CSF1R

 

Full name: colony stimulating factor 1 receptor Alias Symbol: C-FMS|CSFR|CD115
Type: protein-coding gene Cytoband: 5q32
Entrez ID: 1436 HGNC ID: HGNC:2433 Ensembl Gene: ENSG00000182578 OMIM ID: 164770
Drug and gene relationship at DGIdb

 

CSF1R involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04380Osteoclast differentiation
hsa05200Pathways in cancer

 

Expression of CSF1R:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CSF1R 1436 203104_at 0.0870 0.9444
GSE20347 CSF1R 1436 203104_at 0.0228 0.8958
GSE23400 CSF1R 1436 203104_at 0.0794 0.4040
GSE26886 CSF1R 1436 203104_at -0.4078 0.0809
GSE29001 CSF1R 1436 203104_at 0.2381 0.2763
GSE38129 CSF1R 1436 203104_at -0.0913 0.6247
GSE45670 CSF1R 1436 203104_at -0.3524 0.0444
GSE53622 CSF1R 1436 21512 -0.1831 0.2191
GSE53624 CSF1R 1436 51887 0.0438 0.7087
GSE63941 CSF1R 1436 203104_at -0.0118 0.9624
GSE77861 CSF1R 1436 203104_at -0.0468 0.8564
GSE97050 CSF1R 1436 A_23_P110791 0.3392 0.4399
SRP007169 CSF1R 1436 RNAseq 1.1723 0.0846
SRP008496 CSF1R 1436 RNAseq 0.9119 0.0241
SRP064894 CSF1R 1436 RNAseq 0.6683 0.0496
SRP133303 CSF1R 1436 RNAseq 0.0896 0.7896
SRP159526 CSF1R 1436 RNAseq -0.2914 0.6309
SRP193095 CSF1R 1436 RNAseq 0.0207 0.8995
SRP219564 CSF1R 1436 RNAseq 0.8382 0.1790
TCGA CSF1R 1436 RNAseq -0.3170 0.0082

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CSF1R expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CSF1R:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CSF1R 1436 1 12 17
GSE20123 CSF1R 1436 1 12 17
GSE43470 CSF1R 1436 1 10 32
GSE46452 CSF1R 1436 0 27 32
GSE47630 CSF1R 1436 0 20 20
GSE54993 CSF1R 1436 9 1 60
GSE54994 CSF1R 1436 2 15 36
GSE60625 CSF1R 1436 0 0 11
GSE74703 CSF1R 1436 1 7 28
GSE74704 CSF1R 1436 1 7 12
TCGA CSF1R 1436 5 38 53

Total number of gains: 21; Total number of losses: 149; Total Number of normals: 318.  

 

Somatic mutations of CSF1R:

 

Generating mutation plots.

 

Highly correlated genes for CSF1R:

 

Showing top 20/510 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CSF1RAIF10.79701712012
CSF1RMPEG10.783145707
CSF1RMS4A4A0.7753741009
CSF1RMS4A6A0.76912312011
CSF1RCD530.76027310010
CSF1RTYROBP0.75924812012
CSF1RC19orf380.755302303
CSF1RC1QA0.75130512011
CSF1RHGF0.750085404
CSF1RHVCN10.748909606
CSF1RFLI10.740861808
CSF1RC1QC0.734916808
CSF1RGIMAP50.728094404
CSF1RFLT3LG0.718883403
CSF1RDOK10.717995504
CSF1RLAPTM50.71512613012
CSF1RGIMAP10.714298807
CSF1RCYBB0.71327111011
CSF1RGIMAP40.71258911011
CSF1RGPR340.712032807

For details and further investigation, click here