| Full name: mitochondrial ribosomal protein L41 | Alias Symbol: MRP-L27|RPML27|BMRP|PIG3|MRPL27 | ||
| Type: protein-coding gene | Cytoband: 9q34.3 | ||
| Entrez ID: 64975 | HGNC ID: HGNC:14492 | Ensembl Gene: ENSG00000182154 | OMIM ID: 611846 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPL41:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL41 | 64975 | 227186_s_at | -0.0458 | 0.8865 | |
| GSE20347 | MRPL41 | 64975 | 221936_x_at | -0.0391 | 0.6375 | |
| GSE23400 | MRPL41 | 64975 | 221936_x_at | -0.1525 | 0.0000 | |
| GSE26886 | MRPL41 | 64975 | 227186_s_at | 0.9219 | 0.0007 | |
| GSE29001 | MRPL41 | 64975 | 221936_x_at | -0.0435 | 0.7713 | |
| GSE38129 | MRPL41 | 64975 | 221936_x_at | -0.0928 | 0.2507 | |
| GSE45670 | MRPL41 | 64975 | 227186_s_at | 0.1229 | 0.3803 | |
| GSE53622 | MRPL41 | 64975 | 23818 | 0.0747 | 0.3982 | |
| GSE53624 | MRPL41 | 64975 | 23818 | 0.6059 | 0.0000 | |
| GSE63941 | MRPL41 | 64975 | 227186_s_at | 0.8268 | 0.0746 | |
| GSE77861 | MRPL41 | 64975 | 227186_s_at | 0.3309 | 0.0607 | |
| GSE97050 | MRPL41 | 64975 | A_32_P115130 | 0.1486 | 0.4892 | |
| SRP007169 | MRPL41 | 64975 | RNAseq | -0.2063 | 0.5617 | |
| SRP008496 | MRPL41 | 64975 | RNAseq | -0.1470 | 0.5698 | |
| SRP064894 | MRPL41 | 64975 | RNAseq | 0.8615 | 0.0431 | |
| SRP133303 | MRPL41 | 64975 | RNAseq | 0.4047 | 0.0658 | |
| SRP159526 | MRPL41 | 64975 | RNAseq | 0.4603 | 0.0237 | |
| SRP193095 | MRPL41 | 64975 | RNAseq | 0.0293 | 0.8423 | |
| SRP219564 | MRPL41 | 64975 | RNAseq | -0.0095 | 0.9752 | |
| TCGA | MRPL41 | 64975 | RNAseq | -0.0674 | 0.3902 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPL41 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL41:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL41 | 64975 | 4 | 7 | 19 | |
| GSE20123 | MRPL41 | 64975 | 4 | 7 | 19 | |
| GSE43470 | MRPL41 | 64975 | 3 | 7 | 33 | |
| GSE46452 | MRPL41 | 64975 | 6 | 13 | 40 | |
| GSE47630 | MRPL41 | 64975 | 6 | 15 | 19 | |
| GSE54993 | MRPL41 | 64975 | 3 | 3 | 64 | |
| GSE54994 | MRPL41 | 64975 | 19 | 3 | 31 | |
| GSE60625 | MRPL41 | 64975 | 0 | 0 | 11 | |
| GSE74703 | MRPL41 | 64975 | 3 | 5 | 28 | |
| GSE74704 | MRPL41 | 64975 | 2 | 5 | 13 | |
| TCGA | MRPL41 | 64975 | 29 | 23 | 44 |
Total number of gains: 79; Total number of losses: 88; Total Number of normals: 321.
Somatic mutations of MRPL41:
Generating mutation plots.
Highly correlated genes for MRPL41:
Showing top 20/663 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL41 | FLT3LG | 0.772746 | 3 | 0 | 3 |
| MRPL41 | DPP7 | 0.771423 | 3 | 0 | 3 |
| MRPL41 | ACVRL1 | 0.765197 | 3 | 0 | 3 |
| MRPL41 | C3orf33 | 0.761514 | 3 | 0 | 3 |
| MRPL41 | LAGE3 | 0.759722 | 3 | 0 | 3 |
| MRPL41 | ARR3 | 0.748415 | 3 | 0 | 3 |
| MRPL41 | ATF7 | 0.737373 | 3 | 0 | 3 |
| MRPL41 | MAGEF1 | 0.734201 | 3 | 0 | 3 |
| MRPL41 | C12orf65 | 0.732809 | 3 | 0 | 3 |
| MRPL41 | ZNF287 | 0.732697 | 3 | 0 | 3 |
| MRPL41 | PRR14 | 0.731512 | 3 | 0 | 3 |
| MRPL41 | EBF2 | 0.721729 | 3 | 0 | 3 |
| MRPL41 | GDAP1 | 0.720899 | 3 | 0 | 3 |
| MRPL41 | CEP85 | 0.717485 | 3 | 0 | 3 |
| MRPL41 | ZNF354A | 0.716984 | 3 | 0 | 3 |
| MRPL41 | MOB3C | 0.71586 | 3 | 0 | 3 |
| MRPL41 | CST8 | 0.710409 | 3 | 0 | 3 |
| MRPL41 | TPPP | 0.709854 | 3 | 0 | 3 |
| MRPL41 | NMNAT2 | 0.709028 | 4 | 0 | 4 |
| MRPL41 | BCORL1 | 0.70666 | 3 | 0 | 3 |
For details and further investigation, click here
