PXDN

 

Full name: peroxidasin Alias Symbol: KIAA0230|PRG2|MG50|D2S448|D2S448E|PXN
Type: protein-coding gene Cytoband: 2p25.3
Entrez ID: 7837 HGNC ID: HGNC:14966 Ensembl Gene: ENSG00000130508 OMIM ID: 605158
Drug and gene relationship at DGIdb

 

Expression of PXDN:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PXDN 7837 212012_at 0.7573 0.3520
GSE20347 PXDN 7837 212012_at 1.7273 0.0000
GSE23400 PXDN 7837 212012_at 1.3013 0.0000
GSE26886 PXDN 7837 212012_at 3.5818 0.0000
GSE29001 PXDN 7837 212012_at 2.3638 0.0001
GSE38129 PXDN 7837 212012_at 1.6519 0.0001
GSE45670 PXDN 7837 212012_at 1.2177 0.0159
GSE53622 PXDN 7837 58560 1.8865 0.0000
GSE53624 PXDN 7837 58560 2.3493 0.0000
GSE63941 PXDN 7837 212012_at -4.5867 0.0103
GSE77861 PXDN 7837 212012_at 1.2534 0.0069
GSE97050 PXDN 7837 A_33_P3238166 1.1244 0.0620
SRP007169 PXDN 7837 RNAseq 7.0149 0.0000
SRP008496 PXDN 7837 RNAseq 5.9404 0.0000
SRP064894 PXDN 7837 RNAseq 2.4899 0.0000
SRP133303 PXDN 7837 RNAseq 2.1796 0.0000
SRP159526 PXDN 7837 RNAseq 3.1198 0.0000
SRP193095 PXDN 7837 RNAseq 3.1272 0.0000
SRP219564 PXDN 7837 RNAseq 1.0583 0.1102
TCGA PXDN 7837 RNAseq 0.3539 0.0034

Upregulated datasets: 15; Downregulated datasets: 1.  

 

Survival by PXDN expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PXDN:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PXDN 7837 8 3 19
GSE20123 PXDN 7837 8 3 19
GSE43470 PXDN 7837 3 1 39
GSE46452 PXDN 7837 3 4 52
GSE47630 PXDN 7837 7 0 33
GSE54993 PXDN 7837 1 7 62
GSE54994 PXDN 7837 13 0 40
GSE60625 PXDN 7837 0 3 8
GSE74703 PXDN 7837 3 0 33
GSE74704 PXDN 7837 8 1 11
TCGA PXDN 7837 32 5 59

Total number of gains: 86; Total number of losses: 27; Total Number of normals: 375.  

 

Somatic mutations of PXDN:

 

Generating mutation plots.

 

Highly correlated genes for PXDN:

 

Showing top 20/1667 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PXDNWDR540.815851707
PXDNVCAN0.8120413013
PXDNFADS10.805662303
PXDNFCGR3A0.801522303
PXDNCOL4A10.80151913012
PXDNC11orf960.793814303
PXDNTRAM20.79201812011
PXDNCDH110.78667713012
PXDNRAI140.78178712012
PXDNSLC39A140.78096612011
PXDNMMD0.78074313012
PXDNLOXL20.78070512012
PXDNCALU0.78020512012
PXDNGNG100.778051303
PXDNSHISA20.772183606
PXDNNUAK10.770612011
PXDNLPCAT10.77005912012
PXDNPLOD30.76673411011
PXDNCOL5A10.76096513013
PXDNMFAP20.7599812011

For details and further investigation, click here