GNG13

 

Full name: G protein subunit gamma 13 Alias Symbol: h2-35|G(gamma)13
Type: protein-coding gene Cytoband: 16p13.3
Entrez ID: 51764 HGNC ID: HGNC:14131 Ensembl Gene: ENSG00000127588 OMIM ID: 607298
Drug and gene relationship at DGIdb

 

GNG13 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04740Olfactory transduction
hsa04742Taste transduction
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNG13:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNG13 51764 220806_x_at 0.1023 0.7360
GSE20347 GNG13 51764 220806_x_at 0.0451 0.5992
GSE23400 GNG13 51764 220806_x_at -0.0361 0.3572
GSE26886 GNG13 51764 220806_x_at -0.0122 0.9200
GSE29001 GNG13 51764 220806_x_at -0.0274 0.8820
GSE38129 GNG13 51764 220806_x_at -0.0716 0.3119
GSE45670 GNG13 51764 220806_x_at 0.1105 0.2099
GSE53622 GNG13 51764 125595 0.6986 0.0034
GSE53624 GNG13 51764 125595 0.5072 0.0008
GSE63941 GNG13 51764 220806_x_at 0.2718 0.1044
GSE77861 GNG13 51764 220806_x_at -0.0018 0.9883
GSE97050 GNG13 51764 A_23_P54736 -0.1712 0.6606
TCGA GNG13 51764 RNAseq -1.7969 0.0070

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by GNG13 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNG13:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNG13 51764 5 5 20
GSE20123 GNG13 51764 5 4 21
GSE43470 GNG13 51764 4 7 32
GSE46452 GNG13 51764 38 1 20
GSE47630 GNG13 51764 13 6 21
GSE54993 GNG13 51764 3 5 62
GSE54994 GNG13 51764 5 9 39
GSE60625 GNG13 51764 4 0 7
GSE74703 GNG13 51764 4 5 27
GSE74704 GNG13 51764 3 2 15
TCGA GNG13 51764 20 14 62

Total number of gains: 104; Total number of losses: 58; Total Number of normals: 326.  

 

Somatic mutations of GNG13:

 

Generating mutation plots.

 

Highly correlated genes for GNG13:

 

Showing top 20/780 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNG13NTNG10.708147404
GNG13CHRNB40.70705303
GNG13PRAMEF120.700782505
GNG13ART10.695792505
GNG13OR10H30.69332505
GNG13DEFB108B0.691047303
GNG13CHRNB30.68465404
GNG13IFNA170.684306404
GNG13C60.679974404
GNG13OR4D60.678276303
GNG13HECW10.672288604
GNG13GOLGA7B0.668317404
GNG13ABCA90.667961303
GNG13PRR7-AS10.666038303
GNG13ECE20.66434403
GNG13TRPM30.663676706
GNG13NEUROD40.662786404
GNG13LGALS120.662717404
GNG13RHPN1-AS10.659666404
GNG13KIR3DL30.659305706

For details and further investigation, click here