| Full name: spire type actin nucleation factor 1 | Alias Symbol: spir-1|KIAA1135 | ||
| Type: protein-coding gene | Cytoband: 18p11.21 | ||
| Entrez ID: 56907 | HGNC ID: HGNC:30622 | Ensembl Gene: ENSG00000134278 | OMIM ID: 609216 |
| Drug and gene relationship at DGIdb | |||
Expression of SPIRE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPIRE1 | 56907 | 224995_at | 0.0996 | 0.9255 | |
| GSE26886 | SPIRE1 | 56907 | 224995_at | 1.4627 | 0.0000 | |
| GSE45670 | SPIRE1 | 56907 | 224995_at | 0.2629 | 0.3950 | |
| GSE53622 | SPIRE1 | 56907 | 25259 | 0.3497 | 0.0038 | |
| GSE53624 | SPIRE1 | 56907 | 25259 | 0.5335 | 0.0000 | |
| GSE63941 | SPIRE1 | 56907 | 224995_at | -0.1506 | 0.8380 | |
| GSE77861 | SPIRE1 | 56907 | 224995_at | 0.5140 | 0.0276 | |
| GSE97050 | SPIRE1 | 56907 | A_33_P3301010 | 0.1164 | 0.8355 | |
| SRP007169 | SPIRE1 | 56907 | RNAseq | 0.8684 | 0.1928 | |
| SRP008496 | SPIRE1 | 56907 | RNAseq | 0.1259 | 0.7881 | |
| SRP064894 | SPIRE1 | 56907 | RNAseq | 0.5518 | 0.0216 | |
| SRP133303 | SPIRE1 | 56907 | RNAseq | 0.8439 | 0.0004 | |
| SRP159526 | SPIRE1 | 56907 | RNAseq | 1.1830 | 0.0092 | |
| SRP193095 | SPIRE1 | 56907 | RNAseq | 0.4273 | 0.0647 | |
| SRP219564 | SPIRE1 | 56907 | RNAseq | 0.1710 | 0.6730 | |
| TCGA | SPIRE1 | 56907 | RNAseq | -0.1273 | 0.1136 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SPIRE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPIRE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPIRE1 | 56907 | 5 | 3 | 22 | |
| GSE20123 | SPIRE1 | 56907 | 5 | 3 | 22 | |
| GSE43470 | SPIRE1 | 56907 | 0 | 6 | 37 | |
| GSE46452 | SPIRE1 | 56907 | 3 | 21 | 35 | |
| GSE47630 | SPIRE1 | 56907 | 7 | 17 | 16 | |
| GSE54993 | SPIRE1 | 56907 | 6 | 2 | 62 | |
| GSE54994 | SPIRE1 | 56907 | 8 | 8 | 37 | |
| GSE60625 | SPIRE1 | 56907 | 0 | 4 | 7 | |
| GSE74703 | SPIRE1 | 56907 | 0 | 4 | 32 | |
| GSE74704 | SPIRE1 | 56907 | 3 | 2 | 15 | |
| TCGA | SPIRE1 | 56907 | 29 | 23 | 44 |
Total number of gains: 66; Total number of losses: 93; Total Number of normals: 329.
Somatic mutations of SPIRE1:
Generating mutation plots.
Highly correlated genes for SPIRE1:
Showing top 20/670 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPIRE1 | XYLT2 | 0.805952 | 3 | 0 | 3 |
| SPIRE1 | TP53I13 | 0.798978 | 3 | 0 | 3 |
| SPIRE1 | SF3B2 | 0.798798 | 3 | 0 | 3 |
| SPIRE1 | ADCY3 | 0.797875 | 3 | 0 | 3 |
| SPIRE1 | DNAJC2 | 0.794042 | 3 | 0 | 3 |
| SPIRE1 | U2SURP | 0.785165 | 3 | 0 | 3 |
| SPIRE1 | BRI3 | 0.777646 | 3 | 0 | 3 |
| SPIRE1 | SLC38A10 | 0.767998 | 3 | 0 | 3 |
| SPIRE1 | PSMG3 | 0.767637 | 3 | 0 | 3 |
| SPIRE1 | CCM2 | 0.767558 | 3 | 0 | 3 |
| SPIRE1 | RIOK1 | 0.767178 | 3 | 0 | 3 |
| SPIRE1 | BICD2 | 0.762351 | 3 | 0 | 3 |
| SPIRE1 | TRIM47 | 0.757124 | 3 | 0 | 3 |
| SPIRE1 | PKIG | 0.755916 | 3 | 0 | 3 |
| SPIRE1 | YWHAG | 0.755089 | 3 | 0 | 3 |
| SPIRE1 | IMPDH1 | 0.754841 | 3 | 0 | 3 |
| SPIRE1 | OSBPL9 | 0.754494 | 4 | 0 | 4 |
| SPIRE1 | SF3A2 | 0.753897 | 3 | 0 | 3 |
| SPIRE1 | TIGD1 | 0.75211 | 3 | 0 | 3 |
| SPIRE1 | PBXIP1 | 0.751985 | 3 | 0 | 3 |
For details and further investigation, click here
