| Full name: sulfiredoxin 1 | Alias Symbol: Npn3|SRX1|YKL086W|dJ850E9.2 | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 140809 | HGNC ID: HGNC:16132 | Ensembl Gene: ENSG00000271303 | OMIM ID: 617583 |
| Drug and gene relationship at DGIdb | |||
Expression of SRXN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRXN1 | 140809 | 225252_at | 0.3899 | 0.6233 | |
| GSE26886 | SRXN1 | 140809 | 225252_at | -0.2414 | 0.4658 | |
| GSE45670 | SRXN1 | 140809 | 225252_at | 0.5313 | 0.1562 | |
| GSE63941 | SRXN1 | 140809 | 225252_at | -0.6240 | 0.5596 | |
| GSE77861 | SRXN1 | 140809 | 225252_at | 0.7849 | 0.1050 | |
| GSE97050 | SRXN1 | 140809 | A_23_P320113 | 0.2124 | 0.5387 | |
| SRP007169 | SRXN1 | 140809 | RNAseq | -0.3689 | 0.4944 | |
| SRP008496 | SRXN1 | 140809 | RNAseq | 0.7911 | 0.1202 | |
| SRP064894 | SRXN1 | 140809 | RNAseq | -0.3322 | 0.1893 | |
| SRP133303 | SRXN1 | 140809 | RNAseq | 0.1837 | 0.4052 | |
| SRP159526 | SRXN1 | 140809 | RNAseq | 1.8536 | 0.0257 | |
| SRP193095 | SRXN1 | 140809 | RNAseq | 0.7254 | 0.0206 | |
| SRP219564 | SRXN1 | 140809 | RNAseq | 0.1796 | 0.7523 | |
| TCGA | SRXN1 | 140809 | RNAseq | 0.2496 | 0.0346 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SRXN1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SRXN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRXN1 | 140809 | 12 | 4 | 14 | |
| GSE20123 | SRXN1 | 140809 | 13 | 4 | 13 | |
| GSE43470 | SRXN1 | 140809 | 11 | 1 | 31 | |
| GSE46452 | SRXN1 | 140809 | 26 | 1 | 32 | |
| GSE47630 | SRXN1 | 140809 | 19 | 4 | 17 | |
| GSE54993 | SRXN1 | 140809 | 2 | 15 | 53 | |
| GSE54994 | SRXN1 | 140809 | 25 | 2 | 26 | |
| GSE60625 | SRXN1 | 140809 | 0 | 0 | 11 | |
| GSE74703 | SRXN1 | 140809 | 10 | 1 | 25 | |
| GSE74704 | SRXN1 | 140809 | 8 | 2 | 10 | |
| TCGA | SRXN1 | 140809 | 41 | 11 | 44 |
Total number of gains: 167; Total number of losses: 45; Total Number of normals: 276.
Somatic mutations of SRXN1:
Generating mutation plots.
Highly correlated genes for SRXN1:
Showing top 20/314 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRXN1 | ARV1 | 0.778471 | 3 | 0 | 3 |
| SRXN1 | NTPCR | 0.750988 | 3 | 0 | 3 |
| SRXN1 | BIRC6 | 0.747048 | 3 | 0 | 3 |
| SRXN1 | CDK5R1 | 0.728359 | 3 | 0 | 3 |
| SRXN1 | COG2 | 0.726012 | 3 | 0 | 3 |
| SRXN1 | KLHL13 | 0.721697 | 3 | 0 | 3 |
| SRXN1 | NDUFS1 | 0.71642 | 3 | 0 | 3 |
| SRXN1 | SLC7A11 | 0.713199 | 7 | 0 | 6 |
| SRXN1 | RELL2 | 0.7124 | 3 | 0 | 3 |
| SRXN1 | FAM169A | 0.708648 | 4 | 0 | 4 |
| SRXN1 | LRRC59 | 0.708094 | 3 | 0 | 3 |
| SRXN1 | SLC4A1AP | 0.706866 | 4 | 0 | 3 |
| SRXN1 | BAP1 | 0.706426 | 3 | 0 | 3 |
| SRXN1 | CPSF3 | 0.70463 | 4 | 0 | 4 |
| SRXN1 | TTC39C | 0.703171 | 3 | 0 | 3 |
| SRXN1 | SLC28A3 | 0.699227 | 3 | 0 | 3 |
| SRXN1 | ID1 | 0.699026 | 3 | 0 | 3 |
| SRXN1 | AHCTF1 | 0.69807 | 3 | 0 | 3 |
| SRXN1 | EID3 | 0.698067 | 5 | 0 | 5 |
| SRXN1 | PAK1 | 0.696592 | 3 | 0 | 3 |
For details and further investigation, click here
