| Full name: semaphorin 6A | Alias Symbol: KIAA1368|SEMA6A1|SEMA|HT018 | ||
| Type: protein-coding gene | Cytoband: 5q23.1 | ||
| Entrez ID: 57556 | HGNC ID: HGNC:10738 | Ensembl Gene: ENSG00000092421 | OMIM ID: 605885 |
| Drug and gene relationship at DGIdb | |||
Expression of SEMA6A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEMA6A | 57556 | 223449_at | -0.0924 | 0.9264 | |
| GSE20347 | SEMA6A | 57556 | 220454_s_at | -0.0962 | 0.4529 | |
| GSE23400 | SEMA6A | 57556 | 220454_s_at | -0.0809 | 0.1149 | |
| GSE26886 | SEMA6A | 57556 | 223449_at | 0.2990 | 0.4353 | |
| GSE29001 | SEMA6A | 57556 | 220454_s_at | -0.2359 | 0.1667 | |
| GSE38129 | SEMA6A | 57556 | 220454_s_at | -0.2165 | 0.1174 | |
| GSE45670 | SEMA6A | 57556 | 223449_at | -0.4496 | 0.1465 | |
| GSE53622 | SEMA6A | 57556 | 65469 | -0.4094 | 0.0169 | |
| GSE53624 | SEMA6A | 57556 | 65469 | -0.3614 | 0.0057 | |
| GSE63941 | SEMA6A | 57556 | 223449_at | -2.7733 | 0.0000 | |
| GSE77861 | SEMA6A | 57556 | 223449_at | -0.0427 | 0.8684 | |
| GSE97050 | SEMA6A | 57556 | A_24_P213478 | -0.1010 | 0.7534 | |
| SRP007169 | SEMA6A | 57556 | RNAseq | 0.7820 | 0.4046 | |
| SRP064894 | SEMA6A | 57556 | RNAseq | -0.0969 | 0.7442 | |
| SRP133303 | SEMA6A | 57556 | RNAseq | -0.1272 | 0.6552 | |
| SRP159526 | SEMA6A | 57556 | RNAseq | 0.7146 | 0.1843 | |
| SRP193095 | SEMA6A | 57556 | RNAseq | -0.0719 | 0.7721 | |
| SRP219564 | SEMA6A | 57556 | RNAseq | -0.6055 | 0.1080 | |
| TCGA | SEMA6A | 57556 | RNAseq | -0.2359 | 0.0983 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SEMA6A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEMA6A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEMA6A | 57556 | 1 | 13 | 16 | |
| GSE20123 | SEMA6A | 57556 | 1 | 13 | 16 | |
| GSE43470 | SEMA6A | 57556 | 3 | 8 | 32 | |
| GSE46452 | SEMA6A | 57556 | 0 | 27 | 32 | |
| GSE47630 | SEMA6A | 57556 | 0 | 21 | 19 | |
| GSE54993 | SEMA6A | 57556 | 9 | 1 | 60 | |
| GSE54994 | SEMA6A | 57556 | 1 | 15 | 37 | |
| GSE60625 | SEMA6A | 57556 | 0 | 0 | 11 | |
| GSE74703 | SEMA6A | 57556 | 2 | 6 | 28 | |
| GSE74704 | SEMA6A | 57556 | 1 | 7 | 12 | |
| TCGA | SEMA6A | 57556 | 2 | 42 | 52 |
Total number of gains: 20; Total number of losses: 153; Total Number of normals: 315.
Somatic mutations of SEMA6A:
Generating mutation plots.
Highly correlated genes for SEMA6A:
Showing top 20/354 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEMA6A | MAGI1 | 0.802058 | 3 | 0 | 3 |
| SEMA6A | RGL1 | 0.795525 | 3 | 0 | 3 |
| SEMA6A | CNTF | 0.785162 | 3 | 0 | 3 |
| SEMA6A | LYSMD3 | 0.76929 | 3 | 0 | 3 |
| SEMA6A | GNG12 | 0.76416 | 3 | 0 | 3 |
| SEMA6A | IL13RA2 | 0.757879 | 3 | 0 | 3 |
| SEMA6A | LRRK2 | 0.754105 | 3 | 0 | 3 |
| SEMA6A | RAPGEF1 | 0.753218 | 3 | 0 | 3 |
| SEMA6A | NAPB | 0.7409 | 3 | 0 | 3 |
| SEMA6A | TBC1D20 | 0.734544 | 3 | 0 | 3 |
| SEMA6A | PAPSS2 | 0.72682 | 3 | 0 | 3 |
| SEMA6A | P2RY13 | 0.721017 | 3 | 0 | 3 |
| SEMA6A | CDH6 | 0.713244 | 5 | 0 | 4 |
| SEMA6A | SELP | 0.711573 | 3 | 0 | 3 |
| SEMA6A | MAN1A2 | 0.706316 | 4 | 0 | 3 |
| SEMA6A | MAP1A | 0.705803 | 4 | 0 | 3 |
| SEMA6A | CNRIP1 | 0.704086 | 4 | 0 | 3 |
| SEMA6A | TCF25 | 0.701777 | 3 | 0 | 3 |
| SEMA6A | HUWE1 | 0.701554 | 3 | 0 | 3 |
| SEMA6A | GRIN3A | 0.700582 | 3 | 0 | 3 |
For details and further investigation, click here
