| Full name: FAT atypical cadherin 2 | Alias Symbol: MEGF1|CDHF8|HFAT2|CDHR9 | ||
| Type: protein-coding gene | Cytoband: 5q33.1 | ||
| Entrez ID: 2196 | HGNC ID: HGNC:3596 | Ensembl Gene: ENSG00000086570 | OMIM ID: 604269 |
| Drug and gene relationship at DGIdb | |||
Expression of FAT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FAT2 | 2196 | 208153_s_at | 0.6294 | 0.3990 | |
| GSE20347 | FAT2 | 2196 | 208153_s_at | -0.1479 | 0.5738 | |
| GSE23400 | FAT2 | 2196 | 208153_s_at | 0.1348 | 0.3945 | |
| GSE26886 | FAT2 | 2196 | 208153_s_at | -0.1424 | 0.7766 | |
| GSE29001 | FAT2 | 2196 | 208153_s_at | 0.0603 | 0.8767 | |
| GSE38129 | FAT2 | 2196 | 208153_s_at | 0.5310 | 0.1893 | |
| GSE45670 | FAT2 | 2196 | 208153_s_at | 0.4931 | 0.0346 | |
| GSE53622 | FAT2 | 2196 | 9995 | 0.4901 | 0.0820 | |
| GSE53624 | FAT2 | 2196 | 9995 | 0.0442 | 0.8064 | |
| GSE63941 | FAT2 | 2196 | 208153_s_at | 2.8595 | 0.0661 | |
| GSE77861 | FAT2 | 2196 | 208153_s_at | -0.0101 | 0.9881 | |
| GSE97050 | FAT2 | 2196 | A_23_P81507 | 0.5925 | 0.2694 | |
| SRP007169 | FAT2 | 2196 | RNAseq | 0.1823 | 0.7927 | |
| SRP008496 | FAT2 | 2196 | RNAseq | 0.2496 | 0.5241 | |
| SRP064894 | FAT2 | 2196 | RNAseq | -0.2633 | 0.5089 | |
| SRP133303 | FAT2 | 2196 | RNAseq | 0.6009 | 0.1707 | |
| SRP159526 | FAT2 | 2196 | RNAseq | -0.1237 | 0.8369 | |
| SRP193095 | FAT2 | 2196 | RNAseq | 0.1983 | 0.6973 | |
| TCGA | FAT2 | 2196 | RNAseq | 1.3342 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by FAT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FAT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FAT2 | 2196 | 1 | 12 | 17 | |
| GSE20123 | FAT2 | 2196 | 1 | 12 | 17 | |
| GSE43470 | FAT2 | 2196 | 2 | 11 | 30 | |
| GSE46452 | FAT2 | 2196 | 0 | 27 | 32 | |
| GSE47630 | FAT2 | 2196 | 0 | 20 | 20 | |
| GSE54993 | FAT2 | 2196 | 9 | 1 | 60 | |
| GSE54994 | FAT2 | 2196 | 2 | 16 | 35 | |
| GSE60625 | FAT2 | 2196 | 0 | 0 | 11 | |
| GSE74703 | FAT2 | 2196 | 2 | 8 | 26 | |
| GSE74704 | FAT2 | 2196 | 1 | 7 | 12 | |
| TCGA | FAT2 | 2196 | 6 | 40 | 50 |
Total number of gains: 24; Total number of losses: 154; Total Number of normals: 310.
Somatic mutations of FAT2:
Generating mutation plots.
Highly correlated genes for FAT2:
Showing top 20/321 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FAT2 | RAPGEFL1 | 0.740918 | 4 | 0 | 4 |
| FAT2 | ALPK1 | 0.706828 | 3 | 0 | 3 |
| FAT2 | B3GNT5 | 0.689869 | 3 | 0 | 3 |
| FAT2 | CLDN7 | 0.687285 | 3 | 0 | 3 |
| FAT2 | CSTA | 0.676695 | 3 | 0 | 3 |
| FAT2 | KLF5 | 0.675348 | 4 | 0 | 4 |
| FAT2 | HES2 | 0.670487 | 6 | 0 | 6 |
| FAT2 | STAP2 | 0.665165 | 4 | 0 | 3 |
| FAT2 | CDK5R1 | 0.657995 | 5 | 0 | 5 |
| FAT2 | TMPRSS4 | 0.641764 | 4 | 0 | 4 |
| FAT2 | NEDD8 | 0.637336 | 3 | 0 | 3 |
| FAT2 | FAM83B | 0.636919 | 6 | 0 | 4 |
| FAT2 | MTMR1 | 0.636082 | 4 | 0 | 3 |
| FAT2 | TSEN54 | 0.633267 | 3 | 0 | 3 |
| FAT2 | ETFB | 0.632303 | 3 | 0 | 3 |
| FAT2 | MIR205HG | 0.626302 | 5 | 0 | 4 |
| FAT2 | SERPINB13 | 0.625982 | 4 | 0 | 4 |
| FAT2 | PIGW | 0.62586 | 3 | 0 | 3 |
| FAT2 | FERMT1 | 0.625326 | 7 | 0 | 5 |
| FAT2 | SLC37A2 | 0.625012 | 5 | 0 | 4 |
For details and further investigation, click here
