| Full name: arginyl-tRNA synthetase 2, mitochondrial | Alias Symbol: MGC14993|MGC23778|PRO1992|dJ382I10.6|DALRD2 | ||
| Type: protein-coding gene | Cytoband: 6q15 | ||
| Entrez ID: 57038 | HGNC ID: HGNC:21406 | Ensembl Gene: ENSG00000146282 | OMIM ID: 611524 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RARS2 | 57038 | 225264_at | -0.3831 | 0.2130 | |
| GSE26886 | RARS2 | 57038 | 225264_at | -0.0063 | 0.9775 | |
| GSE45670 | RARS2 | 57038 | 225264_at | -0.0472 | 0.6483 | |
| GSE53622 | RARS2 | 57038 | 137961 | -0.0635 | 0.3575 | |
| GSE53624 | RARS2 | 57038 | 137961 | 0.0203 | 0.7457 | |
| GSE63941 | RARS2 | 57038 | 225264_at | -0.8834 | 0.0024 | |
| GSE77861 | RARS2 | 57038 | 225264_at | 0.3249 | 0.2664 | |
| GSE97050 | RARS2 | 57038 | A_23_P214211 | 0.1229 | 0.5502 | |
| SRP007169 | RARS2 | 57038 | RNAseq | -0.1125 | 0.7643 | |
| SRP008496 | RARS2 | 57038 | RNAseq | -0.0411 | 0.8650 | |
| SRP064894 | RARS2 | 57038 | RNAseq | 0.0990 | 0.4465 | |
| SRP133303 | RARS2 | 57038 | RNAseq | 0.2149 | 0.2450 | |
| SRP159526 | RARS2 | 57038 | RNAseq | 0.1046 | 0.5777 | |
| SRP193095 | RARS2 | 57038 | RNAseq | -0.2455 | 0.0010 | |
| SRP219564 | RARS2 | 57038 | RNAseq | -0.1346 | 0.4962 | |
| TCGA | RARS2 | 57038 | RNAseq | -0.0295 | 0.5765 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RARS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RARS2 | 57038 | 1 | 4 | 25 | |
| GSE20123 | RARS2 | 57038 | 1 | 3 | 26 | |
| GSE43470 | RARS2 | 57038 | 3 | 1 | 39 | |
| GSE46452 | RARS2 | 57038 | 2 | 11 | 46 | |
| GSE47630 | RARS2 | 57038 | 8 | 6 | 26 | |
| GSE54993 | RARS2 | 57038 | 3 | 2 | 65 | |
| GSE54994 | RARS2 | 57038 | 8 | 8 | 37 | |
| GSE60625 | RARS2 | 57038 | 0 | 1 | 10 | |
| GSE74703 | RARS2 | 57038 | 3 | 1 | 32 | |
| GSE74704 | RARS2 | 57038 | 0 | 2 | 18 | |
| TCGA | RARS2 | 57038 | 5 | 21 | 70 |
Total number of gains: 34; Total number of losses: 60; Total Number of normals: 394.
Somatic mutations of RARS2:
Generating mutation plots.
Highly correlated genes for RARS2:
Showing top 20/171 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RARS2 | RPS6KB1 | 0.805431 | 3 | 0 | 3 |
| RARS2 | ARL15 | 0.802519 | 3 | 0 | 3 |
| RARS2 | OPTN | 0.790528 | 3 | 0 | 3 |
| RARS2 | RPS4Y1 | 0.782239 | 3 | 0 | 3 |
| RARS2 | GNG12 | 0.77394 | 3 | 0 | 3 |
| RARS2 | TEX2 | 0.74628 | 3 | 0 | 3 |
| RARS2 | LYSMD2 | 0.742296 | 3 | 0 | 3 |
| RARS2 | MDFIC | 0.736395 | 3 | 0 | 3 |
| RARS2 | RPL41 | 0.732395 | 3 | 0 | 3 |
| RARS2 | LYSMD3 | 0.729668 | 3 | 0 | 3 |
| RARS2 | ANKRD6 | 0.726481 | 3 | 0 | 3 |
| RARS2 | EPAS1 | 0.722095 | 3 | 0 | 3 |
| RARS2 | ENTPD4 | 0.720633 | 3 | 0 | 3 |
| RARS2 | USO1 | 0.720532 | 3 | 0 | 3 |
| RARS2 | TMTC3 | 0.717521 | 3 | 0 | 3 |
| RARS2 | KCNJ2 | 0.715975 | 4 | 0 | 4 |
| RARS2 | CD44 | 0.714497 | 4 | 0 | 3 |
| RARS2 | IL33 | 0.714228 | 3 | 0 | 3 |
| RARS2 | PPP3CC | 0.712957 | 4 | 0 | 3 |
| RARS2 | SLC16A7 | 0.712061 | 3 | 0 | 3 |
For details and further investigation, click here
