| Full name: gastrulation brain homeobox 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q37.2 | ||
| Entrez ID: 2637 | HGNC ID: HGNC:4186 | Ensembl Gene: ENSG00000168505 | OMIM ID: 601135 |
| Drug and gene relationship at DGIdb | |||
Expression of GBX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GBX2 | 2637 | 210560_at | 0.0575 | 0.8687 | |
| GSE20347 | GBX2 | 2637 | 210560_at | -0.0631 | 0.2994 | |
| GSE23400 | GBX2 | 2637 | 210560_at | -0.1552 | 0.0000 | |
| GSE26886 | GBX2 | 2637 | 210560_at | 0.0992 | 0.5028 | |
| GSE29001 | GBX2 | 2637 | 210560_at | -0.1532 | 0.0676 | |
| GSE38129 | GBX2 | 2637 | 210560_at | -0.0834 | 0.1160 | |
| GSE45670 | GBX2 | 2637 | 210560_at | 0.0537 | 0.6884 | |
| GSE53622 | GBX2 | 2637 | 73241 | 0.1019 | 0.3287 | |
| GSE53624 | GBX2 | 2637 | 73241 | -0.1426 | 0.2386 | |
| GSE63941 | GBX2 | 2637 | 210560_at | 0.4282 | 0.0279 | |
| GSE77861 | GBX2 | 2637 | 210560_at | -0.1061 | 0.3951 | |
| GSE97050 | GBX2 | 2637 | A_33_P3423969 | 0.0716 | 0.8292 | |
| TCGA | GBX2 | 2637 | RNAseq | 2.3369 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GBX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GBX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GBX2 | 2637 | 1 | 11 | 18 | |
| GSE20123 | GBX2 | 2637 | 1 | 11 | 18 | |
| GSE43470 | GBX2 | 2637 | 1 | 9 | 33 | |
| GSE46452 | GBX2 | 2637 | 0 | 5 | 54 | |
| GSE47630 | GBX2 | 2637 | 4 | 5 | 31 | |
| GSE54993 | GBX2 | 2637 | 3 | 2 | 65 | |
| GSE54994 | GBX2 | 2637 | 8 | 10 | 35 | |
| GSE60625 | GBX2 | 2637 | 0 | 3 | 8 | |
| GSE74703 | GBX2 | 2637 | 1 | 7 | 28 | |
| GSE74704 | GBX2 | 2637 | 1 | 5 | 14 | |
| TCGA | GBX2 | 2637 | 11 | 28 | 57 |
Total number of gains: 31; Total number of losses: 96; Total Number of normals: 361.
Somatic mutations of GBX2:
Generating mutation plots.
Highly correlated genes for GBX2:
Showing top 20/609 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GBX2 | KLHL35 | 0.7869 | 3 | 0 | 3 |
| GBX2 | LYL1 | 0.737313 | 3 | 0 | 3 |
| GBX2 | VEPH1 | 0.724427 | 3 | 0 | 3 |
| GBX2 | STK11 | 0.724377 | 3 | 0 | 3 |
| GBX2 | ZNF835 | 0.719159 | 3 | 0 | 3 |
| GBX2 | RNF17 | 0.709789 | 3 | 0 | 3 |
| GBX2 | IGFN1 | 0.701724 | 4 | 0 | 3 |
| GBX2 | C7orf61 | 0.691221 | 4 | 0 | 4 |
| GBX2 | KIF19 | 0.686742 | 3 | 0 | 3 |
| GBX2 | IL26 | 0.685994 | 3 | 0 | 3 |
| GBX2 | SWI5 | 0.685145 | 3 | 0 | 3 |
| GBX2 | OTOF | 0.685007 | 5 | 0 | 5 |
| GBX2 | LRTM2 | 0.674993 | 4 | 0 | 4 |
| GBX2 | PABPN1L | 0.671943 | 3 | 0 | 3 |
| GBX2 | ZNF687 | 0.671637 | 4 | 0 | 4 |
| GBX2 | DHRS7C | 0.668695 | 4 | 0 | 3 |
| GBX2 | SYT3 | 0.664628 | 3 | 0 | 3 |
| GBX2 | LOXHD1 | 0.664592 | 3 | 0 | 3 |
| GBX2 | SNX8 | 0.662312 | 4 | 0 | 3 |
| GBX2 | PGBD2 | 0.659975 | 3 | 0 | 3 |
For details and further investigation, click here
