| Full name: FYVE, RhoGEF and PH domain containing 6 | Alias Symbol: ZFYVE24|FLJ11183 | ||
| Type: protein-coding gene | Cytoband: 12q22 | ||
| Entrez ID: 55785 | HGNC ID: HGNC:21740 | Ensembl Gene: ENSG00000180263 | OMIM ID: 613520 |
| Drug and gene relationship at DGIdb | |||
Expression of FGD6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FGD6 | 55785 | 226799_at | 0.7512 | 0.2108 | |
| GSE20347 | FGD6 | 55785 | 219901_at | 0.9275 | 0.0000 | |
| GSE23400 | FGD6 | 55785 | 219901_at | 0.5094 | 0.0000 | |
| GSE26886 | FGD6 | 55785 | 226799_at | 0.2738 | 0.2141 | |
| GSE29001 | FGD6 | 55785 | 219901_at | 0.8882 | 0.0525 | |
| GSE38129 | FGD6 | 55785 | 219901_at | 1.0210 | 0.0000 | |
| GSE45670 | FGD6 | 55785 | 219901_at | 0.5754 | 0.0279 | |
| GSE53622 | FGD6 | 55785 | 51 | 1.0355 | 0.0000 | |
| GSE53624 | FGD6 | 55785 | 51 | 0.9818 | 0.0000 | |
| GSE63941 | FGD6 | 55785 | 219901_at | 1.8804 | 0.0482 | |
| GSE77861 | FGD6 | 55785 | 226799_at | 0.2395 | 0.3039 | |
| GSE97050 | FGD6 | 55785 | A_32_P104478 | 0.3000 | 0.2027 | |
| SRP007169 | FGD6 | 55785 | RNAseq | 0.9886 | 0.0024 | |
| SRP008496 | FGD6 | 55785 | RNAseq | 1.4859 | 0.0000 | |
| SRP064894 | FGD6 | 55785 | RNAseq | 0.4534 | 0.1907 | |
| SRP133303 | FGD6 | 55785 | RNAseq | 0.7922 | 0.0001 | |
| SRP159526 | FGD6 | 55785 | RNAseq | 0.3362 | 0.2196 | |
| SRP193095 | FGD6 | 55785 | RNAseq | 0.9194 | 0.0000 | |
| SRP219564 | FGD6 | 55785 | RNAseq | 0.3200 | 0.4033 | |
| TCGA | FGD6 | 55785 | RNAseq | 0.5526 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by FGD6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FGD6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FGD6 | 55785 | 4 | 2 | 24 | |
| GSE20123 | FGD6 | 55785 | 4 | 2 | 24 | |
| GSE43470 | FGD6 | 55785 | 3 | 0 | 40 | |
| GSE46452 | FGD6 | 55785 | 9 | 1 | 49 | |
| GSE47630 | FGD6 | 55785 | 9 | 1 | 30 | |
| GSE54993 | FGD6 | 55785 | 0 | 5 | 65 | |
| GSE54994 | FGD6 | 55785 | 4 | 1 | 48 | |
| GSE60625 | FGD6 | 55785 | 0 | 0 | 11 | |
| GSE74703 | FGD6 | 55785 | 3 | 0 | 33 | |
| GSE74704 | FGD6 | 55785 | 1 | 2 | 17 | |
| TCGA | FGD6 | 55785 | 17 | 9 | 70 |
Total number of gains: 54; Total number of losses: 23; Total Number of normals: 411.
Somatic mutations of FGD6:
Generating mutation plots.
Highly correlated genes for FGD6:
Showing top 20/1157 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FGD6 | SLC30A7 | 0.770406 | 3 | 0 | 3 |
| FGD6 | TUBGCP3 | 0.756534 | 3 | 0 | 3 |
| FGD6 | ZNF707 | 0.748044 | 3 | 0 | 3 |
| FGD6 | ANLN | 0.715806 | 6 | 0 | 6 |
| FGD6 | PIBF1 | 0.703685 | 3 | 0 | 3 |
| FGD6 | STK17A | 0.698747 | 8 | 0 | 8 |
| FGD6 | RNF26 | 0.696755 | 3 | 0 | 3 |
| FGD6 | SPRED2 | 0.695345 | 4 | 0 | 3 |
| FGD6 | ZNF557 | 0.687913 | 3 | 0 | 3 |
| FGD6 | C17orf80 | 0.68621 | 3 | 0 | 3 |
| FGD6 | TMEM135 | 0.682853 | 5 | 0 | 4 |
| FGD6 | SRXN1 | 0.682737 | 3 | 0 | 3 |
| FGD6 | TMEM170A | 0.68237 | 4 | 0 | 3 |
| FGD6 | C18orf54 | 0.679462 | 4 | 0 | 3 |
| FGD6 | MMS22L | 0.676498 | 3 | 0 | 3 |
| FGD6 | THSD1 | 0.675825 | 3 | 0 | 3 |
| FGD6 | RNF138 | 0.674638 | 4 | 0 | 3 |
| FGD6 | KIF23 | 0.672032 | 10 | 0 | 10 |
| FGD6 | NECAP1 | 0.671513 | 5 | 0 | 3 |
| FGD6 | TIGD6 | 0.671081 | 3 | 0 | 3 |
For details and further investigation, click here
