| Full name: four and a half LIM domains 3 | Alias Symbol: SLIM2 | ||
| Type: protein-coding gene | Cytoband: 1p34.3 | ||
| Entrez ID: 2275 | HGNC ID: HGNC:3704 | Ensembl Gene: ENSG00000183386 | OMIM ID: 602790 |
| Drug and gene relationship at DGIdb | |||
Expression of FHL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FHL3 | 2275 | 218818_at | 0.3617 | 0.1372 | |
| GSE20347 | FHL3 | 2275 | 218818_at | 0.1449 | 0.1331 | |
| GSE23400 | FHL3 | 2275 | 218818_at | 0.0620 | 0.1595 | |
| GSE26886 | FHL3 | 2275 | 218818_at | 0.5799 | 0.0000 | |
| GSE29001 | FHL3 | 2275 | 218818_at | 0.1417 | 0.5286 | |
| GSE38129 | FHL3 | 2275 | 218818_at | 0.1414 | 0.0915 | |
| GSE45670 | FHL3 | 2275 | 218818_at | 0.1092 | 0.3868 | |
| GSE53622 | FHL3 | 2275 | 148260 | 0.3029 | 0.0001 | |
| GSE53624 | FHL3 | 2275 | 148260 | -0.0192 | 0.8537 | |
| GSE63941 | FHL3 | 2275 | 218818_at | -0.4607 | 0.0703 | |
| GSE77861 | FHL3 | 2275 | 218818_at | 0.0041 | 0.9804 | |
| GSE97050 | FHL3 | 2275 | A_23_P114839 | 0.3894 | 0.1471 | |
| SRP007169 | FHL3 | 2275 | RNAseq | 1.3005 | 0.0456 | |
| SRP064894 | FHL3 | 2275 | RNAseq | 1.0928 | 0.0018 | |
| SRP133303 | FHL3 | 2275 | RNAseq | 0.3736 | 0.1136 | |
| SRP159526 | FHL3 | 2275 | RNAseq | 0.3442 | 0.4501 | |
| SRP193095 | FHL3 | 2275 | RNAseq | 0.8381 | 0.0000 | |
| SRP219564 | FHL3 | 2275 | RNAseq | 0.5421 | 0.1920 | |
| TCGA | FHL3 | 2275 | RNAseq | 0.1465 | 0.0750 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by FHL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FHL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FHL3 | 2275 | 2 | 4 | 24 | |
| GSE20123 | FHL3 | 2275 | 2 | 3 | 25 | |
| GSE43470 | FHL3 | 2275 | 7 | 3 | 33 | |
| GSE46452 | FHL3 | 2275 | 4 | 1 | 54 | |
| GSE47630 | FHL3 | 2275 | 8 | 3 | 29 | |
| GSE54993 | FHL3 | 2275 | 0 | 1 | 69 | |
| GSE54994 | FHL3 | 2275 | 12 | 2 | 39 | |
| GSE60625 | FHL3 | 2275 | 0 | 0 | 11 | |
| GSE74703 | FHL3 | 2275 | 6 | 2 | 28 | |
| GSE74704 | FHL3 | 2275 | 1 | 0 | 19 | |
| TCGA | FHL3 | 2275 | 12 | 17 | 67 |
Total number of gains: 54; Total number of losses: 36; Total Number of normals: 398.
Somatic mutations of FHL3:
Generating mutation plots.
Highly correlated genes for FHL3:
Showing top 20/920 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FHL3 | SAFB2 | 0.841471 | 3 | 0 | 3 |
| FHL3 | GMNN | 0.795521 | 3 | 0 | 3 |
| FHL3 | GPNMB | 0.793494 | 3 | 0 | 3 |
| FHL3 | MCM6 | 0.78923 | 3 | 0 | 3 |
| FHL3 | BRI3 | 0.788235 | 3 | 0 | 3 |
| FHL3 | MRPL47 | 0.786163 | 3 | 0 | 3 |
| FHL3 | NXT1 | 0.781767 | 3 | 0 | 3 |
| FHL3 | BOLA3 | 0.778494 | 3 | 0 | 3 |
| FHL3 | MEF2D | 0.775084 | 3 | 0 | 3 |
| FHL3 | DZIP1L | 0.770803 | 4 | 0 | 4 |
| FHL3 | ACD | 0.768015 | 4 | 0 | 4 |
| FHL3 | CEP78 | 0.766462 | 3 | 0 | 3 |
| FHL3 | DNMT1 | 0.763232 | 3 | 0 | 3 |
| FHL3 | CACYBP | 0.762044 | 3 | 0 | 3 |
| FHL3 | GAS2L1 | 0.761366 | 3 | 0 | 3 |
| FHL3 | FKBP11 | 0.760619 | 3 | 0 | 3 |
| FHL3 | MRPS23 | 0.758211 | 3 | 0 | 3 |
| FHL3 | NUP43 | 0.755362 | 3 | 0 | 3 |
| FHL3 | LIMD2 | 0.751914 | 3 | 0 | 3 |
| FHL3 | DHDH | 0.749578 | 3 | 0 | 3 |
For details and further investigation, click here
