| Full name: cystatin A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q21.1 | ||
| Entrez ID: 1475 | HGNC ID: HGNC:2481 | Ensembl Gene: ENSG00000121552 | OMIM ID: 184600 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CSTA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CSTA | 1475 | 204971_at | -0.6880 | 0.1928 | |
| GSE20347 | CSTA | 1475 | 204971_at | -0.9836 | 0.0000 | |
| GSE23400 | CSTA | 1475 | 204971_at | -1.2801 | 0.0000 | |
| GSE26886 | CSTA | 1475 | 204971_at | -1.6665 | 0.0000 | |
| GSE29001 | CSTA | 1475 | 204971_at | -0.9267 | 0.0013 | |
| GSE38129 | CSTA | 1475 | 204971_at | -0.3633 | 0.5871 | |
| GSE45670 | CSTA | 1475 | 204971_at | -0.3685 | 0.0201 | |
| GSE63941 | CSTA | 1475 | 204971_at | 3.8168 | 0.1225 | |
| GSE77861 | CSTA | 1475 | 204971_at | -0.7630 | 0.0488 | |
| GSE97050 | CSTA | 1475 | A_23_P41114 | -0.8417 | 0.5410 | |
| SRP007169 | CSTA | 1475 | RNAseq | -5.6554 | 0.0000 | |
| SRP008496 | CSTA | 1475 | RNAseq | -5.0310 | 0.0000 | |
| SRP064894 | CSTA | 1475 | RNAseq | -4.0730 | 0.0000 | |
| SRP133303 | CSTA | 1475 | RNAseq | -3.8805 | 0.0000 | |
| SRP159526 | CSTA | 1475 | RNAseq | -4.2843 | 0.0000 | |
| SRP193095 | CSTA | 1475 | RNAseq | -3.9903 | 0.0000 | |
| SRP219564 | CSTA | 1475 | RNAseq | -4.5572 | 0.0003 | |
| TCGA | CSTA | 1475 | RNAseq | 0.6543 | 0.0007 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by CSTA expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CSTA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CSTA | 1475 | 18 | 0 | 12 | |
| GSE20123 | CSTA | 1475 | 18 | 0 | 12 | |
| GSE43470 | CSTA | 1475 | 20 | 0 | 23 | |
| GSE46452 | CSTA | 1475 | 14 | 5 | 40 | |
| GSE47630 | CSTA | 1475 | 16 | 5 | 19 | |
| GSE54993 | CSTA | 1475 | 2 | 6 | 62 | |
| GSE54994 | CSTA | 1475 | 30 | 4 | 19 | |
| GSE60625 | CSTA | 1475 | 0 | 6 | 5 | |
| GSE74703 | CSTA | 1475 | 16 | 0 | 20 | |
| GSE74704 | CSTA | 1475 | 13 | 0 | 7 | |
| TCGA | CSTA | 1475 | 54 | 6 | 36 |
Total number of gains: 201; Total number of losses: 32; Total Number of normals: 255.
Somatic mutations of CSTA:
Generating mutation plots.
Highly correlated genes for CSTA:
Showing top 20/1095 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CSTA | CYSRT1 | 0.878754 | 4 | 0 | 4 |
| CSTA | SCEL | 0.840443 | 10 | 0 | 10 |
| CSTA | A2ML1 | 0.833982 | 6 | 0 | 6 |
| CSTA | RAB11A | 0.83239 | 8 | 0 | 8 |
| CSTA | TMPRSS11E | 0.830911 | 9 | 0 | 9 |
| CSTA | IL1RN | 0.825752 | 11 | 0 | 11 |
| CSTA | CSTB | 0.825572 | 10 | 0 | 10 |
| CSTA | SPRR1A | 0.815085 | 10 | 0 | 10 |
| CSTA | ANXA1 | 0.808479 | 10 | 0 | 10 |
| CSTA | SMIM5 | 0.808392 | 4 | 0 | 4 |
| CSTA | ACPP | 0.807677 | 10 | 0 | 10 |
| CSTA | TGM1 | 0.801407 | 10 | 0 | 10 |
| CSTA | SPRR3 | 0.79848 | 10 | 0 | 9 |
| CSTA | TMPRSS11B | 0.79548 | 6 | 0 | 5 |
| CSTA | SPINK7 | 0.795336 | 6 | 0 | 6 |
| CSTA | ZNF185 | 0.794968 | 10 | 0 | 10 |
| CSTA | PPL | 0.793463 | 11 | 0 | 11 |
| CSTA | S100A16 | 0.78791 | 6 | 0 | 6 |
| CSTA | SPINK5 | 0.78709 | 11 | 0 | 11 |
| CSTA | CNFN | 0.786566 | 6 | 0 | 6 |
For details and further investigation, click here
