| Full name: delta like canonical Notch ligand 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q15.1 | ||
| Entrez ID: 54567 | HGNC ID: HGNC:2910 | Ensembl Gene: ENSG00000128917 | OMIM ID: 605185 |
| Drug and gene relationship at DGIdb | |||
DLL4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of DLL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DLL4 | 54567 | 223525_at | 0.1849 | 0.6051 | |
| GSE26886 | DLL4 | 54567 | 223525_at | 0.1637 | 0.2049 | |
| GSE45670 | DLL4 | 54567 | 223525_at | 0.0111 | 0.9225 | |
| GSE53622 | DLL4 | 54567 | 82157 | 0.4574 | 0.0001 | |
| GSE53624 | DLL4 | 54567 | 82157 | 0.4901 | 0.0000 | |
| GSE63941 | DLL4 | 54567 | 223525_at | 0.2149 | 0.1645 | |
| GSE77861 | DLL4 | 54567 | 223525_at | -0.0186 | 0.8979 | |
| GSE97050 | DLL4 | 54567 | A_23_P419641 | 0.3087 | 0.3687 | |
| SRP007169 | DLL4 | 54567 | RNAseq | 1.3625 | 0.0287 | |
| SRP008496 | DLL4 | 54567 | RNAseq | 1.3917 | 0.0033 | |
| SRP064894 | DLL4 | 54567 | RNAseq | 1.1948 | 0.0000 | |
| SRP133303 | DLL4 | 54567 | RNAseq | 0.3593 | 0.0714 | |
| SRP159526 | DLL4 | 54567 | RNAseq | 0.7950 | 0.0791 | |
| SRP193095 | DLL4 | 54567 | RNAseq | 0.8969 | 0.0004 | |
| SRP219564 | DLL4 | 54567 | RNAseq | 0.2418 | 0.5631 | |
| TCGA | DLL4 | 54567 | RNAseq | -0.1718 | 0.1235 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DLL4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DLL4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DLL4 | 54567 | 3 | 6 | 21 | |
| GSE20123 | DLL4 | 54567 | 3 | 6 | 21 | |
| GSE43470 | DLL4 | 54567 | 4 | 6 | 33 | |
| GSE46452 | DLL4 | 54567 | 3 | 7 | 49 | |
| GSE47630 | DLL4 | 54567 | 8 | 11 | 21 | |
| GSE54993 | DLL4 | 54567 | 4 | 6 | 60 | |
| GSE54994 | DLL4 | 54567 | 6 | 7 | 40 | |
| GSE60625 | DLL4 | 54567 | 4 | 0 | 7 | |
| GSE74703 | DLL4 | 54567 | 4 | 5 | 27 | |
| GSE74704 | DLL4 | 54567 | 2 | 4 | 14 | |
| TCGA | DLL4 | 54567 | 11 | 18 | 67 |
Total number of gains: 52; Total number of losses: 76; Total Number of normals: 360.
Somatic mutations of DLL4:
Generating mutation plots.
Highly correlated genes for DLL4:
Showing top 20/251 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DLL4 | CD22 | 0.786464 | 3 | 0 | 3 |
| DLL4 | PTGES2 | 0.764961 | 3 | 0 | 3 |
| DLL4 | GLP1R | 0.749255 | 4 | 0 | 4 |
| DLL4 | NKX2-5 | 0.715622 | 3 | 0 | 3 |
| DLL4 | SLC11A1 | 0.698268 | 4 | 0 | 4 |
| DLL4 | GAPDH | 0.69499 | 3 | 0 | 3 |
| DLL4 | TFDP3 | 0.677689 | 3 | 0 | 3 |
| DLL4 | KCNIP2-AS1 | 0.677599 | 4 | 0 | 4 |
| DLL4 | SLAMF1 | 0.668484 | 3 | 0 | 3 |
| DLL4 | JOSD1 | 0.665016 | 4 | 0 | 4 |
| DLL4 | TNS4 | 0.664907 | 3 | 0 | 3 |
| DLL4 | SLC32A1 | 0.6643 | 3 | 0 | 3 |
| DLL4 | C10orf95 | 0.662946 | 3 | 0 | 3 |
| DLL4 | MIER2 | 0.661994 | 3 | 0 | 3 |
| DLL4 | USP5 | 0.660182 | 4 | 0 | 4 |
| DLL4 | PANX2 | 0.660022 | 3 | 0 | 3 |
| DLL4 | ADRB3 | 0.658857 | 3 | 0 | 3 |
| DLL4 | ZNF384 | 0.656326 | 3 | 0 | 3 |
| DLL4 | SERPINA1 | 0.654891 | 3 | 0 | 3 |
| DLL4 | PCDH17 | 0.654515 | 4 | 0 | 4 |
For details and further investigation, click here
