| Full name: fibroblast growth factor 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q28.1 | ||
| Entrez ID: 2247 | HGNC ID: HGNC:3676 | Ensembl Gene: ENSG00000138685 | OMIM ID: 134920 |
| Drug and gene relationship at DGIdb | |||
FGF2 involved pathways:
Expression of FGF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FGF2 | 2247 | 204421_s_at | -0.5511 | 0.3997 | |
| GSE20347 | FGF2 | 2247 | 204421_s_at | 0.0526 | 0.5313 | |
| GSE23400 | FGF2 | 2247 | 204421_s_at | -0.0925 | 0.0435 | |
| GSE26886 | FGF2 | 2247 | 204421_s_at | 0.6471 | 0.0008 | |
| GSE29001 | FGF2 | 2247 | 204421_s_at | 0.2529 | 0.5169 | |
| GSE38129 | FGF2 | 2247 | 204421_s_at | -0.2670 | 0.1263 | |
| GSE45670 | FGF2 | 2247 | 204421_s_at | -0.2917 | 0.3345 | |
| GSE53622 | FGF2 | 2247 | 69580 | -1.5416 | 0.0000 | |
| GSE53624 | FGF2 | 2247 | 69580 | -0.9565 | 0.0000 | |
| GSE63941 | FGF2 | 2247 | 204421_s_at | -2.5845 | 0.0249 | |
| GSE77861 | FGF2 | 2247 | 204421_s_at | 0.0901 | 0.6158 | |
| GSE97050 | FGF2 | 2247 | A_33_P3419696 | -0.7187 | 0.2017 | |
| SRP007169 | FGF2 | 2247 | RNAseq | 1.6720 | 0.0491 | |
| SRP008496 | FGF2 | 2247 | RNAseq | 2.0987 | 0.0003 | |
| SRP064894 | FGF2 | 2247 | RNAseq | -0.1251 | 0.7097 | |
| SRP133303 | FGF2 | 2247 | RNAseq | -0.2473 | 0.5170 | |
| SRP159526 | FGF2 | 2247 | RNAseq | 0.9075 | 0.0473 | |
| SRP193095 | FGF2 | 2247 | RNAseq | 1.3458 | 0.0000 | |
| SRP219564 | FGF2 | 2247 | RNAseq | -0.2288 | 0.7510 | |
| TCGA | FGF2 | 2247 | RNAseq | -0.6305 | 0.0014 |
Upregulated datasets: 3; Downregulated datasets: 2.
Survival by FGF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FGF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FGF2 | 2247 | 0 | 13 | 17 | |
| GSE20123 | FGF2 | 2247 | 0 | 13 | 17 | |
| GSE43470 | FGF2 | 2247 | 0 | 13 | 30 | |
| GSE46452 | FGF2 | 2247 | 1 | 36 | 22 | |
| GSE47630 | FGF2 | 2247 | 0 | 22 | 18 | |
| GSE54993 | FGF2 | 2247 | 9 | 0 | 61 | |
| GSE54994 | FGF2 | 2247 | 1 | 10 | 42 | |
| GSE60625 | FGF2 | 2247 | 0 | 1 | 10 | |
| GSE74703 | FGF2 | 2247 | 0 | 11 | 25 | |
| GSE74704 | FGF2 | 2247 | 0 | 7 | 13 | |
| TCGA | FGF2 | 2247 | 8 | 35 | 53 |
Total number of gains: 19; Total number of losses: 161; Total Number of normals: 308.
Somatic mutations of FGF2:
Generating mutation plots.
Highly correlated genes for FGF2:
Showing top 20/951 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FGF2 | RBMX2 | 0.775761 | 3 | 0 | 3 |
| FGF2 | UBXN10 | 0.773444 | 3 | 0 | 3 |
| FGF2 | NPY1R | 0.760359 | 3 | 0 | 3 |
| FGF2 | ANGPTL1 | 0.753281 | 4 | 0 | 4 |
| FGF2 | CLEC3B | 0.750269 | 3 | 0 | 3 |
| FGF2 | TNFSF12 | 0.74626 | 3 | 0 | 3 |
| FGF2 | FAM124A | 0.736985 | 4 | 0 | 4 |
| FGF2 | RASSF3 | 0.73628 | 3 | 0 | 3 |
| FGF2 | C1QTNF7 | 0.73022 | 4 | 0 | 4 |
| FGF2 | ASPA | 0.724471 | 6 | 0 | 6 |
| FGF2 | HDAC9 | 0.720982 | 3 | 0 | 3 |
| FGF2 | RHOJ | 0.72036 | 4 | 0 | 4 |
| FGF2 | CNN1 | 0.719181 | 4 | 0 | 4 |
| FGF2 | LRRC75A | 0.717597 | 3 | 0 | 3 |
| FGF2 | TEAD2 | 0.717518 | 3 | 0 | 3 |
| FGF2 | ZNF449 | 0.715122 | 3 | 0 | 3 |
| FGF2 | PRKAR1A | 0.714792 | 3 | 0 | 3 |
| FGF2 | RHOU | 0.708021 | 4 | 0 | 4 |
| FGF2 | TCEAL5 | 0.707114 | 3 | 0 | 3 |
| FGF2 | KCNB1 | 0.706534 | 5 | 0 | 5 |
For details and further investigation, click here
