| Full name: aconitase 2 | Alias Symbol: ACONM | ||
| Type: protein-coding gene | Cytoband: 22q13.2 | ||
| Entrez ID: 50 | HGNC ID: HGNC:118 | Ensembl Gene: ENSG00000100412 | OMIM ID: 100850 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ACO2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACO2 | 50 | 200793_s_at | -0.1037 | 0.8213 | |
| GSE20347 | ACO2 | 50 | 200793_s_at | -0.0972 | 0.5456 | |
| GSE23400 | ACO2 | 50 | 200793_s_at | -0.1594 | 0.0136 | |
| GSE26886 | ACO2 | 50 | 200793_s_at | -0.4922 | 0.0428 | |
| GSE29001 | ACO2 | 50 | 200793_s_at | -0.0890 | 0.7470 | |
| GSE38129 | ACO2 | 50 | 200793_s_at | -0.2508 | 0.0616 | |
| GSE45670 | ACO2 | 50 | 200793_s_at | 0.0481 | 0.8438 | |
| GSE63941 | ACO2 | 50 | 200793_s_at | 1.0799 | 0.0372 | |
| GSE77861 | ACO2 | 50 | 200793_s_at | 0.2902 | 0.3020 | |
| GSE97050 | ACO2 | 50 | A_23_P103149 | -0.4247 | 0.3134 | |
| SRP007169 | ACO2 | 50 | RNAseq | 0.5136 | 0.1304 | |
| SRP008496 | ACO2 | 50 | RNAseq | -0.1561 | 0.5609 | |
| SRP064894 | ACO2 | 50 | RNAseq | 0.1280 | 0.3501 | |
| SRP133303 | ACO2 | 50 | RNAseq | 0.1128 | 0.4470 | |
| SRP159526 | ACO2 | 50 | RNAseq | 0.2910 | 0.2191 | |
| SRP193095 | ACO2 | 50 | RNAseq | -0.1987 | 0.1752 | |
| SRP219564 | ACO2 | 50 | RNAseq | -0.2650 | 0.6284 | |
| TCGA | ACO2 | 50 | RNAseq | -0.2927 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ACO2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ACO2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACO2 | 50 | 6 | 5 | 19 | |
| GSE20123 | ACO2 | 50 | 6 | 4 | 20 | |
| GSE43470 | ACO2 | 50 | 5 | 6 | 32 | |
| GSE46452 | ACO2 | 50 | 31 | 2 | 26 | |
| GSE47630 | ACO2 | 50 | 9 | 4 | 27 | |
| GSE54993 | ACO2 | 50 | 3 | 6 | 61 | |
| GSE54994 | ACO2 | 50 | 11 | 8 | 34 | |
| GSE60625 | ACO2 | 50 | 5 | 0 | 6 | |
| GSE74703 | ACO2 | 50 | 5 | 4 | 27 | |
| GSE74704 | ACO2 | 50 | 3 | 2 | 15 | |
| TCGA | ACO2 | 50 | 27 | 14 | 55 |
Total number of gains: 111; Total number of losses: 55; Total Number of normals: 322.
Somatic mutations of ACO2:
Generating mutation plots.
Highly correlated genes for ACO2:
Showing top 20/374 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACO2 | GOT2 | 0.809193 | 3 | 0 | 3 |
| ACO2 | ACRBP | 0.798514 | 3 | 0 | 3 |
| ACO2 | CREB3 | 0.778903 | 3 | 0 | 3 |
| ACO2 | CDC37 | 0.751838 | 3 | 0 | 3 |
| ACO2 | VPS28 | 0.747799 | 3 | 0 | 3 |
| ACO2 | ZNF664 | 0.743642 | 3 | 0 | 3 |
| ACO2 | DHX38 | 0.723494 | 3 | 0 | 3 |
| ACO2 | ADNP2 | 0.723045 | 3 | 0 | 3 |
| ACO2 | SMO | 0.718417 | 3 | 0 | 3 |
| ACO2 | PTPN9 | 0.713054 | 3 | 0 | 3 |
| ACO2 | PNKD | 0.712935 | 3 | 0 | 3 |
| ACO2 | RBM4B | 0.709485 | 3 | 0 | 3 |
| ACO2 | TSFM | 0.708564 | 3 | 0 | 3 |
| ACO2 | NKX6-1 | 0.705815 | 4 | 0 | 3 |
| ACO2 | TOMM22 | 0.703972 | 6 | 0 | 5 |
| ACO2 | UBL5 | 0.699779 | 3 | 0 | 3 |
| ACO2 | CYB5B | 0.698263 | 3 | 0 | 3 |
| ACO2 | KIAA1257 | 0.697195 | 3 | 0 | 3 |
| ACO2 | DCTD | 0.695736 | 3 | 0 | 3 |
| ACO2 | CKMT2 | 0.692461 | 4 | 0 | 3 |
For details and further investigation, click here
