| Full name: tRNA splicing endonuclease subunit 54 | Alias Symbol: SEN54|SEN54L | ||
| Type: protein-coding gene | Cytoband: 17q25.1 | ||
| Entrez ID: 283989 | HGNC ID: HGNC:27561 | Ensembl Gene: ENSG00000182173 | OMIM ID: 608755 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TSEN54:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TSEN54 | 283989 | 225879_at | 0.6671 | 0.1698 | |
| GSE26886 | TSEN54 | 283989 | 225879_at | 0.2938 | 0.0031 | |
| GSE45670 | TSEN54 | 283989 | 225879_at | 0.2688 | 0.0523 | |
| GSE53622 | TSEN54 | 283989 | 58275 | -0.3172 | 0.0006 | |
| GSE53624 | TSEN54 | 283989 | 58275 | 0.0074 | 0.9123 | |
| GSE63941 | TSEN54 | 283989 | 225879_at | 1.5046 | 0.0001 | |
| GSE77861 | TSEN54 | 283989 | 225879_at | 0.4553 | 0.0743 | |
| GSE97050 | TSEN54 | 283989 | A_23_P147277 | 0.2774 | 0.4285 | |
| SRP007169 | TSEN54 | 283989 | RNAseq | 0.1372 | 0.7113 | |
| SRP008496 | TSEN54 | 283989 | RNAseq | -0.0117 | 0.9627 | |
| SRP064894 | TSEN54 | 283989 | RNAseq | 0.3961 | 0.0939 | |
| SRP133303 | TSEN54 | 283989 | RNAseq | 0.3855 | 0.2030 | |
| SRP159526 | TSEN54 | 283989 | RNAseq | 0.3882 | 0.0085 | |
| SRP193095 | TSEN54 | 283989 | RNAseq | 0.1724 | 0.0887 | |
| SRP219564 | TSEN54 | 283989 | RNAseq | 0.9177 | 0.1486 | |
| TCGA | TSEN54 | 283989 | RNAseq | 0.1593 | 0.0106 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TSEN54 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TSEN54:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TSEN54 | 283989 | 6 | 2 | 22 | |
| GSE20123 | TSEN54 | 283989 | 6 | 2 | 22 | |
| GSE43470 | TSEN54 | 283989 | 5 | 3 | 35 | |
| GSE46452 | TSEN54 | 283989 | 34 | 0 | 25 | |
| GSE47630 | TSEN54 | 283989 | 8 | 1 | 31 | |
| GSE54993 | TSEN54 | 283989 | 2 | 5 | 63 | |
| GSE54994 | TSEN54 | 283989 | 10 | 4 | 39 | |
| GSE60625 | TSEN54 | 283989 | 6 | 0 | 5 | |
| GSE74703 | TSEN54 | 283989 | 5 | 1 | 30 | |
| GSE74704 | TSEN54 | 283989 | 4 | 1 | 15 | |
| TCGA | TSEN54 | 283989 | 31 | 10 | 55 |
Total number of gains: 117; Total number of losses: 29; Total Number of normals: 342.
Somatic mutations of TSEN54:
Generating mutation plots.
Highly correlated genes for TSEN54:
Showing top 20/507 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TSEN54 | LSM4 | 0.739998 | 4 | 0 | 4 |
| TSEN54 | SLC25A19 | 0.737187 | 5 | 0 | 4 |
| TSEN54 | DDOST | 0.735549 | 3 | 0 | 3 |
| TSEN54 | ENO1 | 0.734856 | 3 | 0 | 3 |
| TSEN54 | CCDC77 | 0.729863 | 3 | 0 | 3 |
| TSEN54 | ADAM15 | 0.723274 | 3 | 0 | 3 |
| TSEN54 | ST14 | 0.717923 | 4 | 0 | 4 |
| TSEN54 | GSTP1 | 0.714413 | 3 | 0 | 3 |
| TSEN54 | GPR160 | 0.705481 | 3 | 0 | 3 |
| TSEN54 | ITGB4 | 0.704649 | 3 | 0 | 3 |
| TSEN54 | DSG2 | 0.702264 | 4 | 0 | 3 |
| TSEN54 | LAMB3 | 0.696752 | 4 | 0 | 4 |
| TSEN54 | WRNIP1 | 0.695902 | 3 | 0 | 3 |
| TSEN54 | TMEM161A | 0.695717 | 3 | 0 | 3 |
| TSEN54 | RPUSD1 | 0.693559 | 5 | 0 | 5 |
| TSEN54 | CCDC137 | 0.692662 | 4 | 0 | 3 |
| TSEN54 | MRPS7 | 0.692374 | 4 | 0 | 4 |
| TSEN54 | KIAA1522 | 0.691118 | 4 | 0 | 4 |
| TSEN54 | NUP85 | 0.688618 | 7 | 0 | 6 |
| TSEN54 | ABCC10 | 0.688518 | 3 | 0 | 3 |
For details and further investigation, click here
