| Full name: fms related tyrosine kinase 3 ligand | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 2323 | HGNC ID: HGNC:3766 | Ensembl Gene: ENSG00000090554 | OMIM ID: 600007 |
| Drug and gene relationship at DGIdb | |||
FLT3LG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer |
Expression of FLT3LG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FLT3LG | 2323 | 206980_s_at | -0.0465 | 0.9414 | |
| GSE20347 | FLT3LG | 2323 | 206980_s_at | -0.1352 | 0.0198 | |
| GSE23400 | FLT3LG | 2323 | 206980_s_at | -0.0980 | 0.0027 | |
| GSE26886 | FLT3LG | 2323 | 206980_s_at | 0.4173 | 0.0068 | |
| GSE29001 | FLT3LG | 2323 | 210607_at | 0.0855 | 0.7052 | |
| GSE38129 | FLT3LG | 2323 | 206980_s_at | -0.1445 | 0.0299 | |
| GSE45670 | FLT3LG | 2323 | 206980_s_at | 0.0527 | 0.6399 | |
| GSE63941 | FLT3LG | 2323 | 206980_s_at | 0.1176 | 0.7515 | |
| GSE77861 | FLT3LG | 2323 | 210607_at | -0.1233 | 0.2177 | |
| GSE97050 | FLT3LG | 2323 | A_23_P78742 | -0.1478 | 0.6594 | |
| SRP064894 | FLT3LG | 2323 | RNAseq | 0.1890 | 0.5973 | |
| SRP133303 | FLT3LG | 2323 | RNAseq | -0.5073 | 0.0431 | |
| SRP159526 | FLT3LG | 2323 | RNAseq | -0.2944 | 0.3427 | |
| SRP193095 | FLT3LG | 2323 | RNAseq | 0.1669 | 0.3389 | |
| SRP219564 | FLT3LG | 2323 | RNAseq | 0.2987 | 0.4630 | |
| TCGA | FLT3LG | 2323 | RNAseq | 0.1800 | 0.1107 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FLT3LG expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of FLT3LG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FLT3LG | 2323 | 4 | 4 | 22 | |
| GSE20123 | FLT3LG | 2323 | 4 | 3 | 23 | |
| GSE43470 | FLT3LG | 2323 | 4 | 11 | 28 | |
| GSE46452 | FLT3LG | 2323 | 45 | 1 | 13 | |
| GSE47630 | FLT3LG | 2323 | 10 | 6 | 24 | |
| GSE54993 | FLT3LG | 2323 | 17 | 4 | 49 | |
| GSE54994 | FLT3LG | 2323 | 4 | 14 | 35 | |
| GSE60625 | FLT3LG | 2323 | 9 | 0 | 2 | |
| GSE74703 | FLT3LG | 2323 | 4 | 7 | 25 | |
| GSE74704 | FLT3LG | 2323 | 4 | 1 | 15 | |
| TCGA | FLT3LG | 2323 | 14 | 19 | 63 |
Total number of gains: 119; Total number of losses: 70; Total Number of normals: 299.
Somatic mutations of FLT3LG:
Generating mutation plots.
Highly correlated genes for FLT3LG:
Showing top 20/174 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FLT3LG | EEPD1 | 0.812518 | 3 | 0 | 3 |
| FLT3LG | MRPL41 | 0.772746 | 3 | 0 | 3 |
| FLT3LG | RAB37 | 0.770748 | 3 | 0 | 3 |
| FLT3LG | ADH1A | 0.762579 | 3 | 0 | 3 |
| FLT3LG | GDF9 | 0.747583 | 3 | 0 | 3 |
| FLT3LG | B4GALNT4 | 0.735213 | 3 | 0 | 3 |
| FLT3LG | ARHGAP24 | 0.726077 | 3 | 0 | 3 |
| FLT3LG | TRIM22 | 0.723975 | 3 | 0 | 3 |
| FLT3LG | UAP1L1 | 0.719267 | 3 | 0 | 3 |
| FLT3LG | CSF1R | 0.718883 | 4 | 0 | 3 |
| FLT3LG | TNFSF8 | 0.716928 | 3 | 0 | 3 |
| FLT3LG | CDK18 | 0.713503 | 3 | 0 | 3 |
| FLT3LG | ZNF449 | 0.711176 | 3 | 0 | 3 |
| FLT3LG | C16orf86 | 0.697146 | 3 | 0 | 3 |
| FLT3LG | C15orf61 | 0.696786 | 3 | 0 | 3 |
| FLT3LG | FCRL4 | 0.694568 | 3 | 0 | 3 |
| FLT3LG | FHL3 | 0.694208 | 3 | 0 | 3 |
| FLT3LG | PCGF5 | 0.689605 | 3 | 0 | 3 |
| FLT3LG | ZSCAN21 | 0.6865 | 3 | 0 | 3 |
| FLT3LG | PHLDB1 | 0.684291 | 3 | 0 | 3 |
For details and further investigation, click here
