| Full name: dynamin 1 like | Alias Symbol: DRP1|DVLP|HDYNIV|DYMPLE|VPS1 | ||
| Type: protein-coding gene | Cytoband: 12p11.21 | ||
| Entrez ID: 10059 | HGNC ID: HGNC:2973 | Ensembl Gene: ENSG00000087470 | OMIM ID: 603850 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
DNM1L involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04668 | TNF signaling pathway |
Expression of DNM1L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNM1L | 10059 | 226154_at | -0.0232 | 0.9714 | |
| GSE20347 | DNM1L | 10059 | 203105_s_at | 0.6899 | 0.0178 | |
| GSE23400 | DNM1L | 10059 | 203105_s_at | 0.6271 | 0.0000 | |
| GSE26886 | DNM1L | 10059 | 226154_at | 1.0906 | 0.0000 | |
| GSE29001 | DNM1L | 10059 | 203105_s_at | 0.6906 | 0.0672 | |
| GSE38129 | DNM1L | 10059 | 203105_s_at | 0.7711 | 0.0005 | |
| GSE45670 | DNM1L | 10059 | 226154_at | 0.0499 | 0.7645 | |
| GSE53622 | DNM1L | 10059 | 12511 | 0.2150 | 0.0040 | |
| GSE53624 | DNM1L | 10059 | 12511 | 0.3099 | 0.0010 | |
| GSE63941 | DNM1L | 10059 | 226154_at | 0.4327 | 0.3845 | |
| GSE77861 | DNM1L | 10059 | 226154_at | 0.5937 | 0.0048 | |
| GSE97050 | DNM1L | 10059 | A_23_P204324 | -0.3401 | 0.2001 | |
| SRP007169 | DNM1L | 10059 | RNAseq | 0.2764 | 0.3398 | |
| SRP008496 | DNM1L | 10059 | RNAseq | 0.2573 | 0.1130 | |
| SRP064894 | DNM1L | 10059 | RNAseq | -0.0097 | 0.9550 | |
| SRP133303 | DNM1L | 10059 | RNAseq | 0.4297 | 0.0005 | |
| SRP159526 | DNM1L | 10059 | RNAseq | 0.1531 | 0.2278 | |
| SRP193095 | DNM1L | 10059 | RNAseq | 0.2459 | 0.0419 | |
| SRP219564 | DNM1L | 10059 | RNAseq | -0.2074 | 0.6147 | |
| TCGA | DNM1L | 10059 | RNAseq | 0.1073 | 0.0150 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DNM1L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNM1L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNM1L | 10059 | 10 | 3 | 17 | |
| GSE20123 | DNM1L | 10059 | 10 | 3 | 17 | |
| GSE43470 | DNM1L | 10059 | 7 | 4 | 32 | |
| GSE46452 | DNM1L | 10059 | 10 | 1 | 48 | |
| GSE47630 | DNM1L | 10059 | 12 | 1 | 27 | |
| GSE54993 | DNM1L | 10059 | 0 | 9 | 61 | |
| GSE54994 | DNM1L | 10059 | 8 | 2 | 43 | |
| GSE60625 | DNM1L | 10059 | 0 | 1 | 10 | |
| GSE74703 | DNM1L | 10059 | 7 | 3 | 26 | |
| GSE74704 | DNM1L | 10059 | 6 | 1 | 13 | |
| TCGA | DNM1L | 10059 | 39 | 5 | 52 |
Total number of gains: 109; Total number of losses: 33; Total Number of normals: 346.
Somatic mutations of DNM1L:
Generating mutation plots.
Highly correlated genes for DNM1L:
Showing top 20/1024 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNM1L | RILPL2 | 0.804629 | 3 | 0 | 3 |
| DNM1L | PKIG | 0.79036 | 3 | 0 | 3 |
| DNM1L | TRAF5 | 0.783906 | 3 | 0 | 3 |
| DNM1L | NEDD9 | 0.781518 | 3 | 0 | 3 |
| DNM1L | GRB10 | 0.763553 | 3 | 0 | 3 |
| DNM1L | FMNL2 | 0.753192 | 3 | 0 | 3 |
| DNM1L | DYNC2LI1 | 0.752835 | 4 | 0 | 4 |
| DNM1L | DLG5 | 0.746864 | 3 | 0 | 3 |
| DNM1L | BCL7B | 0.743207 | 3 | 0 | 3 |
| DNM1L | LARP6 | 0.741754 | 4 | 0 | 3 |
| DNM1L | SPOPL | 0.739157 | 3 | 0 | 3 |
| DNM1L | WDR35 | 0.737432 | 3 | 0 | 3 |
| DNM1L | INSR | 0.736399 | 4 | 0 | 3 |
| DNM1L | RNASEH2C | 0.736213 | 3 | 0 | 3 |
| DNM1L | RTTN | 0.735455 | 3 | 0 | 3 |
| DNM1L | TMEM181 | 0.734108 | 3 | 0 | 3 |
| DNM1L | HMCN1 | 0.729772 | 3 | 0 | 3 |
| DNM1L | FILIP1 | 0.72855 | 3 | 0 | 3 |
| DNM1L | SLC41A1 | 0.726879 | 4 | 0 | 3 |
| DNM1L | DPYSL2 | 0.721394 | 3 | 0 | 3 |
For details and further investigation, click here
