| Full name: toll like receptor 8 | Alias Symbol: CD288 | ||
| Type: protein-coding gene | Cytoband: Xp22.2 | ||
| Entrez ID: 51311 | HGNC ID: HGNC:15632 | Ensembl Gene: ENSG00000101916 | OMIM ID: 300366 |
| Drug and gene relationship at DGIdb | |||
TLR8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04620 | Toll-like receptor signaling pathway |
Expression of TLR8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLR8 | 51311 | 229560_at | 0.8054 | 0.5851 | |
| GSE20347 | TLR8 | 51311 | 220832_at | -0.2295 | 0.0002 | |
| GSE23400 | TLR8 | 51311 | 220832_at | -0.1497 | 0.0000 | |
| GSE26886 | TLR8 | 51311 | 229560_at | 0.0268 | 0.9549 | |
| GSE29001 | TLR8 | 51311 | 220832_at | -0.2886 | 0.0723 | |
| GSE38129 | TLR8 | 51311 | 220832_at | -0.1683 | 0.0027 | |
| GSE45670 | TLR8 | 51311 | 229560_at | 0.3963 | 0.3081 | |
| GSE53622 | TLR8 | 51311 | 107520 | 0.5945 | 0.0058 | |
| GSE53624 | TLR8 | 51311 | 107520 | 0.9098 | 0.0013 | |
| GSE63941 | TLR8 | 51311 | 220832_at | -0.0081 | 0.9636 | |
| GSE77861 | TLR8 | 51311 | 220832_at | -0.1695 | 0.2132 | |
| GSE97050 | TLR8 | 51311 | A_23_P73837 | 0.6415 | 0.3026 | |
| SRP007169 | TLR8 | 51311 | RNAseq | 3.8180 | 0.0009 | |
| SRP133303 | TLR8 | 51311 | RNAseq | 0.8730 | 0.0314 | |
| SRP193095 | TLR8 | 51311 | RNAseq | 1.0605 | 0.0000 | |
| SRP219564 | TLR8 | 51311 | RNAseq | 1.5319 | 0.0161 | |
| TCGA | TLR8 | 51311 | RNAseq | 0.5273 | 0.0745 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by TLR8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLR8:
No record found for this gene.
Somatic mutations of TLR8:
Generating mutation plots.
Highly correlated genes for TLR8:
Showing top 20/325 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLR8 | GRIN1 | 0.748158 | 3 | 0 | 3 |
| TLR8 | AMHR2 | 0.740892 | 3 | 0 | 3 |
| TLR8 | KCNMB2 | 0.726532 | 3 | 0 | 3 |
| TLR8 | PRODH2 | 0.725873 | 3 | 0 | 3 |
| TLR8 | SPTBN5 | 0.722592 | 3 | 0 | 3 |
| TLR8 | FPR3 | 0.719639 | 6 | 0 | 6 |
| TLR8 | NPY2R | 0.715531 | 3 | 0 | 3 |
| TLR8 | TNP1 | 0.706827 | 3 | 0 | 3 |
| TLR8 | CD1D | 0.705006 | 3 | 0 | 3 |
| TLR8 | ORM1 | 0.704033 | 3 | 0 | 3 |
| TLR8 | CD300LF | 0.701955 | 7 | 0 | 6 |
| TLR8 | SIGLEC10 | 0.700661 | 7 | 0 | 6 |
| TLR8 | ACTL6B | 0.697911 | 5 | 0 | 4 |
| TLR8 | CCR5 | 0.690863 | 4 | 0 | 4 |
| TLR8 | FMNL1 | 0.690261 | 5 | 0 | 5 |
| TLR8 | ZFHX2 | 0.688501 | 4 | 0 | 4 |
| TLR8 | FRMPD1 | 0.68223 | 3 | 0 | 3 |
| TLR8 | CNGB3 | 0.681035 | 3 | 0 | 3 |
| TLR8 | MAGEL2 | 0.680504 | 4 | 0 | 3 |
| TLR8 | SDHAF1 | 0.679098 | 3 | 0 | 3 |
For details and further investigation, click here
