| Full name: SPG21 abhydrolase domain containing, maspardin | Alias Symbol: ACP33|GL010|BM-019|MAST|ABHD21 | ||
| Type: protein-coding gene | Cytoband: 15q22.31 | ||
| Entrez ID: 51324 | HGNC ID: HGNC:20373 | Ensembl Gene: ENSG00000090487 | OMIM ID: 608181 |
| Drug and gene relationship at DGIdb | |||
Expression of SPG21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPG21 | 51324 | 217827_s_at | 0.3945 | 0.3411 | |
| GSE20347 | SPG21 | 51324 | 217827_s_at | 0.4481 | 0.0100 | |
| GSE23400 | SPG21 | 51324 | 217827_s_at | 0.5322 | 0.0000 | |
| GSE26886 | SPG21 | 51324 | 217827_s_at | -0.3937 | 0.1131 | |
| GSE29001 | SPG21 | 51324 | 217827_s_at | 0.4364 | 0.0933 | |
| GSE38129 | SPG21 | 51324 | 217827_s_at | 0.4704 | 0.0015 | |
| GSE45670 | SPG21 | 51324 | 217827_s_at | 0.1474 | 0.2155 | |
| GSE53622 | SPG21 | 51324 | 89053 | 0.4932 | 0.0000 | |
| GSE53624 | SPG21 | 51324 | 89053 | 0.5765 | 0.0000 | |
| GSE63941 | SPG21 | 51324 | 217827_s_at | -0.3042 | 0.4068 | |
| GSE77861 | SPG21 | 51324 | 217827_s_at | 0.5299 | 0.0299 | |
| GSE97050 | SPG21 | 51324 | A_23_P147450 | 0.2947 | 0.2028 | |
| SRP007169 | SPG21 | 51324 | RNAseq | 0.3846 | 0.2359 | |
| SRP008496 | SPG21 | 51324 | RNAseq | 0.6166 | 0.0166 | |
| SRP064894 | SPG21 | 51324 | RNAseq | 0.4580 | 0.0012 | |
| SRP133303 | SPG21 | 51324 | RNAseq | 0.2332 | 0.0096 | |
| SRP159526 | SPG21 | 51324 | RNAseq | 0.4467 | 0.1891 | |
| SRP193095 | SPG21 | 51324 | RNAseq | 0.1354 | 0.1223 | |
| SRP219564 | SPG21 | 51324 | RNAseq | 0.2982 | 0.2788 | |
| TCGA | SPG21 | 51324 | RNAseq | 0.1106 | 0.0176 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPG21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPG21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPG21 | 51324 | 7 | 3 | 20 | |
| GSE20123 | SPG21 | 51324 | 7 | 3 | 20 | |
| GSE43470 | SPG21 | 51324 | 4 | 6 | 33 | |
| GSE46452 | SPG21 | 51324 | 3 | 7 | 49 | |
| GSE47630 | SPG21 | 51324 | 8 | 10 | 22 | |
| GSE54993 | SPG21 | 51324 | 5 | 6 | 59 | |
| GSE54994 | SPG21 | 51324 | 6 | 7 | 40 | |
| GSE60625 | SPG21 | 51324 | 4 | 0 | 7 | |
| GSE74703 | SPG21 | 51324 | 4 | 3 | 29 | |
| GSE74704 | SPG21 | 51324 | 3 | 3 | 14 | |
| TCGA | SPG21 | 51324 | 10 | 16 | 70 |
Total number of gains: 61; Total number of losses: 64; Total Number of normals: 363.
Somatic mutations of SPG21:
Generating mutation plots.
Highly correlated genes for SPG21:
Showing top 20/1248 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPG21 | FAM89A | 0.761909 | 3 | 0 | 3 |
| SPG21 | GOT2 | 0.749809 | 3 | 0 | 3 |
| SPG21 | ZNF641 | 0.749592 | 3 | 0 | 3 |
| SPG21 | ZNF668 | 0.748189 | 4 | 0 | 4 |
| SPG21 | SMARCAD1 | 0.747657 | 3 | 0 | 3 |
| SPG21 | RAVER1 | 0.747348 | 3 | 0 | 3 |
| SPG21 | KLHL5 | 0.717937 | 4 | 0 | 3 |
| SPG21 | MRPL38 | 0.713961 | 4 | 0 | 3 |
| SPG21 | GRAMD1A | 0.707143 | 4 | 0 | 4 |
| SPG21 | CDK4 | 0.704885 | 10 | 0 | 9 |
| SPG21 | RANBP1 | 0.704837 | 9 | 0 | 9 |
| SPG21 | RCN2 | 0.701996 | 10 | 0 | 9 |
| SPG21 | DYRK2 | 0.701121 | 4 | 0 | 3 |
| SPG21 | CCT4 | 0.700702 | 10 | 0 | 9 |
| SPG21 | LSM2 | 0.700249 | 10 | 0 | 8 |
| SPG21 | SLC43A2 | 0.693827 | 3 | 0 | 3 |
| SPG21 | ELAVL1 | 0.692762 | 10 | 0 | 8 |
| SPG21 | ZMYM6 | 0.690863 | 5 | 0 | 5 |
| SPG21 | GNG10 | 0.69073 | 4 | 0 | 4 |
| SPG21 | MRPS12 | 0.690038 | 8 | 0 | 8 |
For details and further investigation, click here
