| Full name: mixed lineage kinase domain like pseudokinase | Alias Symbol: FLJ34389 | ||
| Type: protein-coding gene | Cytoband: 16q22.3 | ||
| Entrez ID: 197259 | HGNC ID: HGNC:26617 | Ensembl Gene: ENSG00000168404 | OMIM ID: 615153 |
| Drug and gene relationship at DGIdb | |||
MLKL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04668 | TNF signaling pathway |
Expression of MLKL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MLKL | 197259 | 238025_at | -0.2402 | 0.6370 | |
| GSE26886 | MLKL | 197259 | 238025_at | -1.4304 | 0.0000 | |
| GSE45670 | MLKL | 197259 | 238025_at | 0.2294 | 0.1837 | |
| GSE53622 | MLKL | 197259 | 59447 | 0.0424 | 0.7074 | |
| GSE53624 | MLKL | 197259 | 59447 | -0.1102 | 0.2602 | |
| GSE63941 | MLKL | 197259 | 238025_at | 0.1409 | 0.9195 | |
| GSE77861 | MLKL | 197259 | 238025_at | -0.4747 | 0.1617 | |
| GSE97050 | MLKL | 197259 | A_23_P61050 | 0.5943 | 0.1470 | |
| SRP007169 | MLKL | 197259 | RNAseq | 0.0968 | 0.8414 | |
| SRP064894 | MLKL | 197259 | RNAseq | 0.0265 | 0.8613 | |
| SRP133303 | MLKL | 197259 | RNAseq | -0.0872 | 0.5962 | |
| SRP159526 | MLKL | 197259 | RNAseq | -0.9528 | 0.0157 | |
| SRP193095 | MLKL | 197259 | RNAseq | -0.0972 | 0.4363 | |
| SRP219564 | MLKL | 197259 | RNAseq | 0.0097 | 0.9773 | |
| TCGA | MLKL | 197259 | RNAseq | 0.0770 | 0.3396 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MLKL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MLKL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MLKL | 197259 | 6 | 1 | 23 | |
| GSE20123 | MLKL | 197259 | 6 | 1 | 23 | |
| GSE43470 | MLKL | 197259 | 2 | 8 | 33 | |
| GSE46452 | MLKL | 197259 | 37 | 2 | 20 | |
| GSE47630 | MLKL | 197259 | 11 | 8 | 21 | |
| GSE54993 | MLKL | 197259 | 2 | 4 | 64 | |
| GSE54994 | MLKL | 197259 | 8 | 10 | 35 | |
| GSE60625 | MLKL | 197259 | 4 | 0 | 7 | |
| GSE74703 | MLKL | 197259 | 2 | 5 | 29 | |
| GSE74704 | MLKL | 197259 | 3 | 0 | 17 | |
| TCGA | MLKL | 197259 | 25 | 15 | 56 |
Total number of gains: 106; Total number of losses: 54; Total Number of normals: 328.
Somatic mutations of MLKL:
Generating mutation plots.
Highly correlated genes for MLKL:
Showing top 20/507 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MLKL | CSNK1A1 | 0.827489 | 3 | 0 | 3 |
| MLKL | RBM20 | 0.786276 | 3 | 0 | 3 |
| MLKL | TNIP1 | 0.785043 | 3 | 0 | 3 |
| MLKL | CYLD | 0.765845 | 3 | 0 | 3 |
| MLKL | RREB1 | 0.7575 | 3 | 0 | 3 |
| MLKL | NPC1 | 0.756553 | 3 | 0 | 3 |
| MLKL | PDIK1L | 0.752527 | 3 | 0 | 3 |
| MLKL | CLCN3 | 0.752256 | 3 | 0 | 3 |
| MLKL | CTBS | 0.749961 | 4 | 0 | 4 |
| MLKL | FBXO3 | 0.749894 | 3 | 0 | 3 |
| MLKL | HECW2 | 0.749116 | 4 | 0 | 4 |
| MLKL | PLEKHM1 | 0.748282 | 3 | 0 | 3 |
| MLKL | ITPR2 | 0.746558 | 3 | 0 | 3 |
| MLKL | KALRN | 0.745286 | 3 | 0 | 3 |
| MLKL | GTF3C1 | 0.744364 | 3 | 0 | 3 |
| MLKL | TP53AIP1 | 0.740288 | 3 | 0 | 3 |
| MLKL | BNIP3 | 0.740149 | 3 | 0 | 3 |
| MLKL | RAP2C | 0.735906 | 5 | 0 | 5 |
| MLKL | ZNF844 | 0.734351 | 3 | 0 | 3 |
| MLKL | SLC12A6 | 0.734241 | 3 | 0 | 3 |
For details and further investigation, click here
