| Full name: basic helix-loop-helix family member e22 | Alias Symbol: CAGL85|Beta3|bHLHe22 | ||
| Type: protein-coding gene | Cytoband: 8q12.3 | ||
| Entrez ID: 27319 | HGNC ID: HGNC:11963 | Ensembl Gene: ENSG00000180828 | OMIM ID: 613483 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of BHLHE22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BHLHE22 | 27319 | 228636_at | -0.2627 | 0.7052 | |
| GSE26886 | BHLHE22 | 27319 | 228636_at | -0.2595 | 0.3127 | |
| GSE45670 | BHLHE22 | 27319 | 228636_at | -1.5174 | 0.0007 | |
| GSE53622 | BHLHE22 | 27319 | 4132 | -0.8928 | 0.0000 | |
| GSE53624 | BHLHE22 | 27319 | 4132 | -0.7417 | 0.0000 | |
| GSE63941 | BHLHE22 | 27319 | 244323_at | 0.1336 | 0.3715 | |
| GSE77861 | BHLHE22 | 27319 | 228636_at | -0.1269 | 0.2447 | |
| GSE97050 | BHLHE22 | 27319 | A_32_P75581 | -0.4276 | 0.2382 | |
| SRP064894 | BHLHE22 | 27319 | RNAseq | -0.5685 | 0.1439 | |
| SRP133303 | BHLHE22 | 27319 | RNAseq | -0.2948 | 0.3855 | |
| SRP219564 | BHLHE22 | 27319 | RNAseq | 0.1520 | 0.7978 | |
| TCGA | BHLHE22 | 27319 | RNAseq | 0.0851 | 0.7472 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by BHLHE22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BHLHE22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BHLHE22 | 27319 | 12 | 1 | 17 | |
| GSE20123 | BHLHE22 | 27319 | 12 | 1 | 17 | |
| GSE43470 | BHLHE22 | 27319 | 15 | 3 | 25 | |
| GSE46452 | BHLHE22 | 27319 | 21 | 1 | 37 | |
| GSE47630 | BHLHE22 | 27319 | 23 | 1 | 16 | |
| GSE54993 | BHLHE22 | 27319 | 1 | 18 | 51 | |
| GSE54994 | BHLHE22 | 27319 | 30 | 0 | 23 | |
| GSE60625 | BHLHE22 | 27319 | 0 | 4 | 7 | |
| GSE74703 | BHLHE22 | 27319 | 13 | 2 | 21 | |
| GSE74704 | BHLHE22 | 27319 | 8 | 0 | 12 | |
| TCGA | BHLHE22 | 27319 | 47 | 5 | 44 |
Total number of gains: 182; Total number of losses: 36; Total Number of normals: 270.
Somatic mutations of BHLHE22:
Generating mutation plots.
Highly correlated genes for BHLHE22:
Showing top 20/563 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BHLHE22 | EBF1 | 0.810124 | 5 | 0 | 5 |
| BHLHE22 | TNFSF12 | 0.804423 | 3 | 0 | 3 |
| BHLHE22 | PSIP1 | 0.798247 | 3 | 0 | 3 |
| BHLHE22 | PTPRB | 0.777962 | 5 | 0 | 5 |
| BHLHE22 | TFPI | 0.777178 | 5 | 0 | 5 |
| BHLHE22 | CNRIP1 | 0.767284 | 7 | 0 | 6 |
| BHLHE22 | FLI1 | 0.761942 | 6 | 0 | 6 |
| BHLHE22 | EPDR1 | 0.753296 | 4 | 0 | 4 |
| BHLHE22 | PMP22 | 0.749991 | 5 | 0 | 5 |
| BHLHE22 | DAPK1 | 0.748497 | 3 | 0 | 3 |
| BHLHE22 | MFAP4 | 0.74556 | 6 | 0 | 6 |
| BHLHE22 | RCSD1 | 0.742092 | 6 | 0 | 6 |
| BHLHE22 | ZNF423 | 0.740292 | 5 | 0 | 5 |
| BHLHE22 | PDE1A | 0.727473 | 5 | 0 | 5 |
| BHLHE22 | PTBP2 | 0.726973 | 3 | 0 | 3 |
| BHLHE22 | SVEP1 | 0.72262 | 5 | 0 | 5 |
| BHLHE22 | NR2F1 | 0.721658 | 3 | 0 | 3 |
| BHLHE22 | RAB8B | 0.719235 | 5 | 0 | 5 |
| BHLHE22 | SOX17 | 0.717394 | 3 | 0 | 3 |
| BHLHE22 | CELF2 | 0.71737 | 5 | 0 | 5 |
For details and further investigation, click here
