| Full name: Rap guanine nucleotide exchange factor like 1 | Alias Symbol: Link-GEFII | ||
| Type: protein-coding gene | Cytoband: 17q21.1 | ||
| Entrez ID: 51195 | HGNC ID: HGNC:17428 | Ensembl Gene: ENSG00000108352 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of RAPGEFL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAPGEFL1 | 51195 | 218657_at | -0.3505 | 0.5940 | |
| GSE20347 | RAPGEFL1 | 51195 | 218657_at | -1.2300 | 0.0002 | |
| GSE23400 | RAPGEFL1 | 51195 | 218657_at | -1.0874 | 0.0000 | |
| GSE26886 | RAPGEFL1 | 51195 | 218657_at | -1.6834 | 0.0001 | |
| GSE29001 | RAPGEFL1 | 51195 | 218657_at | -1.1454 | 0.0027 | |
| GSE38129 | RAPGEFL1 | 51195 | 218657_at | -0.5963 | 0.2470 | |
| GSE45670 | RAPGEFL1 | 51195 | 218657_at | -0.4582 | 0.0835 | |
| GSE53622 | RAPGEFL1 | 51195 | 115234 | -1.2087 | 0.0000 | |
| GSE53624 | RAPGEFL1 | 51195 | 115234 | -1.5638 | 0.0000 | |
| GSE63941 | RAPGEFL1 | 51195 | 218657_at | 1.3433 | 0.0692 | |
| GSE77861 | RAPGEFL1 | 51195 | 218657_at | -0.3678 | 0.4562 | |
| GSE97050 | RAPGEFL1 | 51195 | A_23_P152970 | -0.2025 | 0.6260 | |
| SRP007169 | RAPGEFL1 | 51195 | RNAseq | -1.5332 | 0.0012 | |
| SRP008496 | RAPGEFL1 | 51195 | RNAseq | -1.8665 | 0.0000 | |
| SRP064894 | RAPGEFL1 | 51195 | RNAseq | -1.7777 | 0.0000 | |
| SRP133303 | RAPGEFL1 | 51195 | RNAseq | -1.7041 | 0.0000 | |
| SRP159526 | RAPGEFL1 | 51195 | RNAseq | -1.3354 | 0.0430 | |
| SRP193095 | RAPGEFL1 | 51195 | RNAseq | -1.5564 | 0.0000 | |
| SRP219564 | RAPGEFL1 | 51195 | RNAseq | -1.8359 | 0.0565 | |
| TCGA | RAPGEFL1 | 51195 | RNAseq | 0.3113 | 0.0294 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by RAPGEFL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAPGEFL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAPGEFL1 | 51195 | 8 | 1 | 21 | |
| GSE20123 | RAPGEFL1 | 51195 | 8 | 1 | 21 | |
| GSE43470 | RAPGEFL1 | 51195 | 1 | 2 | 40 | |
| GSE46452 | RAPGEFL1 | 51195 | 34 | 0 | 25 | |
| GSE47630 | RAPGEFL1 | 51195 | 8 | 1 | 31 | |
| GSE54993 | RAPGEFL1 | 51195 | 3 | 4 | 63 | |
| GSE54994 | RAPGEFL1 | 51195 | 8 | 5 | 40 | |
| GSE60625 | RAPGEFL1 | 51195 | 4 | 0 | 7 | |
| GSE74703 | RAPGEFL1 | 51195 | 1 | 1 | 34 | |
| GSE74704 | RAPGEFL1 | 51195 | 5 | 1 | 14 | |
| TCGA | RAPGEFL1 | 51195 | 22 | 8 | 66 |
Total number of gains: 102; Total number of losses: 24; Total Number of normals: 362.
Somatic mutations of RAPGEFL1:
Generating mutation plots.
Highly correlated genes for RAPGEFL1:
Showing top 20/1196 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAPGEFL1 | GRHL1 | 0.759428 | 7 | 0 | 7 |
| RAPGEFL1 | SH2D3A | 0.752435 | 4 | 0 | 4 |
| RAPGEFL1 | CYP2C9 | 0.747244 | 10 | 0 | 10 |
| RAPGEFL1 | CKMT1A | 0.745508 | 3 | 0 | 3 |
| RAPGEFL1 | SLC9A3R1 | 0.743422 | 13 | 0 | 12 |
| RAPGEFL1 | EVPL | 0.742583 | 13 | 0 | 13 |
| RAPGEFL1 | ZDHHC13 | 0.74097 | 11 | 0 | 11 |
| RAPGEFL1 | FAT2 | 0.740918 | 4 | 0 | 4 |
| RAPGEFL1 | ARHGAP32 | 0.735582 | 11 | 0 | 11 |
| RAPGEFL1 | EPS8L2 | 0.734376 | 10 | 0 | 10 |
| RAPGEFL1 | UPK3B | 0.732934 | 3 | 0 | 3 |
| RAPGEFL1 | ZDHHC5 | 0.731135 | 6 | 0 | 6 |
| RAPGEFL1 | ARAP2 | 0.730754 | 3 | 0 | 3 |
| RAPGEFL1 | DGKA | 0.728162 | 12 | 0 | 11 |
| RAPGEFL1 | PITX1 | 0.727562 | 12 | 0 | 12 |
| RAPGEFL1 | RARG | 0.725596 | 12 | 0 | 12 |
| RAPGEFL1 | PRRG4 | 0.72441 | 11 | 0 | 11 |
| RAPGEFL1 | CYP2C18 | 0.724272 | 10 | 0 | 10 |
| RAPGEFL1 | SPRR2B | 0.723268 | 3 | 0 | 3 |
| RAPGEFL1 | FAM135A | 0.721729 | 8 | 0 | 7 |
For details and further investigation, click here
