| Full name: claudin 7 | Alias Symbol: Hs.84359 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 1366 | HGNC ID: HGNC:2049 | Ensembl Gene: ENSG00000181885 | OMIM ID: 609131 |
| Drug and gene relationship at DGIdb | |||
CLDN7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN7 | 1366 | 202790_at | -0.9182 | 0.1564 | |
| GSE20347 | CLDN7 | 1366 | 202790_at | -1.5181 | 0.0000 | |
| GSE23400 | CLDN7 | 1366 | 202790_at | -1.3192 | 0.0000 | |
| GSE26886 | CLDN7 | 1366 | 202790_at | -2.3771 | 0.0000 | |
| GSE29001 | CLDN7 | 1366 | 202790_at | -1.7648 | 0.0000 | |
| GSE38129 | CLDN7 | 1366 | 202790_at | -0.5319 | 0.2062 | |
| GSE45670 | CLDN7 | 1366 | 202790_at | -0.5258 | 0.1055 | |
| GSE53622 | CLDN7 | 1366 | 48508 | -1.4854 | 0.0001 | |
| GSE53624 | CLDN7 | 1366 | 48508 | -2.2359 | 0.0000 | |
| GSE63941 | CLDN7 | 1366 | 202790_at | 4.1591 | 0.0030 | |
| GSE77861 | CLDN7 | 1366 | 202790_at | -0.9821 | 0.0271 | |
| GSE97050 | CLDN7 | A_21_P0000099 | 0.5038 | 0.6102 | ||
| SRP007169 | CLDN7 | 1366 | RNAseq | -1.8757 | 0.0000 | |
| SRP008496 | CLDN7 | 1366 | RNAseq | -2.8035 | 0.0000 | |
| SRP064894 | CLDN7 | 1366 | RNAseq | -1.9156 | 0.0000 | |
| SRP133303 | CLDN7 | 1366 | RNAseq | -1.5966 | 0.0001 | |
| SRP159526 | CLDN7 | 1366 | RNAseq | -1.7544 | 0.0002 | |
| SRP193095 | CLDN7 | 1366 | RNAseq | -1.3434 | 0.0000 | |
| SRP219564 | CLDN7 | 1366 | RNAseq | -1.0090 | 0.3543 | |
| TCGA | CLDN7 | 1366 | RNAseq | 0.9921 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 12.
Survival by CLDN7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN7 | 1366 | 4 | 2 | 24 | |
| GSE20123 | CLDN7 | 1366 | 4 | 3 | 23 | |
| GSE43470 | CLDN7 | 1366 | 1 | 4 | 38 | |
| GSE46452 | CLDN7 | 1366 | 34 | 1 | 24 | |
| GSE47630 | CLDN7 | 1366 | 7 | 1 | 32 | |
| GSE54993 | CLDN7 | 1366 | 4 | 3 | 63 | |
| GSE54994 | CLDN7 | 1366 | 5 | 8 | 40 | |
| GSE60625 | CLDN7 | 1366 | 4 | 0 | 7 | |
| GSE74703 | CLDN7 | 1366 | 1 | 2 | 33 | |
| GSE74704 | CLDN7 | 1366 | 2 | 1 | 17 | |
| TCGA | CLDN7 | 1366 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of CLDN7:
Generating mutation plots.
Highly correlated genes for CLDN7:
Showing top 20/1327 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN7 | PLEKHA7 | 0.808347 | 7 | 0 | 7 |
| CLDN7 | RAB25 | 0.803552 | 13 | 0 | 13 |
| CLDN7 | FUT3 | 0.79385 | 13 | 0 | 13 |
| CLDN7 | RIPK4 | 0.782682 | 9 | 0 | 9 |
| CLDN7 | NT5C2 | 0.78186 | 11 | 0 | 11 |
| CLDN7 | ARAP2 | 0.776785 | 3 | 0 | 3 |
| CLDN7 | SMAGP | 0.772727 | 13 | 0 | 12 |
| CLDN7 | ARHGAP32 | 0.772235 | 11 | 0 | 11 |
| CLDN7 | EVPL | 0.772083 | 12 | 0 | 12 |
| CLDN7 | PRSS3 | 0.771706 | 11 | 0 | 11 |
| CLDN7 | EPHA1 | 0.768274 | 12 | 0 | 12 |
| CLDN7 | LIPH | 0.767041 | 8 | 0 | 8 |
| CLDN7 | MACC1 | 0.763231 | 8 | 0 | 8 |
| CLDN7 | ZDHHC13 | 0.762996 | 12 | 0 | 11 |
| CLDN7 | UPK3B | 0.762406 | 3 | 0 | 3 |
| CLDN7 | ELF3 | 0.758904 | 13 | 0 | 13 |
| CLDN7 | RBM47 | 0.758066 | 13 | 0 | 12 |
| CLDN7 | EPS8L2 | 0.753801 | 11 | 0 | 10 |
| CLDN7 | PCBP1-AS1 | 0.753477 | 3 | 0 | 3 |
| CLDN7 | CXCR2 | 0.751758 | 10 | 0 | 10 |
For details and further investigation, click here
