| Full name: alpha kinase 1 | Alias Symbol: Lak|FLJ22670|KIAA1527 | ||
| Type: protein-coding gene | Cytoband: 4q25 | ||
| Entrez ID: 80216 | HGNC ID: HGNC:20917 | Ensembl Gene: ENSG00000073331 | OMIM ID: 607347 |
| Drug and gene relationship at DGIdb | |||
Expression of ALPK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALPK1 | 80216 | 227438_at | 0.2714 | 0.3110 | |
| GSE20347 | ALPK1 | 80216 | 207133_x_at | 0.1876 | 0.3581 | |
| GSE23400 | ALPK1 | 80216 | 207133_x_at | -0.0855 | 0.0934 | |
| GSE26886 | ALPK1 | 80216 | 227438_at | -0.0627 | 0.8472 | |
| GSE29001 | ALPK1 | 80216 | 207133_x_at | 0.0801 | 0.6976 | |
| GSE38129 | ALPK1 | 80216 | 207133_x_at | -0.0011 | 0.9956 | |
| GSE45670 | ALPK1 | 80216 | 227438_at | 0.2032 | 0.1273 | |
| GSE53622 | ALPK1 | 80216 | 141144 | -0.1943 | 0.0154 | |
| GSE53624 | ALPK1 | 80216 | 141144 | 0.0305 | 0.7130 | |
| GSE63941 | ALPK1 | 80216 | 227438_at | -0.0524 | 0.9331 | |
| GSE77861 | ALPK1 | 80216 | 227438_at | -0.1800 | 0.3415 | |
| GSE97050 | ALPK1 | 80216 | A_23_P144531 | 0.1781 | 0.4199 | |
| SRP007169 | ALPK1 | 80216 | RNAseq | 0.0137 | 0.9709 | |
| SRP008496 | ALPK1 | 80216 | RNAseq | 0.1039 | 0.7051 | |
| SRP064894 | ALPK1 | 80216 | RNAseq | 0.2695 | 0.0894 | |
| SRP133303 | ALPK1 | 80216 | RNAseq | 0.2113 | 0.1736 | |
| SRP159526 | ALPK1 | 80216 | RNAseq | -0.4168 | 0.1172 | |
| SRP193095 | ALPK1 | 80216 | RNAseq | 0.0857 | 0.4109 | |
| SRP219564 | ALPK1 | 80216 | RNAseq | 0.0784 | 0.7851 | |
| TCGA | ALPK1 | 80216 | RNAseq | -0.1228 | 0.0725 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ALPK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALPK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALPK1 | 80216 | 1 | 13 | 16 | |
| GSE20123 | ALPK1 | 80216 | 1 | 13 | 16 | |
| GSE43470 | ALPK1 | 80216 | 0 | 14 | 29 | |
| GSE46452 | ALPK1 | 80216 | 1 | 36 | 22 | |
| GSE47630 | ALPK1 | 80216 | 0 | 20 | 20 | |
| GSE54993 | ALPK1 | 80216 | 9 | 0 | 61 | |
| GSE54994 | ALPK1 | 80216 | 1 | 10 | 42 | |
| GSE60625 | ALPK1 | 80216 | 0 | 3 | 8 | |
| GSE74703 | ALPK1 | 80216 | 0 | 12 | 24 | |
| GSE74704 | ALPK1 | 80216 | 0 | 7 | 13 | |
| TCGA | ALPK1 | 80216 | 8 | 35 | 53 |
Total number of gains: 21; Total number of losses: 163; Total Number of normals: 304.
Somatic mutations of ALPK1:
Generating mutation plots.
Highly correlated genes for ALPK1:
Showing top 20/185 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALPK1 | SIGLEC15 | 0.720037 | 5 | 0 | 5 |
| ALPK1 | PRKAR2A | 0.717505 | 4 | 0 | 4 |
| ALPK1 | FAT2 | 0.706828 | 3 | 0 | 3 |
| ALPK1 | SFTPB | 0.700832 | 4 | 0 | 3 |
| ALPK1 | MAP2K7 | 0.698961 | 5 | 0 | 3 |
| ALPK1 | ZC3H7B | 0.695279 | 5 | 0 | 3 |
| ALPK1 | HDAC1 | 0.694205 | 3 | 0 | 3 |
| ALPK1 | ST14 | 0.674515 | 3 | 0 | 3 |
| ALPK1 | TMCO6 | 0.672291 | 4 | 0 | 3 |
| ALPK1 | DIP2A | 0.670956 | 7 | 0 | 5 |
| ALPK1 | ANP32A-IT1 | 0.666567 | 3 | 0 | 3 |
| ALPK1 | KLHL28 | 0.661873 | 5 | 0 | 4 |
| ALPK1 | PDP1 | 0.661317 | 3 | 0 | 3 |
| ALPK1 | BIN3-IT1 | 0.650024 | 3 | 0 | 3 |
| ALPK1 | AP1S3 | 0.649549 | 3 | 0 | 3 |
| ALPK1 | SFI1 | 0.648945 | 5 | 0 | 4 |
| ALPK1 | TCERG1 | 0.640479 | 3 | 0 | 3 |
| ALPK1 | DCLRE1C | 0.636164 | 7 | 0 | 5 |
| ALPK1 | PKP2 | 0.635032 | 3 | 0 | 3 |
| ALPK1 | SIGLEC6 | 0.63472 | 4 | 0 | 4 |
For details and further investigation, click here
