE | 326 | 208090_s_at | -0.0866 | 0.5643 | |
| GSE77861 | AIRE | 326 | 208090_s_at | -0.1448 | 0.2225 | |
| GSE97050 | AIRE | 326 | A_23_P68740 | -0.0952 | 0.6450 | |
| SRP133303 | AIRE | 326 | RNAseq | -0.6147 | 0.0053 | |
| SRP193095 | AIRE | 326 | RNAseq | -0.4338 | 0.0384 | |
| TCGA | AIRE | 326 | RNAseq | -0.4292 | 0.6722 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AIRE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AIRE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AIRE | 326 | 2 | 8 | 20 | |
| GSE20123 | AIRE | 326 | 2 | 8 | 20 | |
| GSE43470 | AIRE | 326 | 0 | 13 | 30 | |
| GSE46452 | AIRE | 326 | 1 | 21 | 37 | |
| GSE47630 | AIRE | 326 | 6 | 17 | 17 | |
| GSE54993 | AIRE | 326 | 8 | 1 | 61 | |
| GSE54994 | AIRE | 326 | 4 | 8 | 41 | |
| GSE60625 | AIRE | 326 | 0 | 0 | 11 | |
| GSE74703 | AIRE | 326 | 0 | 10 | 26 | |
| GSE74704 | AIRE | 326 | 1 | 4 | 15 | |
| TCGA | AIRE | 326 | 8 | 39 | 49 |
Total number of gains: 32; Total number of losses: 129; Total Number of normals: 327.
Somatic mutations of AIRE:
Generating mutation plots.
Highly correlated genes for AIRE:
Showing top 20/1018 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AIRE | TTLL9 | 0.827351 | 3 | 0 | 3 |
| AIRE | ARHGAP30 | 0.79324 | 3 | 0 | 3 |
| AIRE | SLC16A11 | 0.775575 | 3 | 0 | 3 |
| AIRE | HDAC10 | 0.775375 | 3 | 0 | 3 |
| AIRE | ASPHD1 | 0.763273 | 3 | 0 | 3 |
| AIRE | WDR38 | 0.751822 | 3 | 0 | 3 |
| AIRE | MAGEA8 | 0.747735 | 3 | 0 | 3 |
| AIRE | KHDC3L | 0.744349 | 3 | 0 | 3 |
| AIRE | PRAMEF12 | 0.74053 | 5 | 0 | 5 |
| AIRE | CDH23 | 0.73937 | 3 | 0 | 3 |
| AIRE | PTPRCAP | 0.739292 | 3 | 0 | 3 |
| AIRE | SEZ6L2 | 0.739265 | 3 | 0 | 3 |
| AIRE | CLEC12B | 0.726965 | 3 | 0 | 3 |
| AIRE | ZDHHC8 | 0.725238 | 3 | 0 | 3 |
| AIRE | JSRP1 | 0.724211 | 4 | 0 | 3 |
| AIRE | AKR7A3 | 0.710305 | 4 | 0 | 4 |
| AIRE | PTGDR2 | 0.710062 | 4 | 0 | 3 |
| AIRE | SCARF2 | 0.709388 | 3 | 0 | 3 |
| AIRE | SEMA3B | 0.709208 | 6 | 0 | 5 |
| AIRE | F2 | 0.708753 | 6 | 0 | 6 |
For details and further investigation, click here
