| Full name: thioredoxin reductase 2 | Alias Symbol: TR|TRXR2|TR3 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 10587 | HGNC ID: HGNC:18155 | Ensembl Gene: ENSG00000184470 | OMIM ID: 606448 |
| Drug and gene relationship at DGIdb | |||
Expression of TXNRD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TXNRD2 | 10587 | 211177_s_at | 0.3935 | 0.1225 | |
| GSE20347 | TXNRD2 | 10587 | 211177_s_at | 0.1013 | 0.1982 | |
| GSE23400 | TXNRD2 | 10587 | 211177_s_at | 0.0728 | 0.1144 | |
| GSE26886 | TXNRD2 | 10587 | 211177_s_at | 0.4012 | 0.0052 | |
| GSE29001 | TXNRD2 | 10587 | 211177_s_at | 0.2382 | 0.2490 | |
| GSE38129 | TXNRD2 | 10587 | 211177_s_at | 0.1127 | 0.1869 | |
| GSE45670 | TXNRD2 | 10587 | 211177_s_at | 0.1298 | 0.1041 | |
| GSE53622 | TXNRD2 | 10587 | 88792 | 0.3482 | 0.0000 | |
| GSE53624 | TXNRD2 | 10587 | 45835 | 0.6359 | 0.0000 | |
| GSE63941 | TXNRD2 | 10587 | 211177_s_at | 0.1997 | 0.7306 | |
| GSE77861 | TXNRD2 | 10587 | 211177_s_at | 0.2091 | 0.1103 | |
| GSE97050 | TXNRD2 | 10587 | A_23_P102988 | -0.0116 | 0.9639 | |
| SRP007169 | TXNRD2 | 10587 | RNAseq | 0.7773 | 0.1123 | |
| SRP008496 | TXNRD2 | 10587 | RNAseq | 1.2613 | 0.0011 | |
| SRP064894 | TXNRD2 | 10587 | RNAseq | 1.0801 | 0.0000 | |
| SRP133303 | TXNRD2 | 10587 | RNAseq | 0.1648 | 0.1168 | |
| SRP159526 | TXNRD2 | 10587 | RNAseq | 0.4937 | 0.1052 | |
| SRP193095 | TXNRD2 | 10587 | RNAseq | 0.4236 | 0.0017 | |
| SRP219564 | TXNRD2 | 10587 | RNAseq | 0.4755 | 0.2556 | |
| TCGA | TXNRD2 | 10587 | RNAseq | -0.2589 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TXNRD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TXNRD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TXNRD2 | 10587 | 5 | 7 | 18 | |
| GSE20123 | TXNRD2 | 10587 | 5 | 7 | 18 | |
| GSE43470 | TXNRD2 | 10587 | 4 | 7 | 32 | |
| GSE46452 | TXNRD2 | 10587 | 33 | 1 | 25 | |
| GSE47630 | TXNRD2 | 10587 | 8 | 5 | 27 | |
| GSE54993 | TXNRD2 | 10587 | 3 | 6 | 61 | |
| GSE54994 | TXNRD2 | 10587 | 12 | 7 | 34 | |
| GSE60625 | TXNRD2 | 10587 | 5 | 0 | 6 | |
| GSE74703 | TXNRD2 | 10587 | 4 | 5 | 27 | |
| GSE74704 | TXNRD2 | 10587 | 3 | 4 | 13 | |
| TCGA | TXNRD2 | 10587 | 27 | 17 | 52 |
Total number of gains: 109; Total number of losses: 66; Total Number of normals: 313.
Somatic mutations of TXNRD2:
Generating mutation plots.
Highly correlated genes for TXNRD2:
Showing top 20/300 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TXNRD2 | NACC1 | 0.705163 | 3 | 0 | 3 |
| TXNRD2 | GADD45GIP1 | 0.688303 | 3 | 0 | 3 |
| TXNRD2 | USP11 | 0.679496 | 3 | 0 | 3 |
| TXNRD2 | DAXX | 0.678179 | 4 | 0 | 3 |
| TXNRD2 | SF3B4 | 0.666607 | 4 | 0 | 3 |
| TXNRD2 | ZNF579 | 0.66491 | 3 | 0 | 3 |
| TXNRD2 | ZBTB39 | 0.65933 | 3 | 0 | 3 |
| TXNRD2 | ZNF628 | 0.653568 | 3 | 0 | 3 |
| TXNRD2 | GGT7 | 0.649408 | 3 | 0 | 3 |
| TXNRD2 | WIZ | 0.642544 | 5 | 0 | 4 |
| TXNRD2 | TMEM259 | 0.6413 | 3 | 0 | 3 |
| TXNRD2 | LSAMP-AS1 | 0.640039 | 3 | 0 | 3 |
| TXNRD2 | POLRMT | 0.637291 | 5 | 0 | 4 |
| TXNRD2 | C1orf35 | 0.63562 | 3 | 0 | 3 |
| TXNRD2 | SIN3B | 0.630988 | 5 | 0 | 4 |
| TXNRD2 | IFT122 | 0.630224 | 4 | 0 | 4 |
| TXNRD2 | PCYT1A | 0.629467 | 5 | 0 | 5 |
| TXNRD2 | TRAIP | 0.627802 | 3 | 0 | 3 |
| TXNRD2 | YDJC | 0.62465 | 6 | 0 | 5 |
| TXNRD2 | RAD23A | 0.622851 | 4 | 0 | 3 |
For details and further investigation, click here
