| Full name: transmembrane serine protease 4 | Alias Symbol: TMPRSS3|MT-SP2 | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 56649 | HGNC ID: HGNC:11878 | Ensembl Gene: ENSG00000137648 | OMIM ID: 606565 |
| Drug and gene relationship at DGIdb | |||
Expression of TMPRSS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMPRSS4 | 56649 | 218960_at | -0.5240 | 0.6653 | |
| GSE20347 | TMPRSS4 | 56649 | 218960_at | -0.8380 | 0.0286 | |
| GSE23400 | TMPRSS4 | 56649 | 218960_at | -0.4128 | 0.0324 | |
| GSE26886 | TMPRSS4 | 56649 | 218960_at | -1.0687 | 0.0048 | |
| GSE29001 | TMPRSS4 | 56649 | 218960_at | -1.2061 | 0.0088 | |
| GSE38129 | TMPRSS4 | 56649 | 218960_at | -0.2475 | 0.6632 | |
| GSE45670 | TMPRSS4 | 56649 | 218960_at | 0.5788 | 0.0616 | |
| GSE53622 | TMPRSS4 | 56649 | 134936 | -0.5816 | 0.0808 | |
| GSE53624 | TMPRSS4 | 56649 | 134936 | -1.0832 | 0.0000 | |
| GSE63941 | TMPRSS4 | 56649 | 218960_at | 3.4750 | 0.0253 | |
| GSE77861 | TMPRSS4 | 56649 | 218960_at | 0.3025 | 0.2547 | |
| GSE97050 | TMPRSS4 | 56649 | A_33_P3296846 | 0.2349 | 0.7807 | |
| SRP007169 | TMPRSS4 | 56649 | RNAseq | -0.9123 | 0.1137 | |
| SRP008496 | TMPRSS4 | 56649 | RNAseq | -1.5545 | 0.0001 | |
| SRP064894 | TMPRSS4 | 56649 | RNAseq | -1.0397 | 0.0260 | |
| SRP133303 | TMPRSS4 | 56649 | RNAseq | -0.2819 | 0.4254 | |
| SRP159526 | TMPRSS4 | 56649 | RNAseq | -0.4419 | 0.6150 | |
| SRP193095 | TMPRSS4 | 56649 | RNAseq | -1.1848 | 0.0000 | |
| SRP219564 | TMPRSS4 | 56649 | RNAseq | -1.0150 | 0.3256 | |
| TCGA | TMPRSS4 | 56649 | RNAseq | 0.5364 | 0.0106 |
Upregulated datasets: 1; Downregulated datasets: 6.
Survival by TMPRSS4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMPRSS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMPRSS4 | 56649 | 2 | 11 | 17 | |
| GSE20123 | TMPRSS4 | 56649 | 2 | 11 | 17 | |
| GSE43470 | TMPRSS4 | 56649 | 2 | 9 | 32 | |
| GSE46452 | TMPRSS4 | 56649 | 3 | 26 | 30 | |
| GSE47630 | TMPRSS4 | 56649 | 2 | 19 | 19 | |
| GSE54993 | TMPRSS4 | 56649 | 10 | 0 | 60 | |
| GSE54994 | TMPRSS4 | 56649 | 6 | 19 | 28 | |
| GSE60625 | TMPRSS4 | 56649 | 0 | 3 | 8 | |
| GSE74703 | TMPRSS4 | 56649 | 1 | 6 | 29 | |
| GSE74704 | TMPRSS4 | 56649 | 1 | 7 | 12 | |
| TCGA | TMPRSS4 | 56649 | 5 | 50 | 41 |
Total number of gains: 34; Total number of losses: 161; Total Number of normals: 293.
Somatic mutations of TMPRSS4:
Generating mutation plots.
Highly correlated genes for TMPRSS4:
Showing top 20/452 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMPRSS4 | CLDN4 | 0.724929 | 10 | 0 | 10 |
| TMPRSS4 | RAPGEFL1 | 0.716179 | 11 | 0 | 10 |
| TMPRSS4 | TMPRSS11A | 0.715878 | 3 | 0 | 3 |
| TMPRSS4 | ARAP2 | 0.71098 | 3 | 0 | 3 |
| TMPRSS4 | KRT16 | 0.710707 | 3 | 0 | 3 |
| TMPRSS4 | SCNN1A | 0.70794 | 12 | 0 | 10 |
| TMPRSS4 | KLF5 | 0.699878 | 11 | 0 | 10 |
| TMPRSS4 | BTBD11 | 0.6923 | 5 | 0 | 5 |
| TMPRSS4 | SLC9A3R1 | 0.690551 | 12 | 0 | 10 |
| TMPRSS4 | ELF3 | 0.690494 | 12 | 0 | 11 |
| TMPRSS4 | GRHL1 | 0.688028 | 6 | 0 | 5 |
| TMPRSS4 | RHOV | 0.68459 | 6 | 0 | 5 |
| TMPRSS4 | GRHL3 | 0.682103 | 7 | 0 | 6 |
| TMPRSS4 | EPHA1 | 0.681532 | 11 | 0 | 10 |
| TMPRSS4 | NHSL1 | 0.678446 | 3 | 0 | 3 |
| TMPRSS4 | SH3RF2 | 0.678427 | 4 | 0 | 3 |
| TMPRSS4 | FAM83C | 0.678299 | 4 | 0 | 3 |
| TMPRSS4 | SPRR2D | 0.676444 | 3 | 0 | 3 |
| TMPRSS4 | CNOT11 | 0.67553 | 5 | 0 | 5 |
| TMPRSS4 | KRT80 | 0.674081 | 6 | 0 | 5 |
For details and further investigation, click here
