| Full name: GDP-mannose pyrophosphorylase A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 29926 | HGNC ID: HGNC:22923 | Ensembl Gene: ENSG00000144591 | OMIM ID: 615495 |
| Drug and gene relationship at DGIdb | |||
Expression of GMPPA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GMPPA | 29926 | 218070_s_at | 0.1919 | 0.6206 | |
| GSE20347 | GMPPA | 29926 | 218070_s_at | 0.0674 | 0.5946 | |
| GSE23400 | GMPPA | 29926 | 218070_s_at | 0.2644 | 0.0000 | |
| GSE26886 | GMPPA | 29926 | 218070_s_at | 0.5687 | 0.0120 | |
| GSE29001 | GMPPA | 29926 | 218070_s_at | 0.0290 | 0.9153 | |
| GSE38129 | GMPPA | 29926 | 218070_s_at | 0.1661 | 0.1245 | |
| GSE45670 | GMPPA | 29926 | 218070_s_at | 0.3414 | 0.0122 | |
| GSE53622 | GMPPA | 29926 | 8825 | 0.4944 | 0.0000 | |
| GSE53624 | GMPPA | 29926 | 8825 | 0.2468 | 0.0013 | |
| GSE63941 | GMPPA | 29926 | 218070_s_at | 0.6559 | 0.0539 | |
| GSE77861 | GMPPA | 29926 | 218070_s_at | 0.1523 | 0.5519 | |
| GSE97050 | GMPPA | 29926 | A_23_P67913 | 0.6057 | 0.0934 | |
| SRP007169 | GMPPA | 29926 | RNAseq | -0.6961 | 0.1468 | |
| SRP008496 | GMPPA | 29926 | RNAseq | -0.7084 | 0.0059 | |
| SRP064894 | GMPPA | 29926 | RNAseq | 0.9116 | 0.0011 | |
| SRP133303 | GMPPA | 29926 | RNAseq | 0.4731 | 0.0232 | |
| SRP159526 | GMPPA | 29926 | RNAseq | 0.1125 | 0.5177 | |
| SRP193095 | GMPPA | 29926 | RNAseq | -0.0797 | 0.6593 | |
| SRP219564 | GMPPA | 29926 | RNAseq | 0.6458 | 0.0338 | |
| TCGA | GMPPA | 29926 | RNAseq | -0.0551 | 0.3293 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GMPPA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GMPPA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GMPPA | 29926 | 2 | 14 | 14 | |
| GSE20123 | GMPPA | 29926 | 2 | 13 | 15 | |
| GSE43470 | GMPPA | 29926 | 1 | 6 | 36 | |
| GSE46452 | GMPPA | 29926 | 0 | 5 | 54 | |
| GSE47630 | GMPPA | 29926 | 4 | 5 | 31 | |
| GSE54993 | GMPPA | 29926 | 1 | 2 | 67 | |
| GSE54994 | GMPPA | 29926 | 8 | 9 | 36 | |
| GSE60625 | GMPPA | 29926 | 0 | 3 | 8 | |
| GSE74703 | GMPPA | 29926 | 1 | 5 | 30 | |
| GSE74704 | GMPPA | 29926 | 2 | 7 | 11 | |
| TCGA | GMPPA | 29926 | 13 | 25 | 58 |
Total number of gains: 34; Total number of losses: 94; Total Number of normals: 360.
Somatic mutations of GMPPA:
Generating mutation plots.
Highly correlated genes for GMPPA:
Showing top 20/764 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GMPPA | LRP1 | 0.756151 | 3 | 0 | 3 |
| GMPPA | OGFOD1 | 0.753234 | 3 | 0 | 3 |
| GMPPA | MYPOP | 0.747651 | 3 | 0 | 3 |
| GMPPA | JKAMP | 0.714009 | 4 | 0 | 4 |
| GMPPA | UBR4 | 0.700281 | 3 | 0 | 3 |
| GMPPA | EARS2 | 0.69212 | 4 | 0 | 4 |
| GMPPA | TAF2 | 0.690118 | 4 | 0 | 3 |
| GMPPA | ZDHHC12 | 0.688853 | 3 | 0 | 3 |
| GMPPA | TCTN1 | 0.687782 | 3 | 0 | 3 |
| GMPPA | ZNF628 | 0.685576 | 3 | 0 | 3 |
| GMPPA | TCTN3 | 0.684248 | 3 | 0 | 3 |
| GMPPA | FAM110A | 0.677764 | 4 | 0 | 3 |
| GMPPA | CAMKK1 | 0.677659 | 3 | 0 | 3 |
| GMPPA | C3orf33 | 0.675093 | 3 | 0 | 3 |
| GMPPA | SLC2A4RG | 0.674739 | 5 | 0 | 5 |
| GMPPA | RSPRY1 | 0.674567 | 4 | 0 | 3 |
| GMPPA | SSBP4 | 0.674495 | 3 | 0 | 3 |
| GMPPA | CCT8 | 0.674196 | 3 | 0 | 3 |
| GMPPA | EPN1 | 0.668294 | 4 | 0 | 4 |
| GMPPA | HMOX2 | 0.667697 | 3 | 0 | 3 |
For details and further investigation, click here
