PNPLA2

 

Full name: patatin like phospholipase domain containing 2 Alias Symbol: desnutrin|TTS-2.2|ATGL|FP17548|iPLA2zeta
Type: protein-coding gene Cytoband: 11p15.5
Entrez ID: 57104 HGNC ID: HGNC:30802 Ensembl Gene: ENSG00000177666 OMIM ID: 609059
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PNPLA2 involved pathways:

KEGG pathway Description View
hsa04923Regulation of lipolysis in adipocytes

 

Expression of PNPLA2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PNPLA2 57104 39854_r_at -0.0275 0.9456
GSE20347 PNPLA2 57104 39854_r_at 0.0652 0.5802
GSE23400 PNPLA2 57104 39854_r_at -0.0859 0.0042
GSE26886 PNPLA2 57104 39854_r_at 0.2021 0.2633
GSE29001 PNPLA2 57104 39854_r_at -0.3369 0.0390
GSE38129 PNPLA2 57104 39854_r_at -0.2665 0.0905
GSE45670 PNPLA2 57104 39854_r_at -0.0338 0.7550
GSE53622 PNPLA2 57104 112957 -0.7832 0.0000
GSE53624 PNPLA2 57104 112957 -0.6126 0.0000
GSE63941 PNPLA2 57104 39854_r_at 1.0804 0.0000
GSE77861 PNPLA2 57104 39854_r_at 0.1081 0.4252
GSE97050 PNPLA2 57104 A_33_P3219870 -0.0268 0.9250
SRP007169 PNPLA2 57104 RNAseq -2.2644 0.0000
SRP008496 PNPLA2 57104 RNAseq -2.1822 0.0000
SRP064894 PNPLA2 57104 RNAseq -0.5837 0.0238
SRP133303 PNPLA2 57104 RNAseq -0.7474 0.0006
SRP159526 PNPLA2 57104 RNAseq -1.0407 0.0000
SRP193095 PNPLA2 57104 RNAseq -0.5006 0.0591
SRP219564 PNPLA2 57104 RNAseq -0.3223 0.3966
TCGA PNPLA2 57104 RNAseq -0.2872 0.0000

Upregulated datasets: 1; Downregulated datasets: 3.  

 

Survival by PNPLA2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PNPLA2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PNPLA2 57104 1 11 18
GSE20123 PNPLA2 57104 1 12 17
GSE43470 PNPLA2 57104 1 10 32
GSE46452 PNPLA2 57104 7 8 44
GSE47630 PNPLA2 57104 4 12 24
GSE54993 PNPLA2 57104 3 1 66
GSE54994 PNPLA2 57104 1 12 40
GSE60625 PNPLA2 57104 0 0 11
GSE74703 PNPLA2 57104 1 8 27
GSE74704 PNPLA2 57104 0 8 12
TCGA PNPLA2 57104 8 38 50

Total number of gains: 27; Total number of losses: 120; Total Number of normals: 341.  

 

Somatic mutations of PNPLA2:

 

Generating mutation plots.

 

Highly correlated genes for PNPLA2:

 

Showing top 20/700 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PNPLA2TRPM30.781111404
PNPLA2LINC005200.77149303
PNPLA2GLP1R0.755694707
PNPLA2C11orf860.734608303
PNPLA2PHGR10.73029303
PNPLA2SLC8A30.711884505
PNPLA2LAIR20.70748404
PNPLA2VWA3A0.702431505
PNPLA2MYH140.701778403
PNPLA2RNF1230.700979605
PNPLA2SIGLEC70.698225706
PNPLA2SNORA71A0.692927403
PNPLA2UCN30.691768303
PNPLA2HNF1B0.68738210010
PNPLA2BPIFB40.686459404
PNPLA2IL17C0.684519303
PNPLA2BCAN0.684283807
PNPLA2RAB3IL10.682181907
PNPLA2LRRC40.68061303
PNPLA2AMHR20.680456908

For details and further investigation, click here