| Full name: cyclin dependent kinase 5 regulatory subunit 1 | Alias Symbol: p35nck5a|Nck5a|p35 | ||
| Type: protein-coding gene | Cytoband: 17q11.2 | ||
| Entrez ID: 8851 | HGNC ID: HGNC:1775 | Ensembl Gene: ENSG00000176749 | OMIM ID: 603460 |
| Drug and gene relationship at DGIdb | |||
CDK5R1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05010 | Alzheimer's disease | |
| hsa05030 | Cocaine addiction |
Expression of CDK5R1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDK5R1 | 8851 | 204995_at | 0.2474 | 0.8816 | |
| GSE20347 | CDK5R1 | 8851 | 204995_at | -0.5972 | 0.0615 | |
| GSE23400 | CDK5R1 | 8851 | 204996_s_at | -0.1334 | 0.0006 | |
| GSE26886 | CDK5R1 | 8851 | 204995_at | -0.8989 | 0.0197 | |
| GSE29001 | CDK5R1 | 8851 | 204995_at | -0.5523 | 0.1983 | |
| GSE38129 | CDK5R1 | 8851 | 204995_at | -0.0632 | 0.8855 | |
| GSE45670 | CDK5R1 | 8851 | 204995_at | 0.4037 | 0.0535 | |
| GSE53622 | CDK5R1 | 8851 | 60370 | -0.0736 | 0.7691 | |
| GSE53624 | CDK5R1 | 8851 | 60370 | -0.2341 | 0.0376 | |
| GSE63941 | CDK5R1 | 8851 | 204995_at | 0.6246 | 0.4012 | |
| GSE77861 | CDK5R1 | 8851 | 204995_at | 0.3454 | 0.4068 | |
| GSE97050 | CDK5R1 | 8851 | A_33_P3226985 | 0.1173 | 0.7514 | |
| SRP007169 | CDK5R1 | 8851 | RNAseq | -0.8411 | 0.0075 | |
| SRP008496 | CDK5R1 | 8851 | RNAseq | -0.9048 | 0.0029 | |
| SRP064894 | CDK5R1 | 8851 | RNAseq | 0.0686 | 0.8585 | |
| SRP133303 | CDK5R1 | 8851 | RNAseq | -0.3710 | 0.3403 | |
| SRP159526 | CDK5R1 | 8851 | RNAseq | -0.5815 | 0.2006 | |
| SRP193095 | CDK5R1 | 8851 | RNAseq | -0.1169 | 0.6330 | |
| SRP219564 | CDK5R1 | 8851 | RNAseq | -0.2348 | 0.7917 | |
| TCGA | CDK5R1 | 8851 | RNAseq | 0.7182 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDK5R1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDK5R1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDK5R1 | 8851 | 9 | 2 | 19 | |
| GSE20123 | CDK5R1 | 8851 | 9 | 2 | 19 | |
| GSE43470 | CDK5R1 | 8851 | 1 | 1 | 41 | |
| GSE46452 | CDK5R1 | 8851 | 33 | 1 | 25 | |
| GSE47630 | CDK5R1 | 8851 | 7 | 1 | 32 | |
| GSE54993 | CDK5R1 | 8851 | 3 | 3 | 64 | |
| GSE54994 | CDK5R1 | 8851 | 7 | 6 | 40 | |
| GSE60625 | CDK5R1 | 8851 | 4 | 0 | 7 | |
| GSE74703 | CDK5R1 | 8851 | 1 | 1 | 34 | |
| GSE74704 | CDK5R1 | 8851 | 6 | 2 | 12 | |
| TCGA | CDK5R1 | 8851 | 19 | 9 | 68 |
Total number of gains: 99; Total number of losses: 28; Total Number of normals: 361.
Somatic mutations of CDK5R1:
Generating mutation plots.
Highly correlated genes for CDK5R1:
Showing top 20/571 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDK5R1 | PLEKHA2 | 0.754151 | 3 | 0 | 3 |
| CDK5R1 | SRXN1 | 0.728359 | 3 | 0 | 3 |
| CDK5R1 | PTBP3 | 0.717803 | 7 | 0 | 7 |
| CDK5R1 | CRLF3 | 0.710763 | 6 | 0 | 5 |
| CDK5R1 | KCNK6 | 0.706075 | 5 | 0 | 4 |
| CDK5R1 | RETSAT | 0.695137 | 3 | 0 | 3 |
| CDK5R1 | S1PR5 | 0.694751 | 4 | 0 | 3 |
| CDK5R1 | FOPNL | 0.691229 | 4 | 0 | 4 |
| CDK5R1 | PNPO | 0.688123 | 3 | 0 | 3 |
| CDK5R1 | ABCB6 | 0.685512 | 4 | 0 | 4 |
| CDK5R1 | ACTR2 | 0.673757 | 4 | 0 | 4 |
| CDK5R1 | HMGA1 | 0.671749 | 4 | 0 | 3 |
| CDK5R1 | CDK5RAP2 | 0.670801 | 3 | 0 | 3 |
| CDK5R1 | NHSL1 | 0.67079 | 5 | 0 | 5 |
| CDK5R1 | TMEM167A | 0.670778 | 4 | 0 | 3 |
| CDK5R1 | ARHGEF37 | 0.6704 | 3 | 0 | 3 |
| CDK5R1 | IPMK | 0.670052 | 4 | 0 | 3 |
| CDK5R1 | SF3B4 | 0.669208 | 3 | 0 | 3 |
| CDK5R1 | F12 | 0.666897 | 5 | 0 | 4 |
| CDK5R1 | GSKIP | 0.665134 | 3 | 0 | 3 |
For details and further investigation, click here
