| Full name: F-box and leucine rich repeat protein 2 | Alias Symbol: FBL2|FBL3 | ||
| Type: protein-coding gene | Cytoband: 3p22.3 | ||
| Entrez ID: 25827 | HGNC ID: HGNC:13598 | Ensembl Gene: ENSG00000153558 | OMIM ID: 605652 |
| Drug and gene relationship at DGIdb | |||
Expression of FBXL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXL2 | 25827 | 214436_at | 0.5889 | 0.1672 | |
| GSE20347 | FBXL2 | 25827 | 214436_at | 0.6536 | 0.0015 | |
| GSE23400 | FBXL2 | 25827 | 214436_at | 0.1870 | 0.0003 | |
| GSE26886 | FBXL2 | 25827 | 214436_at | 0.9738 | 0.0004 | |
| GSE29001 | FBXL2 | 25827 | 214436_at | 0.2410 | 0.3668 | |
| GSE38129 | FBXL2 | 25827 | 214436_at | 0.2160 | 0.2620 | |
| GSE45670 | FBXL2 | 25827 | 214436_at | -0.1211 | 0.7746 | |
| GSE53622 | FBXL2 | 25827 | 108358 | 0.6999 | 0.0000 | |
| GSE53624 | FBXL2 | 25827 | 142160 | 0.7702 | 0.0000 | |
| GSE63941 | FBXL2 | 25827 | 214436_at | -0.6479 | 0.2475 | |
| GSE77861 | FBXL2 | 25827 | 214436_at | 0.0460 | 0.7914 | |
| GSE97050 | FBXL2 | 25827 | A_23_P17955 | -0.0773 | 0.7400 | |
| SRP007169 | FBXL2 | 25827 | RNAseq | 1.7426 | 0.0073 | |
| SRP008496 | FBXL2 | 25827 | RNAseq | 2.2165 | 0.0000 | |
| SRP064894 | FBXL2 | 25827 | RNAseq | 0.5801 | 0.0017 | |
| SRP133303 | FBXL2 | 25827 | RNAseq | 0.3123 | 0.0295 | |
| SRP159526 | FBXL2 | 25827 | RNAseq | 0.0204 | 0.9633 | |
| SRP193095 | FBXL2 | 25827 | RNAseq | 0.6111 | 0.0000 | |
| SRP219564 | FBXL2 | 25827 | RNAseq | 0.2505 | 0.4913 | |
| TCGA | FBXL2 | 25827 | RNAseq | 0.0281 | 0.8406 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by FBXL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXL2 | 25827 | 0 | 18 | 12 | |
| GSE20123 | FBXL2 | 25827 | 0 | 18 | 12 | |
| GSE43470 | FBXL2 | 25827 | 1 | 19 | 23 | |
| GSE46452 | FBXL2 | 25827 | 2 | 17 | 40 | |
| GSE47630 | FBXL2 | 25827 | 1 | 25 | 14 | |
| GSE54993 | FBXL2 | 25827 | 6 | 3 | 61 | |
| GSE54994 | FBXL2 | 25827 | 1 | 32 | 20 | |
| GSE60625 | FBXL2 | 25827 | 5 | 0 | 6 | |
| GSE74703 | FBXL2 | 25827 | 1 | 16 | 19 | |
| GSE74704 | FBXL2 | 25827 | 0 | 12 | 8 | |
| TCGA | FBXL2 | 25827 | 1 | 69 | 26 |
Total number of gains: 18; Total number of losses: 229; Total Number of normals: 241.
Somatic mutations of FBXL2:
Generating mutation plots.
Highly correlated genes for FBXL2:
Showing top 20/159 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXL2 | DNAJC30 | 0.650459 | 3 | 0 | 3 |
| FBXL2 | RIMS3 | 0.646632 | 5 | 0 | 4 |
| FBXL2 | SLC25A30 | 0.623304 | 3 | 0 | 3 |
| FBXL2 | ETV1 | 0.621664 | 4 | 0 | 3 |
| FBXL2 | EFR3A | 0.618481 | 4 | 0 | 3 |
| FBXL2 | KIF9 | 0.608855 | 3 | 0 | 3 |
| FBXL2 | FSD1L | 0.603654 | 5 | 0 | 4 |
| FBXL2 | INHBA | 0.596378 | 10 | 0 | 8 |
| FBXL2 | ZNF239 | 0.595514 | 5 | 0 | 3 |
| FBXL2 | TXNRD2 | 0.595482 | 5 | 0 | 3 |
| FBXL2 | PDGFC | 0.593453 | 8 | 0 | 7 |
| FBXL2 | RILPL1 | 0.590402 | 4 | 0 | 3 |
| FBXL2 | APP | 0.589608 | 10 | 0 | 8 |
| FBXL2 | MYH10 | 0.587199 | 11 | 0 | 9 |
| FBXL2 | NREP | 0.583551 | 10 | 0 | 7 |
| FBXL2 | IFT81 | 0.58321 | 6 | 0 | 5 |
| FBXL2 | RNF115 | 0.583197 | 3 | 0 | 3 |
| FBXL2 | CEP290 | 0.58225 | 8 | 0 | 6 |
| FBXL2 | COL4A5 | 0.581169 | 7 | 0 | 6 |
| FBXL2 | FEZ2 | 0.577312 | 5 | 0 | 3 |
For details and further investigation, click here
