GRB10

 

Full name: growth factor receptor bound protein 10 Alias Symbol: 
Type: protein-coding gene Cytoband: 7p12.1
Entrez ID: 2887 HGNC ID: HGNC:4564 Ensembl Gene: ENSG00000106070 OMIM ID: 601523
Drug and gene relationship at DGIdb

 

GRB10 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway

 

Expression of GRB10:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GRB10 2887 209409_at -0.0714 0.9438
GSE20347 GRB10 2887 209409_at 1.1688 0.0001
GSE23400 GRB10 2887 209409_at 0.7406 0.0000
GSE26886 GRB10 2887 209409_at 1.5453 0.0000
GSE29001 GRB10 2887 209409_at 0.4807 0.2336
GSE38129 GRB10 2887 209409_at 0.9608 0.0002
GSE45670 GRB10 2887 209409_at 0.3774 0.2329
GSE53622 GRB10 2887 44559 0.4166 0.0010
GSE53624 GRB10 2887 44559 0.8467 0.0000
GSE63941 GRB10 2887 209409_at -0.6458 0.7721
GSE77861 GRB10 2887 209409_at 1.4968 0.0137
GSE97050 GRB10 2887 A_23_P122863 0.7626 0.2491
SRP007169 GRB10 2887 RNAseq 3.0238 0.0000
SRP008496 GRB10 2887 RNAseq 2.9566 0.0000
SRP064894 GRB10 2887 RNAseq 0.9603 0.0000
SRP133303 GRB10 2887 RNAseq 1.1263 0.0000
SRP159526 GRB10 2887 RNAseq 1.2726 0.0024
SRP193095 GRB10 2887 RNAseq 1.1993 0.0000
SRP219564 GRB10 2887 RNAseq 0.5634 0.1521
TCGA GRB10 2887 RNAseq -0.0705 0.4106

Upregulated datasets: 8; Downregulated datasets: 0.  

 

Survival by GRB10 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GRB10:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GRB10 2887 12 0 18
GSE20123 GRB10 2887 11 0 19
GSE43470 GRB10 2887 4 1 38
GSE46452 GRB10 2887 11 1 47
GSE47630 GRB10 2887 8 1 31
GSE54993 GRB10 2887 0 8 62
GSE54994 GRB10 2887 18 2 33
GSE60625 GRB10 2887 0 0 11
GSE74703 GRB10 2887 4 1 31
GSE74704 GRB10 2887 5 0 15
TCGA GRB10 2887 48 10 38

Total number of gains: 121; Total number of losses: 24; Total Number of normals: 343.  

 

Somatic mutations of GRB10:

 

Generating mutation plots.

 

Highly correlated genes for GRB10:

 

Showing top 20/1320 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GRB10DNM1L0.763553303
GRB10RILPL10.763355303
GRB10SEC22C0.761916404
GRB10SPIRE10.734964403
GRB10SGTB0.734071404
GRB10DOCK110.73058504
GRB10TAOK10.728169303
GRB10PDE7A0.72034403
GRB10SCCPDH0.70827410010
GRB10TNFAIP10.706282303
GRB10FADS10.705074303
GRB10DNAJC180.704576303
GRB10CEP2900.704231808
GRB10ERRFI10.69549303
GRB10WDR810.693628404
GRB10CENPV0.6936605
GRB10PRTFDC10.693066706
GRB10CNTD10.692984303
GRB10LAMB10.69264510010
GRB10PXDN0.6925911011

For details and further investigation, click here