| Full name: cyclin dependent kinase 18 | Alias Symbol: PCTAIRE3 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 5129 | HGNC ID: HGNC:8751 | Ensembl Gene: ENSG00000117266 | OMIM ID: 169190 |
| Drug and gene relationship at DGIdb | |||
Expression of CDK18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDK18 | 5129 | 214797_s_at | 1.0483 | 0.0316 | |
| GSE20347 | CDK18 | 5129 | 214797_s_at | 0.4459 | 0.0009 | |
| GSE23400 | CDK18 | 5129 | 214797_s_at | 0.2820 | 0.0001 | |
| GSE26886 | CDK18 | 5129 | 214797_s_at | 0.7292 | 0.0001 | |
| GSE29001 | CDK18 | 5129 | 214797_s_at | 0.1006 | 0.5605 | |
| GSE38129 | CDK18 | 5129 | 214797_s_at | 0.4331 | 0.0012 | |
| GSE45670 | CDK18 | 5129 | 214797_s_at | 0.1870 | 0.3049 | |
| GSE53622 | CDK18 | 5129 | 70496 | 0.9981 | 0.0000 | |
| GSE53624 | CDK18 | 5129 | 70496 | 0.6430 | 0.0000 | |
| GSE63941 | CDK18 | 5129 | 214797_s_at | 0.9230 | 0.0218 | |
| GSE77861 | CDK18 | 5129 | 214797_s_at | 0.0600 | 0.7048 | |
| GSE97050 | CDK18 | 5129 | A_23_P201863 | 0.6271 | 0.2081 | |
| SRP007169 | CDK18 | 5129 | RNAseq | 2.3068 | 0.0021 | |
| SRP064894 | CDK18 | 5129 | RNAseq | 1.1068 | 0.0000 | |
| SRP133303 | CDK18 | 5129 | RNAseq | 1.1211 | 0.0000 | |
| SRP159526 | CDK18 | 5129 | RNAseq | 0.9339 | 0.0189 | |
| SRP193095 | CDK18 | 5129 | RNAseq | 1.2163 | 0.0000 | |
| SRP219564 | CDK18 | 5129 | RNAseq | 1.1449 | 0.0003 | |
| TCGA | CDK18 | 5129 | RNAseq | -0.1963 | 0.0914 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by CDK18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDK18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDK18 | 5129 | 11 | 0 | 19 | |
| GSE20123 | CDK18 | 5129 | 11 | 0 | 19 | |
| GSE43470 | CDK18 | 5129 | 7 | 0 | 36 | |
| GSE46452 | CDK18 | 5129 | 3 | 1 | 55 | |
| GSE47630 | CDK18 | 5129 | 14 | 0 | 26 | |
| GSE54993 | CDK18 | 5129 | 0 | 6 | 64 | |
| GSE54994 | CDK18 | 5129 | 15 | 0 | 38 | |
| GSE60625 | CDK18 | 5129 | 0 | 0 | 11 | |
| GSE74703 | CDK18 | 5129 | 7 | 0 | 29 | |
| GSE74704 | CDK18 | 5129 | 5 | 0 | 15 | |
| TCGA | CDK18 | 5129 | 43 | 5 | 48 |
Total number of gains: 116; Total number of losses: 12; Total Number of normals: 360.
Somatic mutations of CDK18:
Generating mutation plots.
Highly correlated genes for CDK18:
Showing top 20/1230 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDK18 | RIOK1 | 0.80012 | 3 | 0 | 3 |
| CDK18 | ZNF628 | 0.797617 | 3 | 0 | 3 |
| CDK18 | NACC1 | 0.787679 | 3 | 0 | 3 |
| CDK18 | CASK | 0.771378 | 3 | 0 | 3 |
| CDK18 | SSBP4 | 0.769253 | 3 | 0 | 3 |
| CDK18 | NOTCH3 | 0.761077 | 3 | 0 | 3 |
| CDK18 | BHLHE41 | 0.760375 | 3 | 0 | 3 |
| CDK18 | ROMO1 | 0.755032 | 3 | 0 | 3 |
| CDK18 | QSOX2 | 0.752325 | 3 | 0 | 3 |
| CDK18 | ZC3HC1 | 0.743927 | 3 | 0 | 3 |
| CDK18 | GAS2L1 | 0.735426 | 3 | 0 | 3 |
| CDK18 | ALKBH6 | 0.728754 | 3 | 0 | 3 |
| CDK18 | SLC25A1 | 0.726224 | 3 | 0 | 3 |
| CDK18 | SERPINF2 | 0.720131 | 4 | 0 | 4 |
| CDK18 | ANKRD54 | 0.718426 | 3 | 0 | 3 |
| CDK18 | SCAND1 | 0.717784 | 3 | 0 | 3 |
| CDK18 | FLT3LG | 0.713503 | 3 | 0 | 3 |
| CDK18 | FZD6 | 0.713401 | 4 | 0 | 3 |
| CDK18 | MRPL55 | 0.711498 | 4 | 0 | 3 |
| CDK18 | LRRC58 | 0.708039 | 3 | 0 | 3 |
For details and further investigation, click here
