| Full name: flavin containing dimethylaniline monoxygenase 3 | Alias Symbol: FMOII | ||
| Type: protein-coding gene | Cytoband: 1q24.3 | ||
| Entrez ID: 2328 | HGNC ID: HGNC:3771 | Ensembl Gene: ENSG00000007933 | OMIM ID: 136132 |
| Drug and gene relationship at DGIdb | |||
Expression of FMO3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FMO3 | 2328 | 206496_at | -1.1947 | 0.1168 | |
| GSE20347 | FMO3 | 2328 | 206496_at | 0.2720 | 0.6143 | |
| GSE23400 | FMO3 | 2328 | 206496_at | -0.0451 | 0.3736 | |
| GSE26886 | FMO3 | 2328 | 206496_at | 0.9409 | 0.1275 | |
| GSE29001 | FMO3 | 2328 | 206496_at | -0.4744 | 0.0167 | |
| GSE38129 | FMO3 | 2328 | 206496_at | 0.1567 | 0.7278 | |
| GSE45670 | FMO3 | 2328 | 206496_at | -0.5998 | 0.1144 | |
| GSE53622 | FMO3 | 2328 | 28686 | -0.6587 | 0.0004 | |
| GSE53624 | FMO3 | 2328 | 28686 | -0.7029 | 0.0000 | |
| GSE63941 | FMO3 | 2328 | 206496_at | -1.6626 | 0.0021 | |
| GSE77861 | FMO3 | 2328 | 206496_at | 0.0092 | 0.9372 | |
| GSE97050 | FMO3 | 2328 | A_23_P155596 | -0.1698 | 0.6835 | |
| SRP007169 | FMO3 | 2328 | RNAseq | -0.6339 | 0.4015 | |
| SRP064894 | FMO3 | 2328 | RNAseq | -1.1079 | 0.0001 | |
| SRP133303 | FMO3 | 2328 | RNAseq | -0.2686 | 0.5222 | |
| SRP159526 | FMO3 | 2328 | RNAseq | -0.3943 | 0.6578 | |
| SRP193095 | FMO3 | 2328 | RNAseq | -0.0843 | 0.7480 | |
| SRP219564 | FMO3 | 2328 | RNAseq | 0.3763 | 0.6550 | |
| TCGA | FMO3 | 2328 | RNAseq | -0.0390 | 0.8620 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by FMO3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FMO3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FMO3 | 2328 | 12 | 1 | 17 | |
| GSE20123 | FMO3 | 2328 | 12 | 1 | 17 | |
| GSE43470 | FMO3 | 2328 | 7 | 2 | 34 | |
| GSE46452 | FMO3 | 2328 | 3 | 1 | 55 | |
| GSE47630 | FMO3 | 2328 | 14 | 0 | 26 | |
| GSE54993 | FMO3 | 2328 | 0 | 6 | 64 | |
| GSE54994 | FMO3 | 2328 | 16 | 0 | 37 | |
| GSE60625 | FMO3 | 2328 | 0 | 0 | 11 | |
| GSE74703 | FMO3 | 2328 | 7 | 2 | 27 | |
| GSE74704 | FMO3 | 2328 | 6 | 0 | 14 | |
| TCGA | FMO3 | 2328 | 43 | 3 | 50 |
Total number of gains: 120; Total number of losses: 16; Total Number of normals: 352.
Somatic mutations of FMO3:
Generating mutation plots.
Highly correlated genes for FMO3:
Showing top 20/405 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FMO3 | EIF4ENIF1 | 0.792518 | 3 | 0 | 3 |
| FMO3 | TRAF6 | 0.78609 | 3 | 0 | 3 |
| FMO3 | STOML1 | 0.75003 | 3 | 0 | 3 |
| FMO3 | VAMP7 | 0.747771 | 3 | 0 | 3 |
| FMO3 | SNX25 | 0.745273 | 3 | 0 | 3 |
| FMO3 | SLC25A3 | 0.718328 | 3 | 0 | 3 |
| FMO3 | FMO4 | 0.707704 | 3 | 0 | 3 |
| FMO3 | FBXO8 | 0.696797 | 4 | 0 | 3 |
| FMO3 | KLRB1 | 0.688314 | 6 | 0 | 6 |
| FMO3 | OCM2 | 0.685808 | 3 | 0 | 3 |
| FMO3 | SMPD1 | 0.682324 | 4 | 0 | 3 |
| FMO3 | PIGR | 0.682182 | 3 | 0 | 3 |
| FMO3 | BHLHE22 | 0.68139 | 4 | 0 | 3 |
| FMO3 | SNX12 | 0.6808 | 3 | 0 | 3 |
| FMO3 | RHOJ | 0.679978 | 3 | 0 | 3 |
| FMO3 | C11orf96 | 0.67867 | 3 | 0 | 3 |
| FMO3 | RNF185 | 0.675281 | 3 | 0 | 3 |
| FMO3 | FRS2 | 0.674337 | 3 | 0 | 3 |
| FMO3 | XPC | 0.661117 | 4 | 0 | 3 |
| FMO3 | IGBP1 | 0.658604 | 5 | 0 | 4 |
For details and further investigation, click here
