| Full name: cholinergic receptor nicotinic beta 3 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p11.21 | ||
| Entrez ID: 1142 | HGNC ID: HGNC:1963 | Ensembl Gene: ENSG00000147432 | OMIM ID: 118508 |
| Drug and gene relationship at DGIdb | |||
Expression of CHRNB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRNB3 | 1142 | 207859_s_at | -0.0058 | 0.9898 | |
| GSE20347 | CHRNB3 | 1142 | 207859_s_at | 0.0029 | 0.9744 | |
| GSE23400 | CHRNB3 | 1142 | 207859_s_at | -0.0648 | 0.0847 | |
| GSE26886 | CHRNB3 | 1142 | 207859_s_at | -0.0501 | 0.6171 | |
| GSE29001 | CHRNB3 | 1142 | 207859_s_at | -0.1525 | 0.2956 | |
| GSE38129 | CHRNB3 | 1142 | 207859_s_at | -0.0542 | 0.4103 | |
| GSE45670 | CHRNB3 | 1142 | 217086_at | -0.0663 | 0.4886 | |
| GSE53622 | CHRNB3 | 1142 | 55609 | 0.6475 | 0.0001 | |
| GSE53624 | CHRNB3 | 1142 | 55609 | 0.0101 | 0.9245 | |
| GSE63941 | CHRNB3 | 1142 | 207859_s_at | -0.1029 | 0.4101 | |
| GSE77861 | CHRNB3 | 1142 | 207859_s_at | -0.0906 | 0.3050 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHRNB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRNB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRNB3 | 1142 | 9 | 5 | 16 | |
| GSE20123 | CHRNB3 | 1142 | 9 | 5 | 16 | |
| GSE43470 | CHRNB3 | 1142 | 9 | 6 | 28 | |
| GSE46452 | CHRNB3 | 1142 | 19 | 5 | 35 | |
| GSE47630 | CHRNB3 | 1142 | 22 | 1 | 17 | |
| GSE54993 | CHRNB3 | 1142 | 1 | 16 | 53 | |
| GSE54994 | CHRNB3 | 1142 | 19 | 7 | 27 | |
| GSE60625 | CHRNB3 | 1142 | 3 | 0 | 8 | |
| GSE74703 | CHRNB3 | 1142 | 8 | 5 | 23 | |
| GSE74704 | CHRNB3 | 1142 | 8 | 2 | 10 | |
| TCGA | CHRNB3 | 1142 | 39 | 21 | 36 |
Total number of gains: 146; Total number of losses: 73; Total Number of normals: 269.
Somatic mutations of CHRNB3:
Generating mutation plots.
Highly correlated genes for CHRNB3:
Showing top 20/276 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRNB3 | KRT76 | 0.697625 | 4 | 0 | 4 |
| CHRNB3 | MLNR | 0.692397 | 3 | 0 | 3 |
| CHRNB3 | GNG13 | 0.68465 | 4 | 0 | 4 |
| CHRNB3 | PRKCQ | 0.676356 | 3 | 0 | 3 |
| CHRNB3 | PRSS50 | 0.672178 | 3 | 0 | 3 |
| CHRNB3 | CAV3 | 0.669209 | 3 | 0 | 3 |
| CHRNB3 | SERPINC1 | 0.664184 | 3 | 0 | 3 |
| CHRNB3 | NTNG1 | 0.664061 | 4 | 0 | 4 |
| CHRNB3 | ATG10 | 0.660009 | 4 | 0 | 4 |
| CHRNB3 | HS3ST3B1 | 0.657744 | 3 | 0 | 3 |
| CHRNB3 | SLC17A3 | 0.65603 | 3 | 0 | 3 |
| CHRNB3 | CYSLTR2 | 0.655957 | 4 | 0 | 4 |
| CHRNB3 | MTAP | 0.653157 | 4 | 0 | 4 |
| CHRNB3 | DNTT | 0.653086 | 3 | 0 | 3 |
| CHRNB3 | B3GALT1 | 0.652278 | 3 | 0 | 3 |
| CHRNB3 | ACR | 0.651758 | 3 | 0 | 3 |
| CHRNB3 | ART4 | 0.650333 | 4 | 0 | 3 |
| CHRNB3 | RFPL2 | 0.648696 | 4 | 0 | 4 |
| CHRNB3 | FAM13C | 0.648058 | 3 | 0 | 3 |
| CHRNB3 | RPS6KA6 | 0.646579 | 5 | 0 | 3 |
For details and further investigation, click here
