| Full name: platelet derived growth factor C | Alias Symbol: SCDGF|fallotein | ||
| Type: protein-coding gene | Cytoband: 4q32.1 | ||
| Entrez ID: 56034 | HGNC ID: HGNC:8801 | Ensembl Gene: ENSG00000145431 | OMIM ID: 608452 |
| Drug and gene relationship at DGIdb | |||
PDGFC involved pathways:
Expression of PDGFC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDGFC | 56034 | 218718_at | -0.3819 | 0.6260 | |
| GSE20347 | PDGFC | 56034 | 218718_at | 0.7418 | 0.0753 | |
| GSE23400 | PDGFC | 56034 | 218718_at | 0.6931 | 0.0016 | |
| GSE26886 | PDGFC | 56034 | 218718_at | 2.6138 | 0.0001 | |
| GSE29001 | PDGFC | 56034 | 218718_at | 0.8333 | 0.2225 | |
| GSE38129 | PDGFC | 56034 | 218718_at | 0.6036 | 0.0884 | |
| GSE45670 | PDGFC | 56034 | 218718_at | -0.7660 | 0.1527 | |
| GSE53622 | PDGFC | 56034 | 9156 | 0.6877 | 0.0000 | |
| GSE53624 | PDGFC | 56034 | 109454 | 0.9010 | 0.0000 | |
| GSE63941 | PDGFC | 56034 | 218718_at | -1.6577 | 0.2055 | |
| GSE77861 | PDGFC | 56034 | 218718_at | 0.6960 | 0.3419 | |
| GSE97050 | PDGFC | 56034 | A_23_P58396 | 0.4087 | 0.4110 | |
| SRP007169 | PDGFC | 56034 | RNAseq | 1.9537 | 0.0006 | |
| SRP008496 | PDGFC | 56034 | RNAseq | 2.3712 | 0.0000 | |
| SRP064894 | PDGFC | 56034 | RNAseq | 0.4247 | 0.1356 | |
| SRP133303 | PDGFC | 56034 | RNAseq | 1.3357 | 0.0000 | |
| SRP159526 | PDGFC | 56034 | RNAseq | 0.6201 | 0.1467 | |
| SRP193095 | PDGFC | 56034 | RNAseq | 0.9809 | 0.0001 | |
| SRP219564 | PDGFC | 56034 | RNAseq | 0.2767 | 0.6801 | |
| TCGA | PDGFC | 56034 | RNAseq | -0.0061 | 0.9610 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by PDGFC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDGFC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDGFC | 56034 | 0 | 14 | 16 | |
| GSE20123 | PDGFC | 56034 | 0 | 14 | 16 | |
| GSE43470 | PDGFC | 56034 | 0 | 14 | 29 | |
| GSE46452 | PDGFC | 56034 | 1 | 36 | 22 | |
| GSE47630 | PDGFC | 56034 | 0 | 23 | 17 | |
| GSE54993 | PDGFC | 56034 | 10 | 0 | 60 | |
| GSE54994 | PDGFC | 56034 | 1 | 12 | 40 | |
| GSE60625 | PDGFC | 56034 | 0 | 1 | 10 | |
| GSE74703 | PDGFC | 56034 | 0 | 12 | 24 | |
| GSE74704 | PDGFC | 56034 | 0 | 7 | 13 | |
| TCGA | PDGFC | 56034 | 11 | 36 | 49 |
Total number of gains: 23; Total number of losses: 169; Total Number of normals: 296.
Somatic mutations of PDGFC:
Generating mutation plots.
Highly correlated genes for PDGFC:
Showing top 20/951 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDGFC | GLIS2 | 0.739459 | 6 | 0 | 6 |
| PDGFC | TBC1D28 | 0.735712 | 3 | 0 | 3 |
| PDGFC | PET117 | 0.725219 | 3 | 0 | 3 |
| PDGFC | BIRC6 | 0.724849 | 3 | 0 | 3 |
| PDGFC | SPIRE1 | 0.719354 | 4 | 0 | 3 |
| PDGFC | CPSF3 | 0.707099 | 3 | 0 | 3 |
| PDGFC | RRM2B | 0.705047 | 3 | 0 | 3 |
| PDGFC | GAS1 | 0.692752 | 11 | 0 | 11 |
| PDGFC | FSTL1 | 0.692267 | 12 | 0 | 11 |
| PDGFC | TNS4 | 0.691012 | 3 | 0 | 3 |
| PDGFC | LGALS1 | 0.688727 | 12 | 0 | 12 |
| PDGFC | TM4SF18 | 0.686705 | 3 | 0 | 3 |
| PDGFC | FKBP7 | 0.686009 | 6 | 0 | 6 |
| PDGFC | EFEMP2 | 0.683954 | 11 | 0 | 9 |
| PDGFC | KLHL31 | 0.682378 | 3 | 0 | 3 |
| PDGFC | DOCK11 | 0.681352 | 6 | 0 | 5 |
| PDGFC | SLC25A37 | 0.680423 | 3 | 0 | 3 |
| PDGFC | IGFBP7 | 0.680307 | 12 | 0 | 11 |
| PDGFC | ITGB1 | 0.67884 | 12 | 0 | 11 |
| PDGFC | PDK1 | 0.678679 | 3 | 0 | 3 |
For details and further investigation, click here
