| Full name: mevalonate kinase | Alias Symbol: LRBP|MK | ||
| Type: protein-coding gene | Cytoband: 12q24.11 | ||
| Entrez ID: 4598 | HGNC ID: HGNC:7530 | Ensembl Gene: ENSG00000110921 | OMIM ID: 251170 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MVK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MVK | 4598 | 36907_at | -0.1413 | 0.5750 | |
| GSE20347 | MVK | 4598 | 36907_at | -0.2021 | 0.0787 | |
| GSE23400 | MVK | 4598 | 36907_at | -0.1608 | 0.0000 | |
| GSE26886 | MVK | 4598 | 36907_at | -0.3618 | 0.0194 | |
| GSE29001 | MVK | 4598 | 36907_at | -0.3157 | 0.0326 | |
| GSE38129 | MVK | 4598 | 36907_at | -0.2568 | 0.0084 | |
| GSE45670 | MVK | 4598 | 36907_at | -0.0819 | 0.4019 | |
| GSE53622 | MVK | 4598 | 77141 | -0.3075 | 0.0000 | |
| GSE53624 | MVK | 4598 | 77141 | -0.3798 | 0.0000 | |
| GSE63941 | MVK | 4598 | 36907_at | 0.4091 | 0.0113 | |
| GSE77861 | MVK | 4598 | 36907_at | -0.2152 | 0.0199 | |
| GSE97050 | MVK | 4598 | A_23_P105592 | -0.2870 | 0.2564 | |
| SRP007169 | MVK | 4598 | RNAseq | -1.8514 | 0.0000 | |
| SRP008496 | MVK | 4598 | RNAseq | -2.2088 | 0.0000 | |
| SRP064894 | MVK | 4598 | RNAseq | -1.0344 | 0.0002 | |
| SRP133303 | MVK | 4598 | RNAseq | -0.7957 | 0.0032 | |
| SRP159526 | MVK | 4598 | RNAseq | -0.9187 | 0.0054 | |
| SRP193095 | MVK | 4598 | RNAseq | -0.8810 | 0.0000 | |
| SRP219564 | MVK | 4598 | RNAseq | -1.3500 | 0.0043 | |
| TCGA | MVK | 4598 | RNAseq | 0.0624 | 0.4487 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by MVK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MVK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MVK | 4598 | 5 | 3 | 22 | |
| GSE20123 | MVK | 4598 | 5 | 4 | 21 | |
| GSE43470 | MVK | 4598 | 2 | 1 | 40 | |
| GSE46452 | MVK | 4598 | 9 | 1 | 49 | |
| GSE47630 | MVK | 4598 | 9 | 1 | 30 | |
| GSE54993 | MVK | 4598 | 0 | 5 | 65 | |
| GSE54994 | MVK | 4598 | 4 | 3 | 46 | |
| GSE60625 | MVK | 4598 | 0 | 0 | 11 | |
| GSE74703 | MVK | 4598 | 2 | 0 | 34 | |
| GSE74704 | MVK | 4598 | 2 | 2 | 16 | |
| TCGA | MVK | 4598 | 22 | 10 | 64 |
Total number of gains: 60; Total number of losses: 30; Total Number of normals: 398.
Somatic mutations of MVK:
Generating mutation plots.
Highly correlated genes for MVK:
Showing top 20/1402 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MVK | FAXDC2 | 0.746249 | 9 | 0 | 9 |
| MVK | CACFD1 | 0.730948 | 7 | 0 | 7 |
| MVK | KIAA1614 | 0.729655 | 7 | 0 | 7 |
| MVK | IL9R | 0.726743 | 5 | 0 | 5 |
| MVK | ODF1 | 0.72369 | 5 | 0 | 5 |
| MVK | BFSP2 | 0.721443 | 5 | 0 | 5 |
| MVK | TCP10L | 0.715754 | 4 | 0 | 4 |
| MVK | MT4 | 0.715162 | 7 | 0 | 7 |
| MVK | GALR3 | 0.713488 | 11 | 0 | 10 |
| MVK | G6PC2 | 0.709453 | 7 | 0 | 6 |
| MVK | HTR4 | 0.699124 | 8 | 0 | 7 |
| MVK | VGLL2 | 0.69829 | 4 | 0 | 4 |
| MVK | GLYAT | 0.698195 | 8 | 0 | 8 |
| MVK | RNF17 | 0.695394 | 4 | 0 | 4 |
| MVK | RASSF7 | 0.69102 | 10 | 0 | 9 |
| MVK | LINC01210 | 0.690368 | 5 | 0 | 5 |
| MVK | LCN8 | 0.690191 | 5 | 0 | 5 |
| MVK | SEMA3B | 0.68942 | 6 | 0 | 5 |
| MVK | MMEL1 | 0.689013 | 4 | 0 | 3 |
| MVK | IL17RC | 0.686907 | 13 | 0 | 11 |
For details and further investigation, click here
