KLF5

 

Full name: Kruppel like factor 5 Alias Symbol: IKLF|CKLF
Type: protein-coding gene Cytoband: 13q22.1
Entrez ID: 688 HGNC ID: HGNC:6349 Ensembl Gene: ENSG00000102554 OMIM ID: 602903
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 53/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of KLF5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KLF5 688 209212_s_at -0.2982 0.7538
GSE20347 KLF5 688 209211_at -0.7258 0.0158
GSE23400 KLF5 688 209212_s_at -0.6126 0.0112
GSE26886 KLF5 688 209211_at -1.1367 0.0000
GSE29001 KLF5 688 209212_s_at -0.9585 0.0095
GSE38129 KLF5 688 209212_s_at -0.1453 0.7931
GSE45670 KLF5 688 209211_at -0.0981 0.6421
GSE53622 KLF5 688 12255 -0.9835 0.0000
GSE53624 KLF5 688 12255 -1.3010 0.0000
GSE63941 KLF5 688 209211_at 3.6596 0.0002
GSE77861 KLF5 688 209211_at -0.7163 0.0914
GSE97050 KLF5 688 A_23_P53891 0.0626 0.9472
SRP007169 KLF5 688 RNAseq -2.0589 0.0000
SRP008496 KLF5 688 RNAseq -1.7374 0.0001
SRP064894 KLF5 688 RNAseq -1.5608 0.0001
SRP133303 KLF5 688 RNAseq -0.7373 0.0165
SRP159526 KLF5 688 RNAseq -0.8817 0.1105
SRP193095 KLF5 688 RNAseq -0.9787 0.0000
SRP219564 KLF5 688 RNAseq -1.2353 0.2068
TCGA KLF5 688 RNAseq 0.2791 0.0071

Upregulated datasets: 1; Downregulated datasets: 5.  

 

Survival by KLF5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of KLF5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KLF5 688 4 10 16
GSE20123 KLF5 688 4 8 18
GSE43470 KLF5 688 4 10 29
GSE46452 KLF5 688 2 31 26
GSE47630 KLF5 688 3 26 11
GSE54993 KLF5 688 11 3 56
GSE54994 KLF5 688 4 13 36
GSE60625 KLF5 688 0 3 8
GSE74703 KLF5 688 3 8 25
GSE74704 KLF5 688 2 7 11
TCGA KLF5 688 19 27 50

Total number of gains: 56; Total number of losses: 146; Total Number of normals: 286.  

 

Somatic mutations of KLF5:

 

Generating mutation plots.

 

Highly correlated genes for KLF5:

 

Showing top 20/1021 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KLF5CNFN0.825694505
KLF5ARAP20.808951303
KLF5SPRR2D0.778746303
KLF5PGLYRP30.775968303
KLF5AZI20.770185303
KLF5S100A160.766647706
KLF5SPRR2A0.766628303
KLF5SPRR2E0.765224303
KLF5SPRR2F0.765011303
KLF5TMPRSS11A0.759737303
KLF5DSG30.75943612012
KLF5TMEM1540.756176707
KLF5NCCRP10.750958303
KLF5ANXA10.7397991009
KLF5TRIM290.73967612011
KLF5SPRR2B0.737117303
KLF5NIPAL10.731306303
KLF5KRT6C0.729804303
KLF5SLC9A3R10.72905312012
KLF5SDCBP20.727844303

For details and further investigation, click here