PRKAR1A

 

Full name: protein kinase cAMP-dependent type I regulatory subunit alpha Alias Symbol: CNC1
Type: protein-coding gene Cytoband: 17q24.2
Entrez ID: 5573 HGNC ID: HGNC:9388 Ensembl Gene: ENSG00000108946 OMIM ID: 188830
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 25/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PRKAR1A involved pathways:

KEGG pathway Description View
hsa04910Insulin signaling pathway

 

Expression of PRKAR1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKAR1A 5573 200603_at -0.2851 0.2278
GSE20347 PRKAR1A 5573 200603_at -0.3303 0.0011
GSE23400 PRKAR1A 5573 200603_at -0.2371 0.0089
GSE26886 PRKAR1A 5573 200603_at -0.4038 0.0231
GSE29001 PRKAR1A 5573 200603_at -0.1743 0.5830
GSE38129 PRKAR1A 5573 200603_at -0.3691 0.0000
GSE45670 PRKAR1A 5573 200603_at -0.2921 0.0024
GSE53622 PRKAR1A 5573 73135 -0.3564 0.0000
GSE53624 PRKAR1A 5573 73135 -0.2441 0.0000
GSE63941 PRKAR1A 5573 200603_at -1.0468 0.0014
GSE77861 PRKAR1A 5573 200603_at -0.3169 0.2215
GSE97050 PRKAR1A 5573 A_24_P245322 -0.7772 0.1224
SRP007169 PRKAR1A 5573 RNAseq -0.5029 0.1443
SRP008496 PRKAR1A 5573 RNAseq -0.3399 0.0685
SRP064894 PRKAR1A 5573 RNAseq -0.0865 0.6758
SRP133303 PRKAR1A 5573 RNAseq 0.0481 0.7201
SRP159526 PRKAR1A 5573 RNAseq -0.1311 0.7077
SRP193095 PRKAR1A 5573 RNAseq -0.1589 0.1821
SRP219564 PRKAR1A 5573 RNAseq -0.1247 0.5565
TCGA PRKAR1A 5573 RNAseq -0.0750 0.0515

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by PRKAR1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKAR1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKAR1A 5573 3 2 25
GSE20123 PRKAR1A 5573 3 2 25
GSE43470 PRKAR1A 5573 5 0 38
GSE46452 PRKAR1A 5573 31 1 27
GSE47630 PRKAR1A 5573 7 1 32
GSE54993 PRKAR1A 5573 2 5 63
GSE54994 PRKAR1A 5573 9 4 40
GSE60625 PRKAR1A 5573 4 3 4
GSE74703 PRKAR1A 5573 5 0 31
GSE74704 PRKAR1A 5573 3 1 16
TCGA PRKAR1A 5573 28 9 59

Total number of gains: 100; Total number of losses: 28; Total Number of normals: 360.  

 

Somatic mutations of PRKAR1A:

 

Generating mutation plots.

 

Highly correlated genes for PRKAR1A:

 

Showing top 20/980 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKAR1AANKRD370.804622303
PRKAR1AHNRNPH10.727514303
PRKAR1AZNF8790.726335303
PRKAR1ATAF70.723904303
PRKAR1ASLU70.72323403
PRKAR1AFGF20.714792303
PRKAR1ARGMB0.708842303
PRKAR1ATYW30.708166303
PRKAR1AANGPTL40.699569303
PRKAR1APOLR2B0.697427303
PRKAR1ATMX30.685181504
PRKAR1ASEL1L0.68264303
PRKAR1APPP4R10.675803404
PRKAR1AFNIP20.675455403
PRKAR1ANBN0.670978303
PRKAR1ACNST0.66893303
PRKAR1ANTN40.66888403
PRKAR1AICA1L0.666007404
PRKAR1ATMOD20.664666606
PRKAR1AARSK0.664318303

For details and further investigation, click here