| Full name: killer cell lectin like receptor B1 | Alias Symbol: CD161|NKR-P1|NKR-P1A|hNKR-P1A|CLEC5B | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 3820 | HGNC ID: HGNC:6373 | Ensembl Gene: ENSG00000111796 | OMIM ID: 602890 |
| Drug and gene relationship at DGIdb | |||
Expression of KLRB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLRB1 | 3820 | 214470_at | -0.4019 | 0.7875 | |
| GSE20347 | KLRB1 | 3820 | 214470_at | -0.7115 | 0.0004 | |
| GSE23400 | KLRB1 | 3820 | 214470_at | -0.1254 | 0.0196 | |
| GSE26886 | KLRB1 | 3820 | 214470_at | -1.1037 | 0.0054 | |
| GSE29001 | KLRB1 | 3820 | 214470_at | -0.5173 | 0.0014 | |
| GSE38129 | KLRB1 | 3820 | 214470_at | -0.7264 | 0.0007 | |
| GSE45670 | KLRB1 | 3820 | 214470_at | -0.8979 | 0.0029 | |
| GSE53622 | KLRB1 | 3820 | 33903 | -1.3147 | 0.0000 | |
| GSE53624 | KLRB1 | 3820 | 33903 | -1.7916 | 0.0000 | |
| GSE63941 | KLRB1 | 3820 | 214470_at | -0.0223 | 0.9083 | |
| GSE77861 | KLRB1 | 3820 | 214470_at | -0.3677 | 0.1309 | |
| GSE97050 | KLRB1 | 3820 | A_23_P99275 | 0.4714 | 0.3082 | |
| SRP064894 | KLRB1 | 3820 | RNAseq | -0.7206 | 0.0938 | |
| SRP133303 | KLRB1 | 3820 | RNAseq | -0.8628 | 0.0001 | |
| SRP159526 | KLRB1 | 3820 | RNAseq | -1.7359 | 0.0510 | |
| SRP193095 | KLRB1 | 3820 | RNAseq | -1.1229 | 0.0002 | |
| SRP219564 | KLRB1 | 3820 | RNAseq | -1.0274 | 0.1242 | |
| TCGA | KLRB1 | 3820 | RNAseq | -0.8962 | 0.0326 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by KLRB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLRB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLRB1 | 3820 | 6 | 3 | 21 | |
| GSE20123 | KLRB1 | 3820 | 6 | 3 | 21 | |
| GSE43470 | KLRB1 | 3820 | 8 | 3 | 32 | |
| GSE46452 | KLRB1 | 3820 | 10 | 1 | 48 | |
| GSE47630 | KLRB1 | 3820 | 14 | 2 | 24 | |
| GSE54993 | KLRB1 | 3820 | 1 | 10 | 59 | |
| GSE54994 | KLRB1 | 3820 | 9 | 2 | 42 | |
| GSE60625 | KLRB1 | 3820 | 0 | 1 | 10 | |
| GSE74703 | KLRB1 | 3820 | 8 | 2 | 26 | |
| GSE74704 | KLRB1 | 3820 | 4 | 2 | 14 | |
| TCGA | KLRB1 | 3820 | 39 | 6 | 51 |
Total number of gains: 105; Total number of losses: 35; Total Number of normals: 348.
Somatic mutations of KLRB1:
Generating mutation plots.
Highly correlated genes for KLRB1:
Showing top 20/813 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLRB1 | BTLA | 0.810565 | 5 | 0 | 5 |
| KLRB1 | C16orf54 | 0.758118 | 6 | 0 | 6 |
| KLRB1 | RAB39B | 0.753992 | 4 | 0 | 4 |
| KLRB1 | LINC00892 | 0.744116 | 4 | 0 | 4 |
| KLRB1 | GAPT | 0.743218 | 6 | 0 | 6 |
| KLRB1 | GIMAP7 | 0.740504 | 7 | 0 | 6 |
| KLRB1 | THEMIS | 0.735643 | 6 | 0 | 6 |
| KLRB1 | CD48 | 0.732978 | 11 | 0 | 11 |
| KLRB1 | ARHGAP15 | 0.728949 | 4 | 0 | 4 |
| KLRB1 | ANKRD44 | 0.727804 | 7 | 0 | 7 |
| KLRB1 | TAGAP | 0.725553 | 6 | 0 | 6 |
| KLRB1 | SNX12 | 0.721052 | 3 | 0 | 3 |
| KLRB1 | GIMAP5 | 0.718517 | 4 | 0 | 4 |
| KLRB1 | LINC01215 | 0.714422 | 5 | 0 | 5 |
| KLRB1 | CCR4 | 0.712194 | 4 | 0 | 3 |
| KLRB1 | SPOCK2 | 0.711261 | 7 | 0 | 6 |
| KLRB1 | P2RY8 | 0.707558 | 4 | 0 | 4 |
| KLRB1 | IKZF1 | 0.70616 | 8 | 0 | 7 |
| KLRB1 | DOCK10 | 0.701108 | 8 | 0 | 7 |
| KLRB1 | TNFAIP8L2 | 0.699217 | 6 | 0 | 5 |
For details and further investigation, click here
