IFNA21

 

Full name: interferon alpha 21 Alias Symbol: IFN-alphaI
Type: protein-coding gene Cytoband: 9p21.3
Entrez ID: 3452 HGNC ID: HGNC:5424 Ensembl Gene: ENSG00000137080 OMIM ID: 147584
Drug and gene relationship at DGIdb

 

IFNA21 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles

 

Expression of IFNA21:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IFNA21 3452 211145_x_at -0.4262 0.1636
GSE20347 IFNA21 3452 211145_x_at -0.0706 0.4691
GSE23400 IFNA21 3452 211145_x_at -0.2811 0.0000
GSE26886 IFNA21 3452 211145_x_at -0.2752 0.0195
GSE29001 IFNA21 3452 211145_x_at -0.2867 0.0543
GSE38129 IFNA21 3452 211145_x_at -0.1986 0.0166
GSE45670 IFNA21 3452 211145_x_at -0.0499 0.6031
GSE53622 IFNA21 3452 75295 0.0091 0.9568
GSE53624 IFNA21 3452 75295 0.3172 0.0030
GSE63941 IFNA21 3452 211145_x_at 0.1592 0.3368
GSE77861 IFNA21 3452 211145_x_at -0.1459 0.2455

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IFNA21 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IFNA21:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IFNA21 3452 2 17 11
GSE20123 IFNA21 3452 2 17 11
GSE43470 IFNA21 3452 4 13 26
GSE46452 IFNA21 3452 2 23 34
GSE47630 IFNA21 3452 3 27 10
GSE54993 IFNA21 3452 7 2 61
GSE54994 IFNA21 3452 8 16 29
GSE60625 IFNA21 3452 3 0 8
GSE74703 IFNA21 3452 4 10 22
GSE74704 IFNA21 3452 0 13 7
TCGA IFNA21 3452 11 53 32

Total number of gains: 46; Total number of losses: 191; Total Number of normals: 251.  

 

Somatic mutations of IFNA21:

 

Generating mutation plots.

 

Highly correlated genes for IFNA21:

 

Showing top 20/1037 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IFNA21CYP2D60.754882404
IFNA21IHH0.743558404
IFNA21RALYL0.738035303
IFNA21SH2D3C0.730672404
IFNA21IL17A0.73066505
IFNA21INO80D0.725059404
IFNA21NPAP10.713947404
IFNA21KRT20.710338707
IFNA21KLF150.709452606
IFNA21CER10.708963505
IFNA21GAD20.705383606
IFNA21KRT760.703793505
IFNA21P2RX60.702051504
IFNA21HAL0.697605404
IFNA21ADAMTS80.697165404
IFNA21OR12D20.69696404
IFNA21PIWIL20.696211505
IFNA21TNFSF110.695407404
IFNA21NOS10.695199403
IFNA21UTF10.694854303

For details and further investigation, click here