| Full name: glutamyl-tRNA synthetase 2, mitochondrial | Alias Symbol: KIAA1970|MSE1|mtGlnRS | ||
| Type: protein-coding gene | Cytoband: 16p12.2 | ||
| Entrez ID: 124454 | HGNC ID: HGNC:29419 | Ensembl Gene: ENSG00000103356 | OMIM ID: 612799 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EARS2 | 124454 | 227374_at | 0.5426 | 0.2928 | |
| GSE26886 | EARS2 | 124454 | 1563796_s_at | 0.0710 | 0.7502 | |
| GSE45670 | EARS2 | 124454 | 227374_at | 0.6804 | 0.0000 | |
| GSE53622 | EARS2 | 124454 | 87008 | 0.5033 | 0.0000 | |
| GSE53624 | EARS2 | 124454 | 87008 | 0.7413 | 0.0000 | |
| GSE63941 | EARS2 | 124454 | 227374_at | 0.0136 | 0.9727 | |
| GSE77861 | EARS2 | 124454 | 227374_at | 0.0174 | 0.9325 | |
| GSE97050 | EARS2 | 124454 | A_23_P152353 | 0.3783 | 0.2253 | |
| SRP007169 | EARS2 | 124454 | RNAseq | 1.3047 | 0.0011 | |
| SRP008496 | EARS2 | 124454 | RNAseq | 0.9665 | 0.0006 | |
| SRP064894 | EARS2 | 124454 | RNAseq | 0.3539 | 0.0241 | |
| SRP133303 | EARS2 | 124454 | RNAseq | 0.7560 | 0.0002 | |
| SRP159526 | EARS2 | 124454 | RNAseq | 0.4289 | 0.0371 | |
| SRP193095 | EARS2 | 124454 | RNAseq | 0.2994 | 0.0015 | |
| SRP219564 | EARS2 | 124454 | RNAseq | 0.3816 | 0.2136 | |
| TCGA | EARS2 | 124454 | RNAseq | 0.0252 | 0.6538 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by EARS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EARS2 | 124454 | 6 | 4 | 20 | |
| GSE20123 | EARS2 | 124454 | 6 | 3 | 21 | |
| GSE43470 | EARS2 | 124454 | 3 | 3 | 37 | |
| GSE46452 | EARS2 | 124454 | 38 | 1 | 20 | |
| GSE47630 | EARS2 | 124454 | 11 | 6 | 23 | |
| GSE54993 | EARS2 | 124454 | 3 | 5 | 62 | |
| GSE54994 | EARS2 | 124454 | 4 | 10 | 39 | |
| GSE60625 | EARS2 | 124454 | 4 | 0 | 7 | |
| GSE74703 | EARS2 | 124454 | 3 | 2 | 31 | |
| GSE74704 | EARS2 | 124454 | 3 | 1 | 16 | |
| TCGA | EARS2 | 124454 | 19 | 13 | 64 |
Total number of gains: 100; Total number of losses: 48; Total Number of normals: 340.
Somatic mutations of EARS2:
Generating mutation plots.
Highly correlated genes for EARS2:
Showing top 20/928 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EARS2 | ALG1 | 0.833581 | 3 | 0 | 3 |
| EARS2 | DTYMK | 0.78562 | 5 | 0 | 5 |
| EARS2 | SNRPD3 | 0.77772 | 3 | 0 | 3 |
| EARS2 | CHCHD5 | 0.761745 | 3 | 0 | 3 |
| EARS2 | NPRL3 | 0.757053 | 4 | 0 | 4 |
| EARS2 | ZBED4 | 0.753717 | 3 | 0 | 3 |
| EARS2 | MRPL42 | 0.751652 | 3 | 0 | 3 |
| EARS2 | BRCA1 | 0.7512 | 5 | 0 | 5 |
| EARS2 | HMGB3 | 0.745236 | 3 | 0 | 3 |
| EARS2 | KLHL11 | 0.744527 | 3 | 0 | 3 |
| EARS2 | DSCC1 | 0.740866 | 3 | 0 | 3 |
| EARS2 | CCT6A | 0.739342 | 3 | 0 | 3 |
| EARS2 | CCNF | 0.7383 | 5 | 0 | 5 |
| EARS2 | GINS1 | 0.737576 | 5 | 0 | 5 |
| EARS2 | SLC25A17 | 0.735243 | 5 | 0 | 5 |
| EARS2 | METTL23 | 0.732455 | 4 | 0 | 4 |
| EARS2 | MRPS34 | 0.731426 | 6 | 0 | 5 |
| EARS2 | PPIL1 | 0.730236 | 5 | 0 | 5 |
| EARS2 | POLR2G | 0.728531 | 5 | 0 | 5 |
| EARS2 | RAD18 | 0.728491 | 4 | 0 | 3 |
For details and further investigation, click here
