| Full name: opioid related nociceptin receptor 1 | Alias Symbol: NOCIR|ORL1|OOR|KOR-3|NOPr | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 4987 | HGNC ID: HGNC:8155 | Ensembl Gene: ENSG00000125510 | OMIM ID: 602548 |
| Drug and gene relationship at DGIdb | |||
Expression of OPRL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OPRL1 | 4987 | 206563_s_at | -0.1886 | 0.2665 | |
| GSE20347 | OPRL1 | 4987 | 206563_s_at | -0.1027 | 0.1513 | |
| GSE23400 | OPRL1 | 4987 | 206564_at | -0.1252 | 0.0082 | |
| GSE26886 | OPRL1 | 4987 | 206563_s_at | -0.0247 | 0.8535 | |
| GSE29001 | OPRL1 | 4987 | 206564_at | 0.0689 | 0.7064 | |
| GSE38129 | OPRL1 | 4987 | 206563_s_at | -0.1899 | 0.0071 | |
| GSE45670 | OPRL1 | 4987 | 206563_s_at | 0.0139 | 0.9230 | |
| GSE53622 | OPRL1 | 4987 | 25266 | 0.2257 | 0.1097 | |
| GSE53624 | OPRL1 | 4987 | 25266 | 0.1544 | 0.3880 | |
| GSE63941 | OPRL1 | 4987 | 206563_s_at | 0.0214 | 0.8679 | |
| GSE77861 | OPRL1 | 4987 | 206563_s_at | -0.1056 | 0.2295 | |
| GSE97050 | OPRL1 | 4987 | A_33_P3359647 | 0.2234 | 0.3269 | |
| SRP133303 | OPRL1 | 4987 | RNAseq | 0.1617 | 0.6389 | |
| SRP159526 | OPRL1 | 4987 | RNAseq | -0.0684 | 0.9016 | |
| SRP219564 | OPRL1 | 4987 | RNAseq | 0.7824 | 0.2013 | |
| TCGA | OPRL1 | 4987 | RNAseq | 0.1934 | 0.3602 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by OPRL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OPRL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OPRL1 | 4987 | 13 | 2 | 15 | |
| GSE20123 | OPRL1 | 4987 | 13 | 2 | 15 | |
| GSE43470 | OPRL1 | 4987 | 11 | 1 | 31 | |
| GSE46452 | OPRL1 | 4987 | 35 | 0 | 24 | |
| GSE47630 | OPRL1 | 4987 | 25 | 1 | 14 | |
| GSE54993 | OPRL1 | 4987 | 0 | 17 | 53 | |
| GSE54994 | OPRL1 | 4987 | 29 | 0 | 24 | |
| GSE60625 | OPRL1 | 4987 | 0 | 0 | 11 | |
| GSE74703 | OPRL1 | 4987 | 10 | 0 | 26 | |
| GSE74704 | OPRL1 | 4987 | 10 | 0 | 10 | |
| TCGA | OPRL1 | 4987 | 44 | 4 | 48 |
Total number of gains: 190; Total number of losses: 27; Total Number of normals: 271.
Somatic mutations of OPRL1:
Generating mutation plots.
Highly correlated genes for OPRL1:
Showing top 20/821 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OPRL1 | OR4F15 | 0.730613 | 3 | 0 | 3 |
| OPRL1 | DEFB108B | 0.712091 | 4 | 0 | 4 |
| OPRL1 | SYCN | 0.707331 | 3 | 0 | 3 |
| OPRL1 | CACNA1H | 0.703064 | 3 | 0 | 3 |
| OPRL1 | NGB | 0.701865 | 5 | 0 | 5 |
| OPRL1 | KRTAP5-7 | 0.700636 | 3 | 0 | 3 |
| OPRL1 | FAM222A-AS1 | 0.699037 | 3 | 0 | 3 |
| OPRL1 | FOXA3 | 0.698963 | 3 | 0 | 3 |
| OPRL1 | LINC00960 | 0.696656 | 3 | 0 | 3 |
| OPRL1 | CELA3A | 0.696271 | 6 | 0 | 4 |
| OPRL1 | CPA2 | 0.695764 | 3 | 0 | 3 |
| OPRL1 | SCNN1G | 0.692024 | 6 | 0 | 6 |
| OPRL1 | OR10H3 | 0.690882 | 4 | 0 | 4 |
| OPRL1 | GNRH2 | 0.687247 | 6 | 0 | 6 |
| OPRL1 | TNNI2 | 0.687111 | 3 | 0 | 3 |
| OPRL1 | RNF185-AS1 | 0.683679 | 4 | 0 | 4 |
| OPRL1 | MAGEC1 | 0.680402 | 4 | 0 | 4 |
| OPRL1 | PANX2 | 0.677366 | 3 | 0 | 3 |
| OPRL1 | IL18BP | 0.674226 | 5 | 0 | 5 |
| OPRL1 | WDR60 | 0.672414 | 3 | 0 | 3 |
For details and further investigation, click here
