| Full name: gamma-aminobutyric acid type A receptor beta3 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q12 | ||
| Entrez ID: 2562 | HGNC ID: HGNC:4083 | Ensembl Gene: ENSG00000166206 | OMIM ID: 137192 |
| Drug and gene relationship at DGIdb | |||
GABRB3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa05032 | Morphine addiction |
Expression of GABRB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRB3 | 2562 | 227830_at | -0.5908 | 0.0439 | |
| GSE20347 | GABRB3 | 2562 | 205850_s_at | 0.0400 | 0.5953 | |
| GSE23400 | GABRB3 | 2562 | 205850_s_at | 0.0470 | 0.2770 | |
| GSE26886 | GABRB3 | 2562 | 227830_at | 0.1524 | 0.7272 | |
| GSE29001 | GABRB3 | 2562 | 205850_s_at | 0.2531 | 0.2698 | |
| GSE38129 | GABRB3 | 2562 | 205850_s_at | 0.0813 | 0.3000 | |
| GSE45670 | GABRB3 | 2562 | 227830_at | 0.0546 | 0.8841 | |
| GSE53622 | GABRB3 | 2562 | 86131 | 0.1626 | 0.0343 | |
| GSE53624 | GABRB3 | 2562 | 86131 | 0.2006 | 0.0089 | |
| GSE63941 | GABRB3 | 2562 | 227830_at | 0.0231 | 0.9841 | |
| GSE77861 | GABRB3 | 2562 | 1569689_s_at | -0.0283 | 0.7783 | |
| GSE97050 | GABRB3 | 2562 | A_33_P3309206 | 0.2384 | 0.2544 | |
| SRP064894 | GABRB3 | 2562 | RNAseq | 1.3861 | 0.0169 | |
| SRP133303 | GABRB3 | 2562 | RNAseq | 0.3317 | 0.6028 | |
| SRP159526 | GABRB3 | 2562 | RNAseq | 1.4390 | 0.0858 | |
| SRP193095 | GABRB3 | 2562 | RNAseq | -0.4443 | 0.2890 | |
| TCGA | GABRB3 | 2562 | RNAseq | -1.7874 | 0.0005 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by GABRB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GABRB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRB3 | 2562 | 3 | 7 | 20 | |
| GSE20123 | GABRB3 | 2562 | 3 | 7 | 20 | |
| GSE43470 | GABRB3 | 2562 | 3 | 5 | 35 | |
| GSE46452 | GABRB3 | 2562 | 3 | 7 | 49 | |
| GSE47630 | GABRB3 | 2562 | 8 | 11 | 21 | |
| GSE54993 | GABRB3 | 2562 | 4 | 6 | 60 | |
| GSE54994 | GABRB3 | 2562 | 7 | 6 | 40 | |
| GSE60625 | GABRB3 | 2562 | 4 | 3 | 4 | |
| GSE74703 | GABRB3 | 2562 | 3 | 3 | 30 | |
| GSE74704 | GABRB3 | 2562 | 2 | 5 | 13 | |
| TCGA | GABRB3 | 2562 | 16 | 19 | 61 |
Total number of gains: 56; Total number of losses: 79; Total Number of normals: 353.
Somatic mutations of GABRB3:
Generating mutation plots.
Highly correlated genes for GABRB3:
Showing top 20/184 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRB3 | STRC | 0.753477 | 3 | 0 | 3 |
| GABRB3 | C1QL2 | 0.740775 | 3 | 0 | 3 |
| GABRB3 | DEFB121 | 0.73845 | 3 | 0 | 3 |
| GABRB3 | TMEM235 | 0.731836 | 3 | 0 | 3 |
| GABRB3 | CLTCL1 | 0.730566 | 3 | 0 | 3 |
| GABRB3 | MRGPRG | 0.730261 | 3 | 0 | 3 |
| GABRB3 | LGALS12 | 0.72429 | 3 | 0 | 3 |
| GABRB3 | PRLH | 0.717124 | 3 | 0 | 3 |
| GABRB3 | C20orf85 | 0.712663 | 4 | 0 | 4 |
| GABRB3 | C9orf153 | 0.710035 | 3 | 0 | 3 |
| GABRB3 | CDH22 | 0.709866 | 3 | 0 | 3 |
| GABRB3 | KRT32 | 0.709119 | 3 | 0 | 3 |
| GABRB3 | PLA2G2C | 0.708084 | 3 | 0 | 3 |
| GABRB3 | SHISA7 | 0.69999 | 3 | 0 | 3 |
| GABRB3 | PNPLA7 | 0.694133 | 4 | 0 | 4 |
| GABRB3 | ABCB1 | 0.692866 | 3 | 0 | 3 |
| GABRB3 | RNF180 | 0.690543 | 4 | 0 | 4 |
| GABRB3 | PANX2 | 0.687234 | 3 | 0 | 3 |
| GABRB3 | TRPM8 | 0.68397 | 3 | 0 | 3 |
| GABRB3 | CDRT15 | 0.68299 | 4 | 0 | 4 |
For details and further investigation, click here
