| Full name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | Alias Symbol: KIAA0322|NEDL1 | ||
| Type: protein-coding gene | Cytoband: 7p14.1-p13 | ||
| Entrez ID: 23072 | HGNC ID: HGNC:22195 | Ensembl Gene: ENSG00000002746 | OMIM ID: 610384 |
| Drug and gene relationship at DGIdb | |||
Expression of HECW1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HECW1 | 23072 | 215584_at | -0.0425 | 0.9074 | |
| GSE20347 | HECW1 | 23072 | 215584_at | 0.1416 | 0.3060 | |
| GSE23400 | HECW1 | 23072 | 215584_at | -0.0704 | 0.2032 | |
| GSE26886 | HECW1 | 23072 | 215584_at | 0.0467 | 0.7757 | |
| GSE29001 | HECW1 | 23072 | 215584_at | 0.0061 | 0.9747 | |
| GSE38129 | HECW1 | 23072 | 215584_at | -0.0799 | 0.4503 | |
| GSE45670 | HECW1 | 23072 | 215584_at | 0.1606 | 0.0918 | |
| GSE53622 | HECW1 | 23072 | 54130 | 0.5849 | 0.0000 | |
| GSE53624 | HECW1 | 23072 | 54130 | 0.6919 | 0.0000 | |
| GSE63941 | HECW1 | 23072 | 215584_at | 0.0376 | 0.8350 | |
| GSE77861 | HECW1 | 23072 | 215584_at | -0.0957 | 0.3323 | |
| GSE97050 | HECW1 | 23072 | A_23_P319027 | 0.1052 | 0.6390 | |
| SRP007169 | HECW1 | 23072 | RNAseq | 2.2096 | 0.0324 | |
| SRP133303 | HECW1 | 23072 | RNAseq | 1.7727 | 0.0000 | |
| SRP159526 | HECW1 | 23072 | RNAseq | 1.5963 | 0.0108 | |
| SRP193095 | HECW1 | 23072 | RNAseq | 1.3668 | 0.0000 | |
| SRP219564 | HECW1 | 23072 | RNAseq | 1.8654 | 0.0491 | |
| TCGA | HECW1 | 23072 | RNAseq | 0.8041 | 0.0066 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by HECW1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HECW1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HECW1 | 23072 | 15 | 0 | 15 | |
| GSE20123 | HECW1 | 23072 | 14 | 0 | 16 | |
| GSE43470 | HECW1 | 23072 | 4 | 0 | 39 | |
| GSE46452 | HECW1 | 23072 | 11 | 1 | 47 | |
| GSE47630 | HECW1 | 23072 | 8 | 1 | 31 | |
| GSE54993 | HECW1 | 23072 | 0 | 8 | 62 | |
| GSE54994 | HECW1 | 23072 | 17 | 3 | 33 | |
| GSE60625 | HECW1 | 23072 | 0 | 0 | 11 | |
| GSE74703 | HECW1 | 23072 | 4 | 0 | 32 | |
| GSE74704 | HECW1 | 23072 | 7 | 0 | 13 | |
| TCGA | HECW1 | 23072 | 50 | 7 | 39 |
Total number of gains: 130; Total number of losses: 20; Total Number of normals: 338.
Somatic mutations of HECW1:
Generating mutation plots.
Highly correlated genes for HECW1:
Showing top 20/1103 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HECW1 | ERN1 | 0.823748 | 4 | 0 | 4 |
| HECW1 | ZGLP1 | 0.812642 | 3 | 0 | 3 |
| HECW1 | GRID2 | 0.771527 | 4 | 0 | 4 |
| HECW1 | GPHA2 | 0.770943 | 3 | 0 | 3 |
| HECW1 | FMNL1 | 0.765708 | 3 | 0 | 3 |
| HECW1 | KIR3DL3 | 0.76325 | 6 | 0 | 6 |
| HECW1 | IFNA4 | 0.745155 | 6 | 0 | 6 |
| HECW1 | TNN | 0.74357 | 5 | 0 | 5 |
| HECW1 | KSR1 | 0.732415 | 5 | 0 | 5 |
| HECW1 | TRPM3 | 0.730141 | 5 | 0 | 4 |
| HECW1 | PGC | 0.72644 | 4 | 0 | 3 |
| HECW1 | FXYD7 | 0.726354 | 5 | 0 | 5 |
| HECW1 | TCP10L | 0.723043 | 5 | 0 | 5 |
| HECW1 | SLC6A18 | 0.721424 | 3 | 0 | 3 |
| HECW1 | CYP11B1 | 0.72045 | 7 | 0 | 6 |
| HECW1 | DCC | 0.718035 | 5 | 0 | 5 |
| HECW1 | RNF17 | 0.717835 | 5 | 0 | 5 |
| HECW1 | C19orf44 | 0.716973 | 3 | 0 | 3 |
| HECW1 | UROC1 | 0.716965 | 4 | 0 | 4 |
| HECW1 | LINC01260 | 0.714189 | 5 | 0 | 5 |
For details and further investigation, click here
