| Full name: CD86 molecule | Alias Symbol: B7.2|B7-2 | ||
| Type: protein-coding gene | Cytoband: 3q13.33 | ||
| Entrez ID: 942 | HGNC ID: HGNC:1705 | Ensembl Gene: ENSG00000114013 | OMIM ID: 601020 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CD86 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04620 | Toll-like receptor signaling pathway |
Expression of CD86:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD86 | 942 | 210895_s_at | 0.8087 | 0.3972 | |
| GSE20347 | CD86 | 942 | 210895_s_at | 0.2579 | 0.2070 | |
| GSE23400 | CD86 | 942 | 210895_s_at | 0.3417 | 0.0000 | |
| GSE26886 | CD86 | 942 | 205685_at | 0.3134 | 0.0626 | |
| GSE29001 | CD86 | 942 | 205686_s_at | 0.7047 | 0.0425 | |
| GSE38129 | CD86 | 942 | 210895_s_at | 0.6504 | 0.0105 | |
| GSE45670 | CD86 | 942 | 205685_at | 0.2395 | 0.0906 | |
| GSE63941 | CD86 | 942 | 210895_s_at | 0.5376 | 0.2585 | |
| GSE77861 | CD86 | 942 | 205685_at | 0.1034 | 0.3727 | |
| GSE97050 | CD86 | 942 | A_24_P131589 | 0.2635 | 0.2878 | |
| SRP007169 | CD86 | 942 | RNAseq | 1.2716 | 0.0320 | |
| SRP008496 | CD86 | 942 | RNAseq | 1.3939 | 0.0005 | |
| SRP064894 | CD86 | 942 | RNAseq | 1.1613 | 0.0000 | |
| SRP133303 | CD86 | 942 | RNAseq | 1.1488 | 0.0001 | |
| SRP159526 | CD86 | 942 | RNAseq | 0.3282 | 0.6640 | |
| SRP193095 | CD86 | 942 | RNAseq | 0.8602 | 0.0000 | |
| SRP219564 | CD86 | 942 | RNAseq | 1.8984 | 0.0030 | |
| TCGA | CD86 | 942 | RNAseq | 0.8703 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by CD86 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CD86:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD86 | 942 | 18 | 0 | 12 | |
| GSE20123 | CD86 | 942 | 18 | 0 | 12 | |
| GSE43470 | CD86 | 942 | 20 | 0 | 23 | |
| GSE46452 | CD86 | 942 | 14 | 5 | 40 | |
| GSE47630 | CD86 | 942 | 16 | 5 | 19 | |
| GSE54993 | CD86 | 942 | 2 | 6 | 62 | |
| GSE54994 | CD86 | 942 | 30 | 4 | 19 | |
| GSE60625 | CD86 | 942 | 0 | 6 | 5 | |
| GSE74703 | CD86 | 942 | 16 | 0 | 20 | |
| GSE74704 | CD86 | 942 | 13 | 0 | 7 | |
| TCGA | CD86 | 942 | 54 | 6 | 36 |
Total number of gains: 201; Total number of losses: 32; Total Number of normals: 255.
Somatic mutations of CD86:
Generating mutation plots.
Highly correlated genes for CD86:
Showing top 20/444 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD86 | TFEC | 0.778472 | 7 | 0 | 7 |
| CD86 | MEX3C | 0.758294 | 3 | 0 | 3 |
| CD86 | RGS18 | 0.747463 | 3 | 0 | 3 |
| CD86 | CLEC12A | 0.743045 | 3 | 0 | 3 |
| CD86 | TSPAN9 | 0.725384 | 3 | 0 | 3 |
| CD86 | SERPINA1 | 0.718582 | 8 | 0 | 7 |
| CD86 | ITGB2 | 0.714378 | 8 | 0 | 7 |
| CD86 | CD1D | 0.709147 | 3 | 0 | 3 |
| CD86 | HAVCR2 | 0.70881 | 5 | 0 | 4 |
| CD86 | MNDA | 0.708758 | 8 | 0 | 6 |
| CD86 | PRPSAP2 | 0.708092 | 3 | 0 | 3 |
| CD86 | ALOX5AP | 0.707965 | 5 | 0 | 5 |
| CD86 | NEK6 | 0.706847 | 4 | 0 | 3 |
| CD86 | ADAMDEC1 | 0.706048 | 8 | 0 | 7 |
| CD86 | CD300A | 0.698285 | 9 | 0 | 9 |
| CD86 | EVI2A | 0.698147 | 6 | 0 | 6 |
| CD86 | CD53 | 0.69787 | 9 | 0 | 7 |
| CD86 | NOSIP | 0.694991 | 4 | 0 | 4 |
| CD86 | SH3PXD2B | 0.689556 | 4 | 0 | 4 |
| CD86 | SAMSN1 | 0.688623 | 9 | 0 | 7 |
For details and further investigation, click here
