| Full name: glutamic-oxaloacetic transaminase 2 | Alias Symbol: mitAAT|KATIV|KAT4|KYAT4 | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 2806 | HGNC ID: HGNC:4433 | Ensembl Gene: ENSG00000125166 | OMIM ID: 138150 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GOT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GOT2 | 2806 | 200708_at | 0.2355 | 0.4664 | |
| GSE20347 | GOT2 | 2806 | 200708_at | 0.3006 | 0.0304 | |
| GSE23400 | GOT2 | 2806 | 200708_at | 0.0709 | 0.2378 | |
| GSE26886 | GOT2 | 2806 | 200708_at | -0.2124 | 0.2280 | |
| GSE29001 | GOT2 | 2806 | 200708_at | -0.0188 | 0.9395 | |
| GSE38129 | GOT2 | 2806 | 200708_at | 0.3089 | 0.0398 | |
| GSE45670 | GOT2 | 2806 | 200708_at | 0.3687 | 0.0175 | |
| GSE53622 | GOT2 | 2806 | 65951 | 0.0851 | 0.2173 | |
| GSE53624 | GOT2 | 2806 | 65951 | 0.3854 | 0.0000 | |
| GSE63941 | GOT2 | 2806 | 200708_at | 1.1587 | 0.0103 | |
| GSE77861 | GOT2 | 2806 | 200708_at | 0.2857 | 0.2901 | |
| GSE97050 | GOT2 | 2806 | A_33_P3414482 | -0.0743 | 0.7928 | |
| SRP007169 | GOT2 | 2806 | RNAseq | 0.0350 | 0.9300 | |
| SRP008496 | GOT2 | 2806 | RNAseq | -0.5418 | 0.0831 | |
| SRP064894 | GOT2 | 2806 | RNAseq | -0.0813 | 0.6229 | |
| SRP133303 | GOT2 | 2806 | RNAseq | 0.5099 | 0.0240 | |
| SRP159526 | GOT2 | 2806 | RNAseq | 0.2269 | 0.2394 | |
| SRP193095 | GOT2 | 2806 | RNAseq | 0.1081 | 0.4452 | |
| SRP219564 | GOT2 | 2806 | RNAseq | -0.0902 | 0.7516 | |
| TCGA | GOT2 | 2806 | RNAseq | 0.0335 | 0.4805 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GOT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GOT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GOT2 | 2806 | 6 | 0 | 24 | |
| GSE20123 | GOT2 | 2806 | 6 | 0 | 24 | |
| GSE43470 | GOT2 | 2806 | 2 | 7 | 34 | |
| GSE46452 | GOT2 | 2806 | 38 | 1 | 20 | |
| GSE47630 | GOT2 | 2806 | 10 | 8 | 22 | |
| GSE54993 | GOT2 | 2806 | 2 | 4 | 64 | |
| GSE54994 | GOT2 | 2806 | 6 | 10 | 37 | |
| GSE60625 | GOT2 | 2806 | 4 | 0 | 7 | |
| GSE74703 | GOT2 | 2806 | 2 | 5 | 29 | |
| GSE74704 | GOT2 | 2806 | 5 | 0 | 15 | |
| TCGA | GOT2 | 2806 | 26 | 11 | 59 |
Total number of gains: 107; Total number of losses: 46; Total Number of normals: 335.
Somatic mutations of GOT2:
Generating mutation plots.
Highly correlated genes for GOT2:
Showing top 20/559 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GOT2 | DDB1 | 0.825613 | 3 | 0 | 3 |
| GOT2 | ACO2 | 0.809193 | 3 | 0 | 3 |
| GOT2 | MRPL38 | 0.761529 | 4 | 0 | 4 |
| GOT2 | SPG21 | 0.749809 | 3 | 0 | 3 |
| GOT2 | HNRNPM | 0.744953 | 3 | 0 | 3 |
| GOT2 | ARMC10 | 0.743924 | 4 | 0 | 4 |
| GOT2 | PSMD5 | 0.738928 | 3 | 0 | 3 |
| GOT2 | RNF26 | 0.731434 | 3 | 0 | 3 |
| GOT2 | ZNF484 | 0.714816 | 3 | 0 | 3 |
| GOT2 | DEXI | 0.712772 | 4 | 0 | 4 |
| GOT2 | ZNF764 | 0.706282 | 3 | 0 | 3 |
| GOT2 | CWF19L1 | 0.704159 | 3 | 0 | 3 |
| GOT2 | DAG1 | 0.702788 | 3 | 0 | 3 |
| GOT2 | IRF2BPL | 0.693544 | 4 | 0 | 3 |
| GOT2 | LCLAT1 | 0.692661 | 4 | 0 | 3 |
| GOT2 | MAT2B | 0.690201 | 3 | 0 | 3 |
| GOT2 | RHBDD1 | 0.68385 | 3 | 0 | 3 |
| GOT2 | TWISTNB | 0.682807 | 3 | 0 | 3 |
| GOT2 | DNAJC19 | 0.680185 | 3 | 0 | 3 |
| GOT2 | CD86 | 0.679475 | 3 | 0 | 3 |
For details and further investigation, click here
